Erythrocyte Sedimentation Rate in Glomerular Disease: Association with Urinary Protein

Liverman, P C; Tucker, F L; Bolton, W. Kline

doi:10.1159/000167618

Cited by 8 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings have already been shown in previous studies [1-7, 9-12, 15]. The results in the present study confirmed the finding of Liverman et al [15] who recently found a direct association of ESR with urine protein excretion in glomerular disease. With institution of ste roid therapy, FDP started to decrease, and platelet count, a2M, ATI II, Pig, a2AP and protein C started to increase despite unchanged nephrotic state from that before ste roid therapy, in remission induced by steroids, these changes were held except for ESR, fibrinogen and FDP which normalized during off-steroid therapy.…”

Section: Discussionsupporting

confidence: 94%

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Ueda¹

1990

Nephron

View full text Add to dashboard Cite

Effect of corticosteroids (steroids) on some hemostatic parameters was serially studied in 23 children with minimal change nephrotic syndrome (MCNS). Increased platelet count, erythrocyte sedimentation rate (ESR), cholesterol, fibrinogen, fibrin(ogen) degradation products (FDP), α2-macroglobulin (α2M), α2-antiplasmin (α2AP) and protein C, and reduced antithrombin III (ATIII) and plasminogen (Plg) were noted in relapse before steroid therapy began. With institution of oral prednisolone, FDP started to fall, and platelet count, cholesterol, α2M, ATIII, Plg, α2AP and protein C started to increase despite unchanged nephrotic state from that before the therapy. In remission induced by prednisolone, platelet count, cholesterol, α2M, ATIII, Plg, α2AP and protein C were still increased, but normalized off therapy. ESR, fibrinogen, FDP, α2M and protein C correlated inversely with serum albumin and directly with cholesterol and urine protein excretion. In contrast, ATIII and Plg correlated directly with serum albumin and inversely with cholesterol and urine protein excretion. A direct correlation was only noted between α2AP and the dose of prednisolone. The data indicate that steroids appear to be a thrombogenic factor by accerelating thrombocytosis and hyperlipidemia, and by reducing plasma fibrinolysis in children with MCNS.

show abstract

Section: Discussionsupporting

confidence: 94%

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Ueda¹

1990

Nephron

View full text Add to dashboard Cite

show abstract

“…The mechanism(s) possibly associated with the increased fibrinogen production in type 2 diabetes have been previously discussed in detail [20,21,35], and may include insulin resistance, hyperglucagonaemia, increased fibrinogen degradation products acting as stimulators of fibrinogen production in the liver, and possibly, also a subclinical inflammatory state otherwise not detectable by standard assays. In our albuminuric type 2 diabetes patients, the increased ESR, which is a common finding in albuminuria [36], may indicate the occurrence of a mild inflammatory state, despite the normality of other biochemical (leucocyte counts, urinalysis, α 2 -globulins) and clinical indices of inflammation, with the exception of a mild, albeit insignificant, increase of CRP. Therefore, in addition to the previously mentioned factors, a subclinical inflammatory condition, with the associated expected changes in inflammatory cytokines (that were not measured in this study), may represent a stimulus towards increased fibrinogen production.…”

Section: Discussionmentioning

confidence: 61%

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis: Hyperfibrinogenaemia and albuminuria are cardiovascular risk factors, often coexisting in diabetic and non-diabetic people. Albuminuria in turn is associated with a compensatory albumin overproduction in non-diabetic patients. It is not known whether the presence of albuminuria in patients with type 2 diabetes mellitus is associated with greater albumin and fibrinogen production rates than in normoalbuminuric patients. Subjects, materials, and methods: Using leucine isotope methods, we measured fractional and absolute synthesis rates (FSR, ASR) of albumin and fibrinogen in post-absorptive type 2 diabetic patients with either normal (n=11) or increased (n=10) urinary albumin excretion. Results: In albuminuric patients, albumin FSR (16.2± 1.5%/day) and ASR (20.5±1.9 g/day) were greater (p<0.02 and p<0.05, respectively) than in normoalbuminuric patients (FSR=11.5±1.1%/day; ASR=15.7±1.2 g/day). Fibrinogen FSR was similar between patients with normal and increased albumin excretion, but concentration, the circulating pool and ASR of fibrinogen were 40 to 50% greater (p<0.035) in patients with albuminuria. Albuminuria was positively correlated with albumin ASR, with fibrinogen concentration, the fibrinogen pool and ASR, whereas albumin synthesis was inversely correlated with calculated oncotic pressure. Conclusions/interpretation: Synthesis of albumin and fibrinogen is upregulated in type 2 diabetic patients with increased urinary albumin excretion. Albuminuria is associated with enhanced fibrinogen and albumin synthesis.

show abstract

“…In addition, tumor lysis syndrome can cause uric acid nephropathy as well as crystal arthropathy. Finally, end-stage renal disease and proteinuria cause an elevated erythrocyte sedimentation rate, which should not be suspected as active rheumatic disease or occult malignancy [37,38]. …”

Section: Renal and Rheumatic Manifestations Of Other Systemic Diseasesmentioning

confidence: 99%

Renal co-morbidity in patients with rheumatic diseases

Anders

Vielhauer

2011

Arthritis Res Ther

View full text Add to dashboard Cite

Renal co-morbidity is common in patients with rheumatic disease based on regular assessment of serum and urine parameters of renal function. When patients present with both arthritis and renal abnormalities the following questions have to be addressed. Is kidney disease a complication of rheumatic disease or its management, or are they both manifestations of a single systemic autoimmune disease? Is rheumatic disease a complication of kidney disease and its management? How do rheumatic disease and kidney disease affect each other even when they are unrelated? The present review provides an overview of how to address these questions in daily practice.

show abstract

Erythrocyte Sedimentation Rate in Glomerular Disease: Association with Urinary Protein

Cited by 8 publications

References 14 publications

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

Renal co-morbidity in patients with rheumatic diseases

Contact Info

Product

Resources

About