Escherichia coli necrotizing fasciitis in Hirschsprung's disease

Alsaif, Manal; Robinson, Joan

doi:10.1016/j.epsc.2015.03.002

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is usually caused by Streptococcus pyogenes ( 8 , 9 ), sometimes Staphylococcus aureus ( 10 ) or by a mixture of microorganisms including Streptococcus , S. aureus , Enterobacteriaceae , and some anaerobes ( 11 , 12 ). On rare occasions, necrotoxigenic E. coli was identified as the etiologic agent in chronically ill patients ( 13 – 20 ) or infants following surgery ( 21 , 22 ). Recently, we reported a lethal case of very rapidly evolving necrotizing fasciitis.…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of a Necrotoxigenic Escherichia coli Isolate

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of a Necrotoxigenic Escherichia coli Isolate

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Chen et al [ 22 ] showed that E. coli was found in 2 out of 126 (1.6%) patients with necrotizing fasciitis caused by a single etiologic agent. Necrotizing fasciitis caused by E. coli has been reported from chronically ill patients [ 23 , 24 ] or infants following surgery [ 25 , 26 ] but with no mention of the virulence factors present. In a study of 102 E. coli strains isolated from skin and soft tissue infections, Petkovšek et al [ 27 ] showed that the toxin genes cnf1 and hlyA were present in 32 and 30% of the isolates, respectively, and that only 4% of the strains harbored eight or more virulence factors.…”

Section: Discussionmentioning

confidence: 99%

A Fatal Case of Necrotizing Fasciitis Caused by a Highly VirulentEscherichia coliStrain

Békal

Vincent

Harel

et al. 2016

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Necrotizing fasciitis is a serious disease characterized by the necrosis of the subcutaneous tissues and fascia. E. coli as the etiologic agent of necrotizing fasciitis is a rare occurrence. A 66-year-old woman underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. She rapidly developed necrotizing fasciitis which led to her death 68 hours following surgery. An E. coli strain was isolated from blood and fascia cultures. DNA microarray revealed the presence of 20 virulence genes.

show abstract

A systematic review of necrotising fasciitis in children from its first description in 1930 to 2018

Schröder¹,

Gerin

Firth

et al. 2019

BMC Infect Dis

View full text Add to dashboard Cite

Background Necrotising fasciitis is a rapidly progressing soft-tissue infection with a low incidence that carries a relevant risk of morbidity and mortality. Although necrotising fasciitis is often fatal in adults, its case fatality rate seems to be lower in children. A highly variable clinical presentation makes the diagnosis challenging, which often results in misdiagnosis and time-delay to therapy. Methods We conducted a protocol-based systematic review to identify specific features of necrotising fasciitis in children aged one month to 17 years. We searched ’PubMed’, ’Web of Science’ and ’SCOPUS’ for relevant literature. Primary outcomes were incidence and case fatality rates in population-based studies, and skin symptoms on presentation. We also assessed signs of systemic illness, causative organisms, predisposing factors, and reconstructive procedures as secondary outcomes. Results We included five studies reporting incidence and case fatality rates, two case-control studies, and 298 cases from 195 reports. Incidence rates varied between 0.022 and 0.843 per 100,000 children per year with a case-fatality rate ranging from 0% to 14.3%. The most frequent skin symptoms were erythema (58.7%; 175/298) and swelling (48%; 143/298), whereas all other symptoms occurred in less than 50% of cases. The majority of cases had fever (76.7%; 188/245), but other signs of systemic illness were present in less than half of the cohort. Group-A streptococci accounted for 44.8% (132/298) followed by Gram-negative rods in 29.8% (88/295), while polymicrobial infections occurred in 17.3% (51/295). Extremities were affected in 45.6% (136/298), of which 73.5% (100/136) occurred in the lower extremities. Skin grafts were necessary in 51.6% (84/162) of the pooled cases, while flaps were seldom used (10.5%; 17/162). The vast majority of included reports originate from developed countries. Conclusions Clinical suspicion remains the key to diagnose necrotising fasciitis. A combination of swelling, pain, erythema, and a systemic inflammatory response syndrome might indicate necrotising fasciitis. Incidence and case-fatality rates in children are much smaller than in adults, although there seems to be a relevant risk of morbidity indicated by the high percentage of skin grafts. Systematic multi-institutional research efforts are necessary to improve early diagnosis on necrotising fasciits. Electronic supplementary material The online version of this article (10.1186/s12879-019-3941-3) contains supplementary material, which is available to authorized users.

show abstract

Escherichia coli necrotizing fasciitis in Hirschsprung's disease

Cited by 3 publications

References 8 publications

Draft Genome Sequence of a Necrotoxigenic Escherichia coli Isolate

Draft Genome Sequence of a Necrotoxigenic Escherichia coli Isolate

A Fatal Case of Necrotizing Fasciitis Caused by a Highly VirulentEscherichia coliStrain

A systematic review of necrotising fasciitis in children from its first description in 1930 to 2018

Contact Info

Product

Resources

About