Erythropoiesis and Malaria, a Multifaceted Interplay

Dumarchey, Aurélie; Lavazec, Catherine; Verdier, Frédérique

doi:10.3390/ijms232112762

Cited by 6 publications

(6 citation statements)

References 142 publications

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“…Lipoperoxidation end-product 4-HNE is slowly and continuously shed, provoking the adduction with functionally important proteins in immune cells [ 222 , 223 , 224 ]. This process leads to immunosuppression [ 218 , 219 , 225 , 226 , 227 ] and dyserythropoiesis [ 228 , 229 ] in the host.…”

Section: Protein Ptms In Plasmodium Parasite Growt...mentioning

confidence: 99%

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Schwarzer,

Skorokhod

2024

IJMS

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Post-translational modifications (PTMs) are essential for regulating protein functions, influencing various fundamental processes in eukaryotes. These include, but are not limited to, cell signaling, protein trafficking, the epigenetic control of gene expression, and control of the cell cycle, as well as cell proliferation, differentiation, and interactions between cells. In this review, we discuss protein PTMs that play a key role in the malaria parasite biology and its pathogenesis. Phosphorylation, acetylation, methylation, lipidation and lipoxidation, glycosylation, ubiquitination and sumoylation, nitrosylation and glutathionylation, all of which occur in malarial parasites, are reviewed. We provide information regarding the biological significance of these modifications along all phases of the complex life cycle of Plasmodium spp. Importantly, not only the parasite, but also the host and vector protein PTMs are often crucial for parasite growth and development. In addition to metabolic regulations, protein PTMs can result in epitopes that are able to elicit both innate and adaptive immune responses of the host or vector. We discuss some existing and prospective results from antimalarial drug discovery trials that target various PTM-related processes in the parasite or host.

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Section: Protein Ptms In Plasmodium Parasite Growt...mentioning

confidence: 99%

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Schwarzer,

Skorokhod

2024

IJMS

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“…It is not yet known which exact parasite-specific molecules directly mediate gametocyte sequestration, although multiple candidates have been proposed and investigated ( 10 – 14 ). In addition, it has also been shown that alterations in membrane deformability of the host erythrocyte and infection of erythroblasts by gametocyte-committed trophozoites (rings) in the bone marrow can contribute to gametocyte sequestration ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates

Kengne-Ouafo,

Bah,

Kemp

et al. 2023

Microbiol Spectr

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Our overall understanding of the developmental biology of malaria parasites has been greatly enhanced by recent advances in transcriptomic analysis. However, most of these investigations rely on laboratory strains (LS) that were adapted into in vitro culture many years ago, and the transcriptomes of clinical isolates (CI) circulating in human populations have not been assessed. In this study, RNA-seq was used to compare the global transcriptome of mid-stage gametocytes derived from three short-term cultured CI, with gametocytes derived from the NF54 reference laboratory strain. The core transcriptome appeared to be consistent between CI- and LS-derived gametocyte preparations, but some important differences were also observed. A majority of gametocyte-specific genes (43/53) appear to have relatively higher expression in CI-derived gametocytes than in LS-derived gametocytes, but a K-means clustering analysis showed that genes involved in flagellum- and microtubule-based processes (movement/motility) were more abundant in both groups, albeit with some differences between them. In addition, gametocytes from one CI described as CI group II gametocytes (CI:GGII) showed gene expression variation in the form of reduced gametocyte-specific gene expression compared to the other two CI-derived gametocytes (CI gametocyte group I, CI:GGI), although the mixed developmental stages used in our study is a potential confounder, only partially mitigated by the inclusion of multiple replicates for each CI. Overall, our study suggests that there may be subtle differences in the gene expression profiles of mid-stage gametocytes from CI relative to the NF54 reference strain of Plasmodium falciparum . Thus, it is necessary to deploy gametocyte-producing clinical parasite isolates to fully understand the diversity of gene expression strategies that may occur during the sequestered development of parasite sexual stages. IMPORTANCE Maturing gametocytes of Plasmodium falciparum are known to sequester away from peripheral circulation into the bone marrow until they are mature. Blocking gametocyte sequestration can prevent malaria transmission from humans to mosquitoes, but most studies aim to understand gametocyte development utilizing long-term adapted laboratory lines instead of clinical isolates. This is a particular issue for our understanding of the sexual stages, which are known to decrease rapidly during adaptation to long-term culture, meaning that many LS are unable to produce transmissible gametocytes. Using RNA-seq, we investigated the global transcriptome of mid-stage gametocytes derived from three clinical isolates and a reference strain (NF54). This identified important differences in gene expression profiles between immature gametocytes of CI and the NF54 reference strain of P . falciparum , suggesting increased investment in gametocytogenesis in clinical isolates. Our transcriptomic data highlight the use of clinical isolates in studying the morphological, cellular features and molecular biology of gametocytes.

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“…Five teams presented novel findings contributing to our understanding of erythropoiesis [5][6][7][8][9]. Six teams critically evaluated our current knowledge and defined novel innovative questions for future research [7,[10][11][12][13][14].…”

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confidence: 99%

“…One of the strengths of this Special Issue is the broad range of topics covered. The articles in this Special Issue provide a comprehensive overview of the molecular mechanisms that regulate erythropoiesis [6,7,10,14], the red cell physiology [8,9], and the interaction between erythroblast and mature RBC with pathogens [9,10]. Different aspects of RBC diseases [10,12,13] and RBC-related diseases [5,11] are analyzed in this Special Issue.…”

mentioning

confidence: 99%

“…The articles in this Special Issue provide a comprehensive overview of the molecular mechanisms that regulate erythropoiesis [6,7,10,14], the red cell physiology [8,9], and the interaction between erythroblast and mature RBC with pathogens [9,10]. Different aspects of RBC diseases [10,12,13] and RBC-related diseases [5,11] are analyzed in this Special Issue. The growing evidence of the crucial interaction between RBC and cells from the red cell environment, such as macrophages [5,13] and endothelial cells [11], is noteworthy.…”

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confidence: 99%

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Physiology of Red Cell Lineage: From Erythroblast Progenitors to Mature Red Blood Cell

Ducamp

Ostuni

2023

IJMS

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Erythropoiesis and Malaria, a Multifaceted Interplay

Cited by 6 publications

References 142 publications

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates

Physiology of Red Cell Lineage: From Erythroblast Progenitors to Mature Red Blood Cell

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