Esophageal cancer in high-risk areas of China: research progress and challenges

Lin, Yingsong; Totsuka, Yukari; Shan, Baoen; Wang, Chaocheng; Wei, Wenqiang; Qiao, You‐Lin; Kikuchi, Shogo; Inoue, Manami; Tanaka, Hideo; He, Yutong

doi:10.1016/j.annepidem.2016.11.004

Cited by 166 publications

(128 citation statements)

References 36 publications

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“…Esophageal squamous cell carcinoma (ESCC) is a major histological subtype among all types of the esophageal tumors, especially in China [2]. Limitations of the traditional chemotherapeutic treatment and an advanced stage at the time of diagnosis account for the worse prognosis of patients with ESCC [3–5].…”

Section: Introductionmentioning

confidence: 99%

Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells

Zhang

Shang

et al. 2017

Oncotarget

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Recent reports showed that regulator of Cullins-1 (ROC1) play an important role in tumor progression in a tumor-specific manner. However, the role and mechanism of ROC1 in esophageal cancer remains elusive. Here we demonstrated that ROC1 was overexpressed in esophageal squamous cell carcinomas, which was positive associated with poor prognosis of esophageal cancer patients. ROC1 knockdown significantly inhibited the growth of esophageal cancer cells in vitro and in vivo. Mechanistically, ROC1 silencing induced G2 cell cycle arrest and triggered apoptosis by accumulating the pro-apoptotic protein NOXA. Consistently, the downregulation of NOXA expression via siRNA substantially attenuated apoptosis induced by ROC1 silencing. These findings suggest that ROC1 is an appealing drug target for esophageal cancer.

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Section: Introductionmentioning

confidence: 99%

Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells

Zhang

Shang

et al. 2017

Oncotarget

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“…The benefits of early diagnosis and treatment of EC were demonstrated in a 10-year cohort study that reduced cumulative mortality (from 3.35% to 5.05%). 53 However, the necessity of the screening program cannot be validated without considering socioeconomic costs. The economic evaluation can be shown by its incremental cost-effectiveness ratio (ICER).…”

Section: Evaluation Of Cost-effectivenessmentioning

confidence: 99%

A suggested framework for conducting esophageal cancer screening in China

et al. 2018

J of Digest Diseases

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Esophageal cancer is one of the most prevalent malignant tumors worldwide. Because of its challenging clinical characteristics, esophageal cancer is a major disease burden on the economy, society, and individuals. There is an urgent need to establish a beneficial policy to reduce the burden and to improve the health‐related quality of life of patients. Primary prevention with smoking cessation and reduction of drinking alcohol are highly recommended. Screening, early diagnosis and treatment are suggested. This study intended to establish a modified future screening model from the social perspective that deploys different strategies for different populations. Risk assessment and community‐based screening are proposed for high‐risk populations. Health education in low‐risk areas could help promote primary prevention to mitigate lifestyle factors and to increase public awareness and potentially to increase screening and early detection.

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“…Among the leading causes of death, EC ranks fourth, with an average annual incidence of 17/1 000 000 . The exact cause of EC is not clear, but it is closely related to carcinogenicity, chemical stimulation, inflammation, and trauma, as well as genetics and life habits …”

Section: Introductionmentioning

confidence: 99%

PSMD4 regulates the malignancy of esophageal cancer cells by suppressing endoplasmic reticulum stress

Zhao

et al. 2019

The Kaohsiung J of Med Scie

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Proteasome 26S subunit non‐ATPase 4 (PSMD4) is an important proteasome ubiquitin receptor and plays a key role in endoplasmic reticulum stress (ERS). However, the study of PSMD4 in esophageal cancer (EC) is relatively rare. Here, we found that the expression of PSMD4 was markedly enhanced in EC tissues and cell lines. The cell counting kit‐8 (CCK‐8) assay showed that overexpression of PSMD4 significantly enhanced Eca109 cell viability, while inhibition of PSMD4 reduced Eca109 cell viability. Knockdown of PSMD4 induced Eca109 cell apoptosis and cell cycle arrest. More importantly, knockdown of PSMD4 significantly enhanced the expression of glucose regulated protein 78, activating transcription factor 6, and p‐protein kinase R‐like ER kinase, indicating an enhanced ERS response in esophageal cancer cells. Compared with the control cells, brefeldin A significantly inhibited the expression of PSMD4 and increased the expression of p53‐upregulated modulator of apoptosis. However, such effects were largely reversed after overexpressing PSMD4 in Eca109 cells, suggesting that silencing PSMD4 could enhance ERS‐induced cell apoptosis. In summary, upregulation of PSMD4 promoted the progression of esophageal cancer mainly by reducing ERS‐induced cell apoptosis.

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Esophageal cancer in high-risk areas of China: research progress and challenges

Cited by 166 publications

References 36 publications

Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells

Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells

A suggested framework for conducting esophageal cancer screening in China

PSMD4 regulates the malignancy of esophageal cancer cells by suppressing endoplasmic reticulum stress

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