Erythrocyte morphological states, phases, transitions and trajectories

Rudenko, S. V.

doi:10.1016/j.bbamem.2010.05.010

Cited by 39 publications

(31 citation statements)

References 68 publications

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“…Phospholipids missing from the outer membrane bilayer of RBCs can cause expansion of the inner leaflet relative to the outer leaflet, resulting in membrane shape transformations. 50,67 Our observation of changed erythrocyte shape is partly consistent with the findings of Han et al, 35 ie, that the surface charge on NPs is the dominant factor influencing their hemocompatibility, but the findings of our study suggest that the sizes of NPs and their agglomerates also play an important role. In addition, Asharani et al 34 reported that the low degree of surface deposition of NPs on the membrane of RBCs can be accompanied by significant alterations in membrane topography.…”

Section: Mlvs After Incubation In Np Suspensionssupporting

confidence: 82%

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Drašler¹,

Drobne²,

Novak³

et al. 2014

IJN

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Background The purpose of this work is to provide experimental evidence on the interactions of suspended nanoparticles with artificial or biological membranes and to assess the possibility of suspended nanoparticles interacting with the lipid component of biological membranes. Methods 1-Palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine (POPC) lipid vesicles and human red blood cells were incubated in suspensions of magnetic bare cobalt ferrite (CoFe 2 O 4 ) or citric acid (CA)-adsorbed CoFe 2 O 4 nanoparticles dispersed in phosphate-buffered saline and glucose solution. The stability of POPC giant unilamellar vesicles after incubation in the tested nanoparticle suspensions was assessed by phase-contrast light microscopy and analyzed with computer-aided imaging. Structural changes in the POPC multilamellar vesicles were assessed by small angle X-ray scattering, and the shape transformation of red blood cells after incubation in tested suspensions of nanoparticles was observed using scanning electron microscopy and sedimentation, agglutination, and hemolysis assays. Results Artificial lipid membranes were disturbed more by CA-adsorbed CoFe 2 O 4 nanoparticle suspensions than by bare CoFe 2 O 4 nanoparticle suspensions. CA-adsorbed CoFe 2 O 4 -CA nanoparticles caused more significant shape transformation in red blood cells than bare CoFe 2 O 4 nanoparticles. Conclusion Consistent with their smaller sized agglomerates, CA-adsorbed CoFe 2 O 4 nanoparticles demonstrate more pronounced effects on artificial and biological membranes. Larger agglomerates of nanoparticles were confirmed to be reactive against lipid membranes and thus not acceptable for use with red blood cells. This finding is significant with respect to the efficient and safe application of nanoparticles as medicinal agents.

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Section: Mlvs After Incubation In Np Suspensionssupporting

confidence: 82%

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Drašler¹,

Drobne²,

Novak³

et al. 2014

IJN

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“…This may strongly support the low pHi, observed in RBCs tending to a stomatocytic transformation, and the caspase 3 activation always linked to an acidic pHi [20, 38], both conditions observed in the presence of CPZ. This caspase 3 is a zymogen maintained in an inactive structural conformation, by an Asp-Asp-Asp regulatory tripeptide named “safety-catch” [21].…”

Section: Discussionsupporting

confidence: 57%

“…But it appears quite surprising if it is evaluated that PB3 is highly expressed in the RBC membrane just where the drug is mostly concentrated. The action of CPZ on the membrane has been widely demonstrated by the observation of the induction of stomatocytic transformation, always linked to a decrease in cytoplasmic pH (pHi) [20, 38]. …”

Section: Discussionmentioning

confidence: 99%

Short‐Term Effects of Chlorpromazine on Oxidative Stress in Erythrocyte Functionality: Activation of Metabolism and Membrane Perturbation

Ficarra

Russo

Barreca

et al. 2016

Oxidative Medicine and Cellular Longevity

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The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic effects or complications due to chlorpromazine, but most of these studies explore the influence of long-term treatment. We think that evaluating the short-term effects of the drug may help to clarify the sequence of chlorpromazine molecular targets from which some long-term effects derive. Our results indicate that although the drug is primarily intercalated in the innermost side of the membrane, it does not influence band 3 anionic flux, lipid peroxidation, and protein carbonylation processes. On the other hand, it destabilizes and increases the autooxidation of haemoglobin, induces activation of caspase 3, and, markedly, influences the ATP and reduced glutathione levels, with subsequent exposure of phosphatidylserine at the erythrocyte surface. Overall our observations on the early stage of chlorpromazine influence on erythrocytes may contribute to better understanding of new and interesting characteristics of this compound improving knowledge of erythrocyte metabolism.

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“…We hypothesize that acute lowering of the ZP can result in an acute increase in endothelial cell permeability and acute alteration in RBC morphology from dispersed biconcave discs to adherent rouleaux formations [248], echinocyte, stomatocyte, acanthocyte, and spherocyte transformations [113,[293][294][295][296][297][298][299][300][301][302][303][304][305][306], with consequent elevation in blood viscosity, elevated resistance to microvascular blood flow, diminished oxygen transport, and diminished oxygen delivery. CO 2 overload is a secondary inevitable consequence of the acute colloidal instability of our blood induced by the ZP-lowering, polycationic surfactant stress.…”

Section: Discussionmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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Abstract:In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events that begins with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel hypothesis as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade.Keywords: inflammation; serum sickness; colloidal instability; interfacial water stress; bio-sulfates; Shwartzman phenomena; sudden death syndrome Glossary of TermsAnaphylaxis a severe, rapidly progressing, life-threatening, generalized allergic reaction. Biological equipoise a stable, non-equilibrium, dissipative system synonymous with life. Cholesterol sulfate (Ch-S)quantitatively the most important known sterol sulfate in human plasma where it regulates the activity of the serine proteases, in cell membranes where it has a stabilizing role, and in platelet membranes where it supports platelet adhesion. Coherence domain (CD)a water CD is a collection of liquid water molecules which oscillate in unison in tune with a self-trapped electromagnetic field at a well-defined frequency. The coherent oscillations produce an ensemble of quasi-free electrons, able to collect noise energy from the environment and transform it into high-grade coherent energy in the form of electron vortices. This high-grade energy may then activate biomolecules resonating with the water CD. Colloidal instabilitya property attributed to a colloidal suspension that develops when stabilizing repulsive steric and electrostatic forces between colliding particles are insufficient to prevent their natural tendency to aggregate into masses large enough to precipitate.Colloidal suspension a colloid that has a continuous liquid phase in which a solid is suspended in a liquid, e.g., our flowing blood. Exclusion zone (EZ)a glass-like, gel phase consisting of water CDs resonating in-phase, adjacent to hydrophilic surfaces, several hundred micrometers wide which excludes colloi...

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Erythrocyte morphological states, phases, transitions and trajectories

Cited by 39 publications

References 68 publications

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Short‐Term Effects of Chlorpromazine on Oxidative Stress in Erythrocyte Functionality: Activation of Metabolism and Membrane Perturbation

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

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