Objective. To characterize the factorial structure and psychometric properties of the Brazilian version of the Modified Reasons for Smoking Scale (MRSS). MethOds. The sample consisted of 311 smokers (214 male; mean age: 37.6 ± 10.8 years), who came to Hemocentro de Ribeirão Preto to donate blood. Volunteers answered 21 items of the Brazilian version of the MRSS, Fagerström test, and the Brazilian Criterion of Economic Classification. Scores of MRSS items were evaluated based on their grouping, employing exploratory factorial analysis. The influence of clinical features over the final factorial solution scores was also investigated. Results. Factorial analysis led to the characterization of seven factors: dependence, stimulation, pleasure to smoke, hand-mouth activity, social interaction, tension reduction/relaxation, and habit/ automatism. Four questions were excluded due to factorial loadings below 0.3. The final version was made up of 17 items showing a minimal factorial loading of 0.376. Women showed high scores in dependence (3.5 X 3.1), tension reduction/relaxation (4.1 X 3.5), and hand-mouth activity (2.4 X 2.0). Lower Fagerström test scores were associated to low scores in dependence, tension reduction/ relaxation, habit/automatism and stimulation. cOnclusiOn: The Brazilian version of the MRSS, comprised of 17 items, showed satisfactory factorial structure and psychometric properties.