Erythrocyte membrane fatty acids in multiple myeloma patients

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

“…[8,24,28–30] Indeed, there is a positive correlation between CRC risk and SFA levels. However, PUFA levels show a negative correlation with such cancers.…”

Docosahexaenoic acid attenuates in endocannabinoid synthesis in RAW 264.7 macrophages activated with benzo(a)pyrene and lipopolysaccharide

“…Furthermore, these acids act as ligands for nuclear peroxisome proliferator-activated receptors that attenuate transcription of NF-kB dependent genes (Calder, 2015;Fritsche, 2015;Jurczyszyn et al, 2014, Gdula-Argasi nska 2016.…”

Recent developments in fatty acids profile determination in biological samples - a review

“…With very few exceptions (8,16,18), the mobile phase used for the separation of FAME is helium. Likewise, the detector usually coupled with a GC system is a mass spectrometer detector, but there are studies which are using the flame ionization detector (1,(6)(7)(8)15,16,18,20). The MS detector is preferred due to its high selectivity towards the analyte and due to the possibility to precisely identify the analytes in a spectral mass database (NIST, Wiley etc.).…”

“…In the first case, authors (12,13,15) have separated FA from colorectal cancer tissue and healthy adjacent cells as control obtained postoperatively, and from erythrocyte membranes in multiple myeloma patients, after derivatization to FAME. Results showed, in all cases, an increase in the profile of some saturated fatty acids (SFA) and also a decrease in the profile of mono-unsaturated fatty acids (MUFA) in the cancerous tissue compared to the normal cells.…”

“…The methods described in the literature for the separation and/or quantification of fatty acids in different samples are mostly gas-chromatographic (1)(2)(3)(5)(6)(7)(8)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), among which most developed methods use a mass-spectrometer detector. However, liquid-chromatography (4,17,(23)(24)(25)(26)(27)(28)(29)(30)(31) has been presented by several authors and also, there are few articles which deal with other techniques such as capillary electrophoresis or infrared (IR) and Raman spectroscopy (16,31,32).…”