Esophageal Gland Duct Adenoma: Immunohistochemical Comparison With the Normal Esophageal Gland and Ultrastractural Analysis

Harada, Oi; Ota, Hiroyoshi; Katsuyama, Tsutomu; Hidaka, Eiko; Ishizaka, Katsuhiko; Nakayama, Jun

doi:10.1097/01.pas.0000213400.64945.9e

Cited by 20 publications

(26 citation statements)

References 8 publications

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“…Antibodies to CK19, p63, smooth muscle actin (SMA)[42], and Ki67 (MIB-1) were used in the dilutions shown in the Supplemental Tables. The Bond Polymer Refine Detection Kit (using a DAB chromogen; Leica Microsystems, Bannockburn, IL) was used as a secondary visualization system.…”

Section: Methodsmentioning

confidence: 99%

Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett’s esophagus

et al. 2014

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The esophageal submucosal glands (SMG) protect the squamous epithelium from insults such as gastroesophageal reflux disease by secreting mucins and bicarbonate. We have observed metaplastic changes within the SMG acini that we have termed oncocytic glandular metaplasia (OGM), and necrotizing sialometaplasia-like change (NSMLC). The aim of this study is to evaluate the associated clinicopathological parameters of, and to phenotypically characterize the SMG metaplasias. Esophagectomy specimens were retrospectively assessed on hematoxylin and eosin sections and assigned to either a Barrett’s esophagus (BE) or non-BE control group. Clinicopathologic data was collected, and univariate analysis and multivariate logistic regression models were performed to assess the adjusted associations with NSMLC and OGM. Selected cases of SMG metaplasia were characterized. SMG were present in 82 esophagi that met inclusion criteria. On univariate analysis, NSMLC was associated with BE (p=0.002). There was no relationship between NSMLC and patient age, sex, tumor size, or treatment history. OGM was associated with BE (p=0.031). No relationship was found between OGM and patient age, sex, or tumor size. On multivariate analysis, BE was independently associated with NSMLC (odds ratio [OR] 4.95, p =0.003). Treatment history was also independently associated with OGM (p =0.029), but not NSMLC. Both NSMLC and OGM were non-mucinous ductal type epithelia retaining a p63-smooth muscle actin co-positive myoepithelial cell layer. NSMLC and OGM were present in endoscopic mucosal resection specimens. Our study suggests that SMG metaplasia is primarily a reflux-induced pathology. NSMLC may pose diagnostic dilemmas in resection specimens or when only partially represented in mucosal biopsies or endoscopic resection specimens.

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Section: Methodsmentioning

confidence: 99%

Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett’s esophagus

et al. 2014

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“…1 Although they appeared to vary in number and/or distribution among individuals, prior studies noted that SMGs clustered at either the proximal or distal esophagus, organizing into longitudinal rows parallel to the long axis of the organ. [3][4][5][6][7][8][9][10][11] Series study focusing on histopathological features of this lesion has not been reported. It was usually described in case reports and named variously.…”

Section: Introductionmentioning

confidence: 99%

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Nie

Shen

et al. 2015

Dis Esophagus

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Esophageal submucosal gland duct adenoma (ESGDA) is a rare tumor. The clinicopathological features of the ESGDA and its precursor lesion have not been comprehensively evaluated. In this study, we aimed at delineating the clinicopathological features of the ESGDA and cyst formation of the esophageal submucosal gland duct (ESGD), as well as their correlations and clinical implications. We identified three cases of ESGDA and 16 cases of cyst formation of the ESGD among 786 endoscopic mucosal resection specimens over a 7-year period. The median patient age was 58 years with a male predominance. These lesions were small submucosal bulges locating at the lower esophagus with a size no more than 1 cm. The main microscopic changes of these lesions included content retention, multilayered epithelium or papillary folds of the ESGD and inflammatory cell infiltration, acidophilic degeneration, hyperplasia or atrophy of the acini. The included cases generally showed moderate to severe microscopic esophagitis. The ESGDA was mainly consisted by multiple glandular cysts covered by two layers of cells. Immunohistochemical results showed that the luminal duct lining cells and basal cells were positive for CK7 and p63, respectively. Both of the two layer cells were positive for HMWCK and negative for CK20, p53, CDX2, MUC5AC, MUC6, MUC2 and MUC1. The proliferation index was very low (1%). The diagnostic criteria of the ESGDA were proposed and, the differential diagnosis was discussed. Cyst formation of the ESGD is considered to be the precursor lesion of the ESGDA, because they have overlapping clinicopathological features with progressive relationship. In addition, the ESGDA have close connection with advance of the GERD and, probably, an increased risk of carcinoma.

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“…Therefore, normal esophageal gland and ducts demonstrated similar immunoreactive patterns as in the breast, prostate, salivary gland and others. Glandular duct adenomas of the esophagus also accompanied myoepithelial cells [10]. However, esophageal cardiac glands did not necessarily contain the myoepithelial cells, consistent with negative immunoreactivity for p63 or CK5/6.…”

Section: Discussionmentioning

confidence: 84%

Adenocarcinoma in the squamous-lined esophagus without Barrett’s mucosa, probably arising from esophageal gland duct

et al. 2014

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Esophageal Gland Duct Adenoma: Immunohistochemical Comparison With the Normal Esophageal Gland and Ultrastractural Analysis

Cited by 20 publications

References 8 publications

Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett’s esophagus

Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett’s esophagus

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Adenocarcinoma in the squamous-lined esophagus without Barrett’s mucosa, probably arising from esophageal gland duct

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