Erythrocyte glutathione and serum glutathione-S-transferase in patients with brain tumors

Estimation of salivary protein thiols and total antioxidant power of saliva in brain tumor patients

“…Formation of brain tumors involves an accumulation of lesions in genes important for the regulation of cell proliferation, differentiation and death. [17][18][19] In our laboratory, various antioxidant levels have been assessed [2,4,5,20,21] previously and altered levels have been noticed. Altered levels of RBC glutathione and serum glutathione-S transferase [5] and significant reduction in the RBC glutathione reductase activity was observed in most type of brain tumor patients.…”

“…[17][18][19] In our laboratory, various antioxidant levels have been assessed [2,4,5,20,21] previously and altered levels have been noticed. Altered levels of RBC glutathione and serum glutathione-S transferase [5] and significant reduction in the RBC glutathione reductase activity was observed in most type of brain tumor patients. [2] Significantly elevated concentration of lipid peroxidation products had also been noticed in most type of intracranial neoplasms indicating increased susceptibility to free radical attack in these cases.…”

“…[1][2][3][4] Many different oxidative stress markers have been analyzed, both in serum and saliva of cancer patients. [5][6][7] Repeated analysis of these markers of oxidative stress may be needed at various stages viz. preoperative, post-operative and during the follow up, to establish the exact role of oxidative stress and antioxidants in these patients.…”

Susceptibility of peripheral lymphocytes of brain tumour patients to in vitro radiation-induced DNA damage, a preliminary study

“…Effect of radiation is mediated through the generation of free radicals [11] and the resultant damage is directly related to the antioxidant status of the cell. Earlier studies have shown that the level of key antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase and ceruloplasmin, and antioxidant molecules like glutathione are at a significantly lower level in brain tumour, oral leukoplakia and oral squamous cell carcinoma patients [8,[12][13][14][15].…”