Erythrocyte sedimentation rate during steady state and painful crisis in sickle cell anemia

Lawrence, Christine; Fabry, Mary E.

doi:10.1016/0002-9343(86)90349-9

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…The decreased RBC deformability during VOC is in agreement with the hypothesis of Ballas and Smith (1992), suggesting that the most deformable sickled RBC are sequestrated within the microcirculation during VOC because of their maximal adhesiveness to the endothelium. The slightly but significantly higher RBC aggregation during VOC is consistent with a previous report showing increased erythrocyte sedimentation rate in SCA patients during VOC (Lawrence & Fabry, 1986). These RBC aggregates tended to be robust during VOC, which could slow down blood flow at capillary entry.…”

Section: New Insights Into Red Cell Rheology and Adhesion In Patientssupporting

confidence: 91%

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

et al. 2018

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Section: New Insights Into Red Cell Rheology and Adhesion In Patientssupporting

confidence: 91%

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

et al. 2018

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“…Several studies reported an increase in apparent plasma viscosity during VOC with peak values on or after day 6 [29,31,32]. The observation also suggests that the increase, at least in part, is secondary to the increase in plasma fibrinogen.…”

Section: Hemorheological Profile In Scd During Vaso-occlusive Crismentioning

confidence: 84%

“…No study to date measured the changes in RBC aggregation during a vaso-occlusive event in SCA and only limited data is available on erythrocyte sedimentation rate (ESR), a parameter that is affected by both Hct and RBC aggregation [29,30]. The increase of fibrinogen during VOC could promote RBC aggregation [30] but further studies are needed to directly investigate this parameter during crisis.…”

Section: Hemorheological Profile In Scd During Vaso-occlusive Crismentioning

confidence: 99%

The role of blood rheology in sickle cell disease

et al. 2016

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Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellular modulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives.

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“…The influence of the RBC shape on aggregation and sedimentation has not been studied systematically. It is known, however, that acanthocytes (Salt et al, 1960) or sickle cells (Janet al, 1981: Lawrence & Fabry, 1986) decrease the ESR.…”

mentioning

confidence: 99%

Red blood cell aggregation and sedimentation: the role of the cell shape

1989

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The influence of erythrocyte shape changes on the sedimentation rate was studied in vitro and in vivo. In vitro the highest sedimentation rate was observed with a slight degree of stomatocytosis (morphological index-0.3; i.e. one red cell out of three being a stomatocyte I). With increasing degrees of stomatocytosis the sedimentation rate gradually decreased. Echinocytosis reduced the aggregation and sedimentation very drastically; the sedimentation rate was virtually zero when echinocytosis I or higher degrees were present. The influence of abnormal cell shapes occurring in vivo was studied in patients with an abnormal blood smear. It was found that a severely abnormal red cell morphology reduced the sedimentation rate in a standardized, fibrinogen-rich plasma to about half. These results indicate that the shape plays a crucial role in the aggregation and sedimentation of red cells and they may contribute to the understanding of the interaction of red cells with other cells such as endothelium.

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Erythrocyte sedimentation rate during steady state and painful crisis in sickle cell anemia

Cited by 23 publications

References 23 publications

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

The role of blood rheology in sickle cell disease

Red blood cell aggregation and sedimentation: the role of the cell shape

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