Esomeprazole as a prophylactic agent for acid aspiration syndrome in adult patients undergoing elective surgery: A triple blind placebo controlled clinical trial

Hussein, Abeer; Al-Saeed, AH; Habib, S Shahid

doi:10.1080/22201173.2008.10872567

Cited by 2 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Esomeprazole 20 mg given orally night prior to surgery raised the gastric pH to 4.75 in a study conducted by Hussein A et al, the mean value of pH being less than the current study which could be related with smaller dose 10 . Hussein A et al excluded the cases in case of aspiration mixed with bile to rule out possible bile contamination altering the gastric pH.…”

Section: Resultsmentioning

confidence: 88%

“…All the patients enrolled in the study were randomly assigned by lottery method to three groups with 50 patients in each. Group sizes of 50 were determined by the power study based on standard deviation data from previously published reports 9,10 . An 18 F orogastric tube was passed down to the stomach and its position was verifi ed by auscultation over the epigastrium with insuffl ations of 10 ml of air.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Gastric pH in patients premedicated with Esomeprazole or Famotidine undergoing routine surgery under general anaesthesia

Shrestha

Moktan

et al. 2013

J. Kathmandu Med. Coll.

View full text Add to dashboard Cite

Background: Stress and anxiety in patients planned for surgery under anaesthesia may change pH of gastric secretion. Premedication of surgical patients with pH altering drugs may modify the pH favourably. With the advent of newer agents, premedication has been carried out with different agents. Most of the time choice of drug is made by the perioperative physician on his/her own. Objective: To study gastric pH in patients premedicated either with Esomeprazole or Famotidine. Methods: This is a randomized controlled double blind prospective study conducted in 150 patients of American Society of Anesthesiologists grade I and II posted for elective surgery under general anaesthesia. The patients enrolled in the study were randomly assigned to three groups having 50 patients in each. Group I (control group) did not receive any pH altering drug, Group II (Famotidine Group) received 40 mg of Famotidine and Group III (Esomeprazole Group) received 40 mg of Esomeprazole the night before surgery. The observer was totally blind about the groups or drugs given to the patients. On the day of surgery, after induction of anaesthesia gastric juice was obtained via nasogastric tube and was checked for pH using pH indicator paper. Results: The pH raised by Esomeprazole was statistically signifi cant (p<0.001) when compared to that of control group or Famotidine group. The mean pH value in control group was less than 2.5 whereas the pH value was higher than 2.5 in patients premedicated with either Famotidine or Esomeprazole. Conclusions: Gastric pH is raised by Famotidine or Esomeprazole premedication prior to routine surgery, Esomeprazole being superior to Famotidine, p<0.001. Patients (84%) not premedicated with either of the drugs had pH less than 2.5.

show abstract

Section: Resultsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Gastric pH in patients premedicated with Esomeprazole or Famotidine undergoing routine surgery under general anaesthesia

Shrestha

Moktan

et al. 2013

J. Kathmandu Med. Coll.

View full text Add to dashboard Cite

show abstract

“…23 , K. Nishina et al (1999). 24 A Hussein et al (2008). 19 all have observed proton pump inhibitors significantly increases gastric pH as compared to control Group.…”

Section: Age In Yearsmentioning

confidence: 99%

“…18 A Hussein et al (2008). 19 and S Sadawarte et al (2009). 20 In the present study, gastric pH was estimated with portable pH meter after aspiration of gastric contents.…”

Section: Age In Yearsmentioning

confidence: 99%

Effects of Proton Pump Inhibitors on Gastric Volume and Gastric Ph in Adult Patients Posted for Elective Operative Procedures

Ahmed¹,

Patil²,

Deshpande³

et al. 2016

jemds

View full text Add to dashboard Cite

Under general anaesthesia even in elective operative procedure, there are chances of aspiration of gastric contents resulting in acid aspiration syndrome. H2 antagonists Ranitidine and Proton Pump Inhibitors were evaluated to compare efficacy of the drugs in decreasing gastric volume and increasing gastric pH when administered orally overnight and early in the morning; 250 patients of ASA grade I and II of either sex were divided in 5 equal Groups of 50 patients each. Group I patients received Tab. Placebo, Group II received Tab. Ranitidine 150 mg, Group III received Tab. Omeprazole 20 mg, Group IV received Tab. Pantoprazole 40 mg and

show abstract

Esomeprazole as a prophylactic agent for acid aspiration syndrome in adult patients undergoing elective surgery: A triple blind placebo controlled clinical trial

Cited by 2 publications

References 6 publications

Gastric pH in patients premedicated with Esomeprazole or Famotidine undergoing routine surgery under general anaesthesia

Gastric pH in patients premedicated with Esomeprazole or Famotidine undergoing routine surgery under general anaesthesia

Effects of Proton Pump Inhibitors on Gastric Volume and Gastric Ph in Adult Patients Posted for Elective Operative Procedures

Contact Info

Product

Resources

About