Erythroderma: A clinicopathological study of 47 cases from 2018 to 2020

Abstract

Erythroderma, or exfoliative dermatitis, is an inflammatory disorder characterized by erythema and scaling, affecting most of the skin surface. It may be a result of many different causes such as previous dermatoses (psoriasis, eczema, atopic dermatitis [AD], pityriasis rubra pilaris, and pemphigus foliaceous), drug reactions, malignancies (mycosis fungoides [MF], Sézary syndrome, adult T cell leukemia/lymphoma), infections, and idiopathic disorders. Regardless of the etiology, the clinical appearance of erythroderma is similar in all patients. The most prominent physical examination findings in almost all patients are diffuse erythema and scaling. In a 2-year period, 47 patients who were hospitalized and treated in our department were included in the study. We classified patients into seven subgroups: psoriasis, AD, drug-induced erythroderma, MF, pityriasis rubra pilaris, bullous pemphigoid, and polymorphous light eruption. All patients had a biopsy during the acute stage and diagnoses were histopathologically confirmed. Some patients had multiple biopsies for histopathological confirmation. In our study, the majority of the patients were men over the age of 54. The most common etiological cause of erythroderma is psoriasis. We aim to analyze clinical, laboratory, and histopathological findings of erythrodermic inpatients prospectively in Istanbul University-Cerrahpasa Cerrahpasa Medical Faculty between

Diagnostic Role of Direct Immunofluorescence Assay in Determining The Etiology of Erythroderma: Experience in a Tertiary Referral Hospital

“…The mean age of affect study subjects in our study was 54.6 ± 23 years (range: 3-86 years, median: 61 years). In a retrospective study of 49 erythrodermic patients, the average age was reported to be 50.7 ± 17.9 years which was in concordance with our findings [4]. As an acquired-adulthood disease, erythroderma may have various underlying etiologies or may be idiopathic in at least 25% of 6…”

“…Average age at the onset differs among various studies and reported to be 50.7 and 57 years in two recent reports respectively. 3,4 Even though skin involvement is the predominant clinical picture of the condition, life-threatening systemic complications such as tachycardia, electrolyte imbalance, edema and unstable body temperature may accompany [3].…”

“…Erythroderma generally arises from the exacerbation and generalization of a pre-existing skin diseases, even though new-onset cutaneous eruptions such as adverse cutaneous drug eruptions (ACDE), psoriasis, systemic allergic contact dermatitis (SACD), autoimmune bullous skin diseases (ABSD) such as bullous pemphigoid, pemphigus foliaceus may also be the cause [3,4]. Identification of the associated cutaneous disease is not always that easy and requires longitudinal evaluation of the patient to reveal the underlying cause and manage the complications.…”

Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

“…This is a serious and potentially life-threatening systemic inflammatory skin disease, which progresses rapidly and has a long treatment cycle with mortality rate of 10%-20%. [1][2][3] This study aims to retrospectively analyze hospitalized patients with acquired immunodeficiency syndrome (AIDS) suffering from drug-induced erythroderma from January 2013 to December 2020 in the First Affi liated Hospital of Zhejiang University School of Medicine.…”

Inpatient teledermatology improves diagnostic accuracy and management of erythroderma in hospitalized patients

“…1,2 Erythroderma, a disease characterized by erythema with or without scaling over > 90% of body surface area, is a condition with high morbidity and mortality, which requires timely diagnosis and treatment. 3 Our study evaluated the diagnostic concordance and teledermatology impact on erythroderma diagnosis, investigations and treatment between referring hospitalists and the inpatient teledermatology teams at University of Pittsburgh Medical Center (UPMC).…”