Erythrocyte sphingolipid species as biomarkers of Alzheimer's disease

Mill, Jericha; Patel, Vihar; Okonkwo, Ozioma C.; Raife, Thomas J.

doi:10.1016/j.jpha.2021.07.005

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…RBC-GEM was updated to include the various metabolic processes for sphingolipid metabolism, thereby representing the processes for erythrocyte metabolic reprogramming due to S1P[171]. Metabolomic studies of RBCs have highlighted consistent sphingolipid phenotypes of neurodegenerative diseases[172] and the role of elevated S1P in promoting sickle cell disease progression[173]. Because RBCs are the largest reservoir of S1P [174,175] and ceramide formation by sphingomyelinase contributes to eryptosis[176], understanding RBC sphingolipid metabolism is essential to elucidate the contribution of RBC-derived S1P in the pathogenesis of various diseases[177]…”

Section: Resultsmentioning

confidence: 99%

RBC-GEM: a Knowledge Base for Systems Biology of Human Red Blood Cell Metabolism

Haiman,

D’Alessandro,

Palsson

2024

Preprint

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Advancements with cost-effective, high-throughput omics technologies have had a transformative effect on both fundamental and translational research in the medical sciences. These advancements have facilitated a departure from the traditional view of human red blood cells (RBCs) as mere carriers of hemoglobin, devoid of significant biological complexity. Over the past decade, proteomic analyses have identified a growing number of different proteins present within RBCs, enabling systems biology analysis of their physiological functions. Here, we introduce RBC-GEM, the most extensive and meticulously curated metabolic reconstruction of a specific human cell type to-date. It was developed through meta-analysis of proteomic data from 28 studies published over the past two decades resulting in a RBC proteome composed of more than 4,600 distinct proteins. Through workflow-guided manual curation, we have compiled the metabolic reactions carried out by this proteome. RBC-GEM is hosted on a version-controlled GitHub repository, ensuring adherence to the standardized protocols for metabolic reconstruction quality control and data stewardship principles. This reconstruction of the RBC metabolic network is a knowledge base consisting of 718 genes encoding proteins acting on 1,590 unique metabolites through 2,554 biochemical reactions: a 700% size expansion over its predecessor. This reconstruction as an up-to-date curated knowledge base can be used for contextualization of data and for the construction of a computational whole-cell model of a human RBC.

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Section: Resultsmentioning

confidence: 99%

RBC-GEM: a Knowledge Base for Systems Biology of Human Red Blood Cell Metabolism

Haiman,

D’Alessandro,

Palsson

2024

Preprint

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“…Binding of amyloid-beta to erythrocytes has been reported, and fibrils supposedly containing amyloid-beta have been visualized on erythrocytes [38]. A metabolomics study of Alzheimer's disease patients and controls identified 750 metabolites of which 7 increased and 24 decreased in erythrocytes of Alzheimer's disease patients [39]. The increased metabolites included argininate, Erythrocytes as Messengers for Information and Energy Exchange between Cells DOI: http://dx.doi.org/10.5772/intechopen.108321 2-oxoarginine, and N-acetylarginine, all of which are known to form as a result of deficiency of the enzyme arginase.…”

Section: Erythrocytes Alzheimer's Disease and Other Types Of Dementiamentioning

confidence: 99%

Erythrocytes as Messengers for Information and Energy Exchange between Cells

Johansson¹,

Falk²

2023

The Erythrocyte - A Unique Cell

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Evolution has created a hierarchy of systems for information and energy using different cells according to messages generated from DNA, RNA, and other sources. Erythrocytes are formed in high speed at about 2 × 106/s to balance dying or not working erythrocytes to maintain optimal energy and information transfer. Important information is handled by nucleotides and distribution of metal ions and phosphates when starting synthesis process. Handling of these processes needs kinases known to be magnesium-dependent. Oxygen delivered by erythrocytes is used by other cells to synthesize ATP and to increase reaction capacity. Complex signals to bone marrow balance erythroblasts before developing into reticulocytes and erythrocytes. We discuss some aspects of erythrocyte communication with other cells of the body with special focus on magnesium and selenium in this process.

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“…Lipidomics, a subclass of metabolomics, studies lipid homeostasis and networks in biological systems on a large scale. It has several uses in clinical [ 3 ] and biomedical sciences [ 4 ], pharmaceutical analysis [ 5 ], and environmental science [ 6 ]. Lipidomics can be classified as either targeted or untargeted lipidomics.…”

Section: Introductionmentioning

confidence: 99%