Erythropoiesis in Hypothyroidism

Donati, Robert M.; Fletcher, John; Warnecke, M. A.; Gallagher, Neil I.

doi:10.3181/00379727-144-37531

Cited by 19 publications

(12 citation statements)

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“…These reports challenge the erythropoietin hypothesis because exogenous human erythropoietin alone failed to correct anemia in subclinical hypothyroid, chronic renal failure patients. Thus, it seems reasonable to conclude that thyroid hormones affect erythropoiesis in multiple ways including stimulating iron incorporation into erythrocytes (14) and increasing iron absorption (19) and by an inhibitory effect (15) or even by acting on its receptors to function as a switch between proliferation or differentiation of erythroid progenitors (20). There is no reason not to believe that these multiple mechanisms came into play in our study.…”

Section: Discussionmentioning

confidence: 70%

Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study

Cinemre

Bilir

Gökosmanoğlu

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 70%

Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study

Cinemre

Bilir

Gökosmanoğlu

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…It appears likely, however, that hypothyroidism per se, which is common in HT patients, impairs gastrointestinal iron absorption. Early experiments in hypothyroid rats showed diminished gastrointestinal iron absorption that was restored to normal on supplementation with T3 (86). In two studies in patients with coexisting iron-deficiency anemia and subclinical hypothyroidism, treatment with iron and T4 together was considerably more effective in improving iron status than treatment with iron alone (87,88).…”

Section: Hashimoto's Thyroiditis and Iron Deficiencymentioning

confidence: 99%

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

Rayman

2017

Thyroid

159

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“…In response to the diminished metabolism and the reduced requirements for oxygen, there is reduced erythropoietin production from the proximal renal tubules (11).…”

Section: Introductionmentioning

confidence: 99%

Effects of thyroid hormone replacement on glycated hemoglobin levels in non diabetic subjects with overt hypothyroidism

Anantarapu

Suresh

Sachan

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Glycated hemoglobin (HbA 1c ) may not accurately reflect the level of glycemia in conditions of altered erythrocyte turnover. Hypothyroidism is one condition associated with sluggish erythropoesis. To assess changes in HbA 1c , independent of changes in plasma glucose after initiation of thyroxine replacement in patients with overt hypothyroidism. Materials and methods: In this prospective longitudinal study carried out in a tertiary care centre, adult non-diabetic patients with overt hypothyroidism recruited between March 2012 to August 2013 were rendered euthyroid on thyroxine. They underwent testing for hemoglobin, HbA 1c , reticulocyte count, thyroxine, thyrotropin and a standard oral glucose tolerance test, both before and at 3 months after restoration to the euthyroid state. Main outcome assessed was the change in HbA 1c independent of the change in glucose parameters. Results: Thirty eight patients (35 female and 3 male) aged 37.8 ± 10.2 years with overt hypothyroidism (thyroxine 12.6 ± 13.4 ng/mL and thyrotropin -98.1 ± 63.7 µIU/mL respectively) were recruited. While HbA 1c fell from 5.8 ± 0.7% to 5.6 ± 0.5% (p = 0.009) at 3 months following the correction of hypothyroidism, there were no changes in the fasting and the 2 hr post oral glucose tolerance test glucose (p = 0.67 and 0.56 respectively). The number of patients with dysglycemia diagnosed by HbA 1c (i.e HbA 1c ≥ 5.7%) fell from 25 (65.78%) to 17 (44.7%) after treatment (p = 0.008). There were 7 (18.4%) patients with HbA 1c ≥ 6.5% at baseline, but this fell to just 4 (10.5%) (p < 0.001) after 3 months of euthyroidism. Conclusion: HbA 1c is not a reliable diagnostic test for diabetes in the presence of hypothyroidism. Arch Endocrinol Metab. 2015;59(6):495-500

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Erythropoiesis in Hypothyroidism

Cited by 19 publications

References 0 publications

Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study

Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

Effects of thyroid hormone replacement on glycated hemoglobin levels in non diabetic subjects with overt hypothyroidism

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