Escin induces apoptosis in ovarian cancer cell line by triggering S-phase cell cycle arrest and p38 MAPK/ERK pathway inhibition

Zhao, Wei; Lao, Yongxia; Niu, Jiqin; Xiao, Zhihui; Arulselvan, Palanisamy; Shen, Jian

doi:10.1016/j.jksus.2021.101644

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…Escin, a combination of triterpene and saponins derived from the Aesculus hippocastanum , has anti-tumor ability via autophagy and apoptosis regulation via ROS/p38 MAPK signaling [ 94 ].…”

Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.

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“…Escin, a combination of triterpene and saponins derived from the Aesculus hippocastanum , has anti-tumor ability via autophagy and apoptosis regulation via ROS/p38 MAPK signaling [ 94 ].…”

Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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“…A significant decrease in the viability of A2780 cells was also observed after the treatment with escin. However, it did not cause cytotoxicity to the normal Vero cells (immortalized cell line established from the kidney epithelial cells of the African green monkey) [ 58 ]. Recent studies confirm the anti-inflammatory properties of escin in decreasing the permeability of blood vessels in inflammation, which leads to the inhibition of edema formation.…”

Section: Discussionmentioning

confidence: 99%

“…A drastic increase in ROS generation, and apoptotic cells, following the saponin treatment was also observed. Escin suppressed the p38 MAPK/ERK signaling axis in A2780 cells [ 58 ]. Diosmin induced significant ROS generation in tumor cells: human breast cancer cells MCF-7, MDA-MB-231, and SK-BR-3 treated with diosmin [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Diosmin, Escin, and Bromelain on Human Endothelial Cells Derived from the Umbilical Vein and the Varicose Vein—A Preliminary Study

Gwoździński

Bernasińska-Słomczewska

Hikisz

et al. 2023

Biomedicines

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In this study, we investigated the properties of human varicose vein (VV) endothelial cells (HVVEC) in comparison to the human umbilical vein endothelial cells (HUVEC). The cells were treated with three bioactive compounds with proven beneficial effects in the therapy of patients with VV, diosmin, escin, and bromelain. Two concentrations of tested drugs were used (1, 10 mg/mL), which did not affect the viability of either cell type. Escin led to a slight generation of reactive oxygen species in HUVEC cells. We observed a slight release of superoxide in HVVEC cells upon treatment with diosmin and escin. Diosmin and bromelain showed a tendency to release nitric oxide in HUVEC. Using membrane fluorescent probes, we demonstrated a reduced fluidity of HVVEC, which may lead to their increased adhesion, and, consequently, a much more frequent occurrence of venous thrombosis. For the first time, we show the mechanism of action of drugs used in VV therapy on endothelial cells derived from a VV. Studies with HVVEC have shown that tested drugs may lead to a reduction in the adhesive properties of these cells, and thus to a lower risk of thrombosis.

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Sonoextraction of phenolic compounds and saponins from Aesculus hippocastanum seed kernels: Modeling and optimization

Días

Albiston²,

Añibarro-Ortega³

et al. 2022

Industrial Crops and Products

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Escin induces apoptosis in ovarian cancer cell line by triggering S-phase cell cycle arrest and p38 MAPK/ERK pathway inhibition

Cited by 7 publications

References 41 publications

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

The Effect of Diosmin, Escin, and Bromelain on Human Endothelial Cells Derived from the Umbilical Vein and the Varicose Vein—A Preliminary Study

Sonoextraction of phenolic compounds and saponins from Aesculus hippocastanum seed kernels: Modeling and optimization

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