Erythrocyte superoxide dismutase activity in patients with digest cancer: adjuvant diagnosis test

Puşcaş, I; Baican, M; Coltâu, Marcela; Puscas, Carmen; Domuţa, Gabriela

doi:10.1016/s0304-3835(99)00200-1

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…GSH occurred primarily in conjunction with foreign compounds or their metabolites for detoxification and transport from body in the cancerous stage, so that GSH concentration and its dependent enzymes were increased in group II rats. Puscas et al (1999) have suggested that rapidly growing tumor cells exhibit lower SOD and catalase activities, corroborating our present observations. The lower activities of antioxidant enzymes in group II rats may due to increased scavenging of free radicals and superoxides (Sun 1990).…”

Section: Discussionsupporting

confidence: 93%

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Manivasagam¹,

Subramanian²,

Ganapathy³

et al. 2005

J Appl Biomed

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In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidantantioxidant status of the living system. However, the exact mechanism remains to be elucidated.

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Section: Discussionsupporting

confidence: 93%

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Manivasagam¹,

Subramanian²,

Ganapathy³

et al. 2005

J Appl Biomed

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“…Many studies have demonstrated low antioxidant activity in the tumor cells of the injured organ (pulmonary, hepatic, pancreatic cells, gastric cancer, etc.) (28). Dietary kelp could inhibit mammary carcinogenesis by enhancing antioxidant enzyme activity and reducing lipid peroxides in livers of treated rats; therefore, the algal antioxidant mediated mechanism had been hypothesized as a contributing factor for anticancer activity (29).…”

Section: Resultsmentioning

confidence: 99%

Anticancer and Antioxidant Activities of the Peptide Fraction from Algae Protein Waste

Sheih

Fang

Wu³

et al. 2010

J. Agric. Food Chem.

197

118

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Algae protein waste is a byproduct during production of algae essence from Chlorella vulgaris. There is no known report on the anticancer peptides derived from the microalgae protein waste. In this paper, the peptide fraction isolated from pepsin hydrolysate of algae protein waste had strong dose-dependent antiproliferation and induced a post-G1 cell cycle arrest in AGS cells; however, no cytotoxicity was observed in WI-38 lung fibroblasts cells in vitro. The peptide fraction also revealed much better antioxidant activity toward peroxyl radicals and LDL than those of Trolox. Among these peptides, a potent antiproliferative, antioxidant, and NO-production-inhibiting hendecapeptide was isolated, and its amino acid sequence was VECYGPNRPQF. These results demonstrate that inexpensive algae protein waste could be a new alternative to produce anticancer peptides.

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“…Accumulating evidence suggests that active oxygen and free radicals attack key biological molecules, leading to many degenerative disease conditions. , Many studies have demonstrated low antioxidant activity in tumor cells of injured organs (e.g., pulmonary, hepatic, pancreatic, and gastric cancer cells). , In previous work, the authors found that loach peptide could enhance the endogenous cellular defense system (including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) enzymes to eliminate reactive oxygen species when mice had high levels of active oxygen and free radicals due to fatigue . Therefore, loach peptide can protect cells against reactive oxygen species by scavenging free radicals and, thus, it can be hypothesized that it may serve as a potential source of anticancer agents.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Antiproliferative Activities of Loach (Misgurnus anguillicaudatus) Peptides Prepared by Papain Digestion

You

Zhao

Liu

et al. 2011

J. Agric. Food Chem.

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Loach protein hydrolysates (LPH) prepared by papain digestion were fractionated into four fractions, LPH-I (MW > 10 kDa), LPH-II (MW = 5-10 kDa), LPH-III (MW = 3-5 kDa), LPH-IV (MW < 3 kDa), and the in vitro antioxidant and antiproliferative (anticancer) activities of all fractions were determined. LPH-IV showed the lowest IC(50) value (16.9 ± 0.21 mg/mL) for hydroxyl radical scavenging activity and the highest oxygen radical scavenging capacity (ORAC) value (reaching 215 ± 5.9 mM Trolox/100 g loach peptide when the concentration was 60 μg/mL). Compared with other fractions, LPH-IV also exhibited stronger antiproliferative activity for human liver (HepG2), breast (MCF-7), and colon (Caco-2) cancer cell lines in a dose-dependent manner. When the protein concentration was 40 mg/mL, the HepG2 and MCF-7 cell proliferation of LPH-IV reached 7 and 4%, respectively, with no significant difference from those of LPH (8 and 7%, p > 0.05), with significantly less growth than those of LPH-I, LPH-II, and LPH-III, respectively (p < 0.05). The Caco-2 colon cell proliferation of LPH-IV was 12.8- and 8.7-fold smaller than those of LPH-I and LPH-II, respectively (p < 0.05). All of the fractions had a greater ability to inhibit Caco-2 colon cancer cell proliferation than to inhibit HepG2 liver cancer and MCF-7 breast cancer cell proliferation. The ORAC values of most of the fractions correlated (R(2) > 0.86, p < 0.01) with the antiproliferative activity of the three cancer cell lines, suggesting that higher antioxidant activity leads to better antiproliferative activity. However, further mechanistic and human clinical studies of the anticancer activity of loach protein hydrolysate fractions are needed.

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Erythrocyte superoxide dismutase activity in patients with digest cancer: adjuvant diagnosis test

Cited by 8 publications

References 11 publications

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Anticancer and Antioxidant Activities of the Peptide Fraction from Algae Protein Waste

Antioxidant and Antiproliferative Activities of Loach (Misgurnus anguillicaudatus) Peptides Prepared by Papain Digestion

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