Erythrocyte membrane bioinspired near-infrared persistent luminescence nanocarriers for in vivo long-circulating bioimaging and drug delivery

Liu, Jingmin; Zhang, Dongdong; Fang, Guozhen; Wang, Shuo

doi:10.1016/j.biomaterials.2018.02.042

Cited by 92 publications

(83 citation statements)

References 42 publications

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“…The imaging window of near infrared enables a deeper tissue penetration, reducing the potential photocytotoxicity. For example, Liu et al reported the synthesis of core/shell ZGGO/MSNs coated with erythrocyte membrane for drug delivery in vivo [ 145 ]. Similarly, Wang et al have developed core/shell ZGGO@mesoporous silica shell (mSiO 2 ) nanoparticles with a tumour targeting biofilm coating, capable of targeted drug delivery, tracked by luminescent imaging in vivo [ 146 ].…”

Section: Optical Imagingmentioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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A biomedical contrast agent serves to enhance the visualisation of a specific (potentially targeted) physiological region. In recent years, mesoporous silica nanoparticles (MSNs) have developed as a flexible imaging platform of tuneable size/morphology, abundant surface chemistry, biocompatibility and otherwise useful physiochemical properties. This review discusses MSN structural types and synthetic strategies, as well as methods for surface functionalisation. Recent applications in biomedical imaging are then discussed, with a specific emphasis on magnetic resonance and optical modes together with utility in multimodal imaging.

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Section: Optical Imagingmentioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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“…In order to solve these issues, the development of imaging-induced precise therapies is of great signicance to overcome malignant tumour diseases. 86,87 VPLNPs can be excited by visible light, which avoids extra light damage caused by in vivo excitation and is one of the important uorescent probes for imaging-guided precise treatment. 88,89 Without background uorescence, VPLNPs has high signal-to-noise ratio, long luminous time, and have received widespread attention from scientists in recent years.…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%

“…Accurate drug delivery is one of the important strategies for accurate treatment. 86,87,[90][91][92] Through the imaging and tracking of drug carriers, medical staff can monitor the distribution of drugs can in real time and determine the plan of treatment for the next step. In 2015, Zhang et al developed multifunction VPLNPs for drug delivery and targeted tumour imaging.…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

Lin

et al. 2020

Nanoscale Adv.

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“…Concurrent with wide nano applications are increasing exposure risks of NMs to the human body. In addition to environmental exposure, NMs and their composite systems can directly contact tissue or a damaged wound, as they are inhaled, taken orally, or even injected directly into the biological system in a medical situation [6][7][8][9]. For these considerations, a large number of studies have investigated the biological hazard of NMs through varying exposure pathways [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Erythrocyte membrane bioinspired near-infrared persistent luminescence nanocarriers for in vivo long-circulating bioimaging and drug delivery

Cited by 92 publications

References 42 publications

Mesoporous Silica Nanoparticles in Bioimaging

Mesoporous Silica Nanoparticles in Bioimaging

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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