Erythrocyte membrane-camouflaged Prussian blue nanocomplexes for combinational therapy of triple-negative breast cancer

Chen, Simin; Fan, Jialong; Xiao, Feng; Yan, Qin; Long, Ying; Yuan, Liqin; Liu, Bin

doi:10.1039/d2tb02289c

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…The photothermal conversion efficiency of TPM@AM was 46.25%, according to Figures 1F and S12, which is higher than those of Indocyanine green (14.7%) 37 and Prussian blue nanocomplexes (44.9%). 38 In short, TPM@AM possessed remarkable photostability and photothermal conversion capability.…”

Section: Resultsmentioning

confidence: 99%

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Chen

Xie

et al. 2023

ACS Appl. Mater. Interfaces

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Ferroptosis, an iron-dependent cell death driven by the lethal levels of lipid peroxidation (LPO), becomes a promising anticancer strategy. However, the anticancer efficacy of ferroptosis is often hindered by the activation of nuclear factor erythrocyte 2-associated factor 2 (Nrf2), which is an indispensable regulator of the cellular antioxidant balance by preventing the accumulation of intracellular reactive oxygen species (ROS). Herein, we present a rational design of a Tf-targeted cascade nanoplatform TPM@AM based on mesoporous polydopamine (MPDA) co-encapsulating a ferroptosis inducer (artesunate, ART) and an Nrf2-specific inhibitor (ML385) to enhance intracellular ROS and therefore amplify ferrotherapy. Transferrin (Tf) can specifically recognize the transferrin receptor (TfR) on the surface of the cell membrane, which binds and transports iron into cells. When TPM@AM is endocytosed, the high-acid tumor microenvironment and laser irradiation trigger the collapse of MPDA to release ART and ML385. Furthermore, MPDA endows the nanoplatform with photothermal capability. The nanoplatform exhibits high efficiency for synergistic tumor suppression, representing a spatiotemporal controllable therapeutic strategy for precise synergistic cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Chen

Xie

et al. 2023

ACS Appl. Mater. Interfaces

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“…In recent years, biomimetic nanoparticles coatings with cell membranes have been extensively studied, and different sources of cell membranes have different nanoparticles delivery functions. − For example, cell membranes from tumor cells can encapsulate and deliver chemotherapeutic drugs to target and inhibit tumors . Erythrocyte-derived cell membranes functionalized nanoparticles have a high immune system escape function . In addition to this, immune cell membranes such as macrophage membranes-derived functionalized nanoparticles have a role in chemotactic targeting of inflammation .…”

Section: Introductionmentioning

confidence: 99%

“…29 Erythrocyte-derived cell membranes functionalized nanoparticles have a high immune system escape function. 30 In addition to this, immune cell membranes such as macrophage membranes-derived functionalized nanoparticles have a role in chemotactic targeting of inflammation. 31 Macrophage membranes selectively adhere and infiltrate into SCI lesions through the interaction of relevant receptors on the cell membrane with the endothelium of the damaged spinal cord microvasculature.…”

Section: Introductionmentioning

confidence: 99%

Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

An,

Jiang,

et al. 2023

ACS Appl. Nano Mater.

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Secondary injury following spinal cord injury (SCI) results in a large production of reactive oxygen species (ROS) (e.g., H 2 O 2 ) in the spinal cord microenvironment, which then leads to an excessive burst of inflammation and ultimately neuronal death. In this study, we prepared manganese dioxide (MnO 2 ) nanoparticles coated by macrophage membranes, named M@MnO 2 , to cope with early ROS bursts in the SCI microenvironment. The biosafety and targeting ability of the MnO 2 nanoparticles were improved through the macrophage membranes. Successful preparation of M@MnO 2 was verified by transmission electron microscopy, Western blot, and dynamic light scattering. Small animal imaging showed that M@MnO 2 accumulated in large quantities at the site of SCI. In the early stages of SCI, M@MnO 2 effectively reduced the ROS content, as well as the hypoxia-inducible factor 1α (HIF-1α) content, malondialdehyde content, and superoxide anion content caused by ROS, further leading to a decrease in some of the proteins associated with inflammation at the site of SCI (CD11b, CD86, COX2, IL-1β, and iNOS), ultimately achieving neuroprotection and recovery of motor function.

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Multifunctional Chi-Ag@HMPB@CBD nanocomposites for eradicating multidrug-resistant bacteria and promoting diabetic damaged tissue repair

Yin,

Wu,

Tong

et al. 2024

Chemical Engineering Journal

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Erythrocyte membrane-camouflaged Prussian blue nanocomplexes for combinational therapy of triple-negative breast cancer

Abstract: Although combined photodynamic/photothermal therapy (PDT/PTT) has been used for cancer theranostics recently, their therapeutic efficacy was often compromised by the low O2 partial pressure and high concentration of GSH in...

Cited by 7 publications

References 33 publications

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

Multifunctional Chi-Ag@HMPB@CBD nanocomposites for eradicating multidrug-resistant bacteria and promoting diabetic damaged tissue repair

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Erythrocyte membrane-camouflaged Prussian blue nanocomplexes for combinational therapy of triple-negative breast cancer

Abstract: Although combined photodynamic/photothermal therapy (PDT/PTT) has been used for cancer theranostics recently, their therapeutic efficacy was often compromised by the low O2 partial pressure and high concentration of GSH in...

Cited by 7 publications

References 33 publications

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Macrophage Membrane-Coated MnO2 Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

Multifunctional Chi-Ag@HMPB@CBD nanocomposites for eradicating multidrug-resistant bacteria and promoting diabetic damaged tissue repair

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Product

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Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury