2009
DOI: 10.1179/174313209x382296
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Plasma protein oxidation in patients with brain tumors

Abstract: Thus, free radical toxicity does lead to protein oxidation in patients with brain tumors.

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Cited by 7 publications
(7 citation statements)
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“…[20] Levels of protein thiols and protein carbonyls in serum of brain tumor patients have been studied as an indicator of protein damage due to oxidative stress and significant alterations in their levels were observed in these patients. [21] As an indicator of the burden of tumor growth (altered cellular antioxidant status, higher susceptibility of DNA to ROS), the in vitro susceptibility to radiation-induced DNA damage of peripheral lymphocytes had been studied in the brain tumor patients and significant results have been noticed. [22] Salivary flow rate has been observed to influence composition of saliva by affecting secretion and absorption in the ducts of the gland, including concentration of electrolytes, mucins etc, which in turn affect the osmolality and pH of saliva.…”
Section: Discussionmentioning
confidence: 99%
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“…[20] Levels of protein thiols and protein carbonyls in serum of brain tumor patients have been studied as an indicator of protein damage due to oxidative stress and significant alterations in their levels were observed in these patients. [21] As an indicator of the burden of tumor growth (altered cellular antioxidant status, higher susceptibility of DNA to ROS), the in vitro susceptibility to radiation-induced DNA damage of peripheral lymphocytes had been studied in the brain tumor patients and significant results have been noticed. [22] Salivary flow rate has been observed to influence composition of saliva by affecting secretion and absorption in the ducts of the gland, including concentration of electrolytes, mucins etc, which in turn affect the osmolality and pH of saliva.…”
Section: Discussionmentioning
confidence: 99%
“…Formation of brain tumors involves an accumulation of lesions in genes important for the regulation of cell proliferation, differentiation and death. [17][18][19] In our laboratory, various antioxidant levels have been assessed [2,4,5,20,21] previously and altered levels have been noticed. Altered levels of RBC glutathione and serum glutathione-S transferase [5] and significant reduction in the RBC glutathione reductase activity was observed in most type of brain tumor patients.…”
Section: Discussionmentioning
confidence: 99%
“…However, in contrast to the present study, bloods were collected on average 3 months after diagnosis and thus could have been impacted by disease. Previous smaller studies have provided conflicting evidence on the association between protein oxidation and cancer risk, with positive results for Hodgkin’s lymphoma9 and bladder cancer,10 but not for lung11 or brain12 cancer. None of these studies were prospective.…”
Section: Discussionmentioning
confidence: 99%
“…Here, our results reinforce this proposal since CPZ •+ oxidized easily the amino acids tryptophan, tyrosine and cysteine. As well established in the scientific literature, the oxidation of these amino acids has been implicated in the loss of functions of protein and has been detected in physiologically important proteins [17][18][19]. Here, special attention was given to tryptophan, since this amino acid was more reactive than tyrosine with CPZ •+ .…”
Section: Discussionmentioning
confidence: 99%