Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway

Niu, Xiaofeng; Wang, Yu; Liu, Weifeng; Zhang, Hailin; Wang, Xiumei; Mu, Qingli; He, Zehong; Yao, Huan

doi:10.1016/j.intimp.2015.08.041

Cited by 66 publications

(37 citation statements)

References 35 publications

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“…In the present study, esculin ameliorated the inflammatory reaction in experimental DN mice. Niu et al (17) indicated that esculin exhibited potent anti-inflammatory activities in lipopolysaccharide-stimulated mice via regulation of TNF-α and IL-6 production, and the MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, MAPK signaling may be involved in the effect of esculin on diabetes. Additionally, Niu et al (17) indicated that esculin exhibited potent anti-inflammatory effects in LPS-stimulated mice through regulation of TNF-α and IL-6 production, and the MAPK pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Esculin is a derivative of coumarin, which is also an active ingredient of ash bark, and has antibacterial, anti-inflammatory, anti-allergy and skin protective effects (16,17). In addition, esculin was reported to treat increased capillary fragility and prevent peripheral vascular diseases (18).…”

Section: Introductionmentioning

confidence: 99%

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Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway

et al. 2018

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Esculin is a derivative of coumarin, which is also an active ingredient of ash bark, and has antibacterial, anti-inflammatory, anti‑allergy and skin protective effects. The underlying mechanism and protective effects of esculin on cognitive impairment in experimental diabetic nephropathy (DN) was investigated in the present study. Male C57BL/6J 6‑week‑old mice were injected intravenously with a single dose of streptozotocin (STZ; 30 mg/kg). At 2 weeks after the STZ injection, mice received intravenous injection with 5, 10 or 20 mg/kg esculin for 2 weeks. In the present study, the results of the Morris water maze test demonstrated that esculin significantly improved behavior and recognition memory in STZ‑induced diabetic rats. Furthermore, treatment of STZ‑induced diabetic rats with esculin significantly inhibited tumor necrosis factor‑α, interleukin‑6, malondialdehyde, monocyte chemoattractant protein‑1 and intracellular adhesion molecule‑1 activity levels, and increased the activity of superoxide dismutase, in the kidney, which was determined by ELISA. In addition, esculin treatment significantly suppressed the renal protein expression of activator protein 1, phosphorylated (p)‑p38 mitogen activated protein kinase (MAPK) and p‑c‑Jun N‑terminal kinase, and increased p‑extracellular signal regulated kinase 1/2 protein expression, in STZ‑induced diabetic rats, as determined by western blotting. These results indicate that esculin may ameliorate cognitive impairment in experimental DN, and exert anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway. Thus, it may serve as a potential target for cognitive impairment of DN in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway

et al. 2018

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“…52 Esculin has been reported that could reduce high expression of TNF-α and inhibit MMP9 expression. [53][54] Not only esculin but also gingerol, baicalein, and wogonin, another active compound interacted with baicelein, have interaction with MMP9 and TNF-α and moreover, some studies have been approved these compounds' effect toward MMP9 and TNF-α. [55][56][57] In tuberculosis treatment, it may be suggested that esculin, gingerol, wogonin, and baicelin reduce the level of TNF-α and MMP9.…”

Section: Plants Used For Treating Tuberculosis In Indonesia Provincesmentioning

confidence: 99%

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Aristyani¹,

Widyarti²,

Sumitro³

2018

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Background: Indonesia is the biggest archipelago country with the second biggest biodiversity in the world. A lot of medical plants for treating various diseases can be found in Indonesia, including medical plants for tuberculosis, an infectious disease caused by Mycobacterium tuberculosis. Objective: The goal of this research is to document the information of Indonesia indigenous medical plants that used various local societies to treat tuberculosis and also analyze active compounds of medical plants with proteins that related to tuberculosis. Methods and Materials: The annotation of medical plants for treating tuberculosis was collected from a various source comprising local research papers, theses, and other resources. The information of active compound was taken from Dr. Duke's Phytochemical and Ethnobotanical Databases. A network of active compounds-proteins was analyzed by using Cytoscape 3.6.0. Results: The result described that there were twenty-seven species from nineteen families of medical plants used by local societies of Indonesia for tuberculosis therapy, and there were sundry of active compounds from fourteen medical plants had direct interaction with proteins related tuberculosis. Conclusion: Most of the active compounds targeted proteins that had a prominent role in immune system. It indicated that medical plants treating tuberculosis through regulating immunity of human body. ABSTRACT SUMMARY • Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis. For a long time, Indonesia local societies have been used medical plants for tuberculosis therapy. By using network analysis study, the active compounds of medical plants can modulate human immunity to treat tuberculosis. Sherry Aristyani, a master student of Biology in Faculty of Mathematics and Natural Sciences, University of Brawijaya. Her master research focuses on active compounds of Indonesia medical plants for tuberculosis therapy. Sri Widyarti, Lecturer and researcher in Faculty of Mathematics and Natural Sciences, University of Brawijaya. She has expertise in biology cell. Sutiman Bambang Sumitro, a professor in Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya. He has expertise in biology cell, bioinorganic, and nano-biology. ABOUT AUTHORS

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“…chekiangensis (Hu et Fang) Fang, Aesculus chinensis Bge and Aesculus wilsonii Rehd are commonly used to treat chest and abdomen pain, dysentery and ague [1,2] in traditional Chinese medicine. Previous studies on the genus of Aesculus revealed the presences of diverse secondary metabolites such as triterpenoids [3][4][5][6][7], flavonoids [8,9], coumarins [10] and steroids [11]. And a number of pharmacological studies have suggested that A. chinensis exhibited beneficial effects on antitumor [12], neuroprotective [13], anti-inflammatory [14] and cardio-protective activities [15].…”

Section: Introductionmentioning

confidence: 99%

Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

et al. 2020

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Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl 2 -induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity.

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Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway

Cited by 66 publications

References 35 publications

Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway

Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

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