Erythrocyte Indices in Patients with Preeclampsia

Abstract

Objective: The purpose of study was to investigate erythrocyte indices in patients with preeclampsia. Materials and Methods:The study population consisted of 102 patients with preeclampsia (49 mild, 53 severe preeclampsia) and 98 control pregnant patients. For the entire study population, red blood cell indices, including baseline mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and red blood cell (RBC) were measured by using an automatic blood counter. Results: In the preeclampsia group, the median RDW was 15% (13.8-16.57), whereas in the control group it was 13.9% (13-15.6) (p<0.01). On the other hand, the mean MCV value was 80.42±7.86 (fL) in preeclampsia group and 83.88±2.31 (fL) in control group (p=0.003). Besides, the mean MCHC value was 33.66±1.71 (g/dL) in preeclampsia group and 33.09±1.48 (g/dL) in control group (p=0.012). However MCH and RBC values were not statistically different between the groups. (p>0.05) Moreover, subgroup analysis revealed that RDW levels were significantly increased in preeclampsia subjects than in mild preeclampsia patients (15.4% (13.9-17.45) vs 14.3% (13.7-15.7), p=0.031), MCV levels were decreased (78.81±7.91 (fL) vs 82.16± 7.43 (fL), p=0.03), RBC values were increased (4.16 (3.79-4.85)x(10 12 /L) vs 3.82 (3.45-4.34)x(10 12 /L), (p=0.006)) in patients with severe preeclampsia when compared to the patients with mild preeclampsia. In the receiver operator characteristic (ROC) analysis of subjects with and without preeclampsia, RDW and MCV showed high predictive values (p<0.01). Besides, in ROC analysis of preeclampsia patients with different severities, RDW and RBC showed the ideal predictive values (p=0.006, p=0.031, respectively). Conclusion: Our study results revealed that among the red blood cell indices, only increased RDW values were associated with both the presence and the severity of preeclampsia.Amaç: Bu çalışmanın amacı preeklampsi tanısı konmuş hastalarda eritrosit indekslerini araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 102 preeklampsi (49 hafif ve 53 şiddetli preeklampsi olmak üzere) ve 98 kontrol hastası dahil edilmiştir. Tüm çalışma grubunda eritrosit indeksleri olan ortalama korpuskular hacim (MCV), ortalama korpuskular hemoglobin (MCH), ortalama korpuskular hemoglobin konsantrasyonu (MCHC), eritrosit sayımı ve eritrosit dağılım genişliği değerleri otomatik kan sayım cihazı ile ölçüldü.Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

Neutrophil Lymphocyte Ratio and Red Cell Distribution Width as a Marker of Preeclampsia: A Retrospective Study

“…Increasing neutrophils are associated with increasing inflammation and on the other hand low levels of lymphocytes are associated with poor general health, increasing cortisol levels, and increasing level of apoptosis due to stressor [1,4,8]. Unfortunately, we did not find any significant difference of NTR between early and late onset of preeclampsia.…”

“…This was in accordance with other previous research. Several previous studies concluded that NTR has a prognostic value to predict diseases such as malignancy, coronary heart disease, and preeclampsia [1,4]. Oylumlu et al presented the increase levels of NTR in pregnancy with preeclampsia [5].…”

“…There are wide varieties of theories causing preeclampsia. The most unbreakable theory is the change of immunological system leading to increased inflammation response [1].…”

Red cell distribution width and preeclampsia: a systematic review and meta-analysis

“…All the 11 studies were of high quality with an Ottawa rating of 7 and 8 (Table 1). Of the eligible studies, 5 (45%) [15, 17, 18, 21, 23] and 2(18%) [22, 24] studies were conducted in Turkey and Sudan respectively. One (9%) study each was conducted in China, India, Taiwan and Indonesia.…”

“…The number of the cases per study ranged from 21 [35] to 143 [14], while the controls ranged from 50 [23] and 911 [14]. The median and variance was reported in three studies [18, 19, 21] and this was transformed to the mean (SD) using the prescribed formula [29, 30]. The mean (SD) of the RDW level was significantly higher in women with preeclampsia compared to controls [15.10 (2.48) % vs. 14.26(1.71) %, P < 0.001].…”