Esophageal schwannoma: Case report and epidemiological, clinical, surgical and immunopathological analysis

Souza, Luiz Carlos de Araújo; Pinto, Thiago David Alves; Cavalcanti, Hugo Oliveira de Figueiredo; Rezende, Alexandre; Nicoletti, Ana Luiza Alves; Leão, Cinthia; Cunha, Vinícius Carvalhêdo

doi:10.1016/j.ijscr.2018.10.084

Cited by 25 publications

(19 citation statements)

References 59 publications

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“…The symptomatic analysis showed that the most frequent symptoms were dysphagia (53.7%), dyspnea (10.4%), cough (4.4%), weight loss (4.4%), and chest pain (4.4%). [ 9 ] Only 1 case reported the tracheal obstruction from a benign esophageal schwannoma till now. [ 10 ] Dysphagia is the most common symptom.…”

Section: Discussionmentioning

confidence: 99%

Benign esophageal schwannoma

Shou

et al. 2020

Medicine

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Rationale: Schwannoma is a tumor of the peripheral nervous system that originated in the Schwann cells of the neural sheath. Esophageal schwannomas are rare esophageal submucosal tumors, comprising approximately 2% of esophageal tumors. Since the symptoms, signs, and images of esophageal schwannoma are not specific, its preoperative diagnosis remains challenging. Patient concerns: A 67-year-old woman visited our department with complaints of gradually developed dysphagia and dyspnea for 4 years. A chest computed tomography scan showed a well-demarcated, enhancing homogeneous tumor measuring 61 × 46 × 60 mm in the upper third of the esophagus. Upper gastrointestinal endoscopy revealed a smooth elevated lesion located 19 to 24 cm from the incisor teeth. An endoscopic ultrasound-guided fine-needle aspiration demonstrated the presence of benign spindle cells. Diagnoses: Histopathologic examination revealed spindle-shaped cells in a fasciculated and disarrayed architecture. The immunohistochemical study showed positivity for S-100 protein antibody and absence of staining for CD117, CD34, smooth muscle actin, and Desmin. These findings confirmed the diagnosis of benign esophageal schwannoma. Interventions: The tumor was considered to be difficult to repair the esophagus by direct anastomosis after tumor resection. Therefore, subtotal esophagectomy and esophagogastrostomy in the right thorax were performed. Outcomes: The patient has been doing well with no recurrence at 36 months after the operation. Lessons: The symptoms and surgical procedures for benign esophageal schwannoma depend on the size and location of the tumor, proper and timely treatment is essential. A definitive diagnosis is confirmed by histology, and complete excision should yield good results.

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Section: Discussionmentioning

confidence: 99%

Benign esophageal schwannoma

Shou

et al. 2020

Medicine

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“…Oesophageal schwannomas more frequently develop in middle‐aged women and in the proximal oesophagus . Symptoms include dysphagia and weight loss.…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of dysphagia with paroxysmal cough

Chand

Ting

Dowling³

2019

GastroHep

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“…Clinical features and diagnostic approach: Dysphagia is, by far, the most common symptom in patients with OSs[ 21 ]. EGDS, EUS and CT scans are useful for correct clinical assessment (Figure 2B )[ 20 , 21 ]. Some OSs have been reported in association with neurofibromatosis type 2[ 20 ].…”

Section: Rare Primary Oesophageal Benign Tumours and Tumours Of Uncermentioning

confidence: 99%

“…OSs are unencapsulated but well-circumscribed tumours that are characterized by spindle cells with microtrabecular architecture. OSs can also present focal cellular pleomorphism with nuclear atypia, rare mitotic figures and a lymphoid infiltrate, also containing germinal centres[ 8 , 21 ]. Gastrointestinal schwannomas usually lack typical features present in soft tissue counterparts, such as encapsulation, nuclear palisading, vascular hyalinization and dilatation[ 8 ].…”

Section: Rare Primary Oesophageal Benign Tumours and Tumours Of Uncermentioning

confidence: 99%

“…Gastrointestinal schwannomas usually lack typical features present in soft tissue counterparts, such as encapsulation, nuclear palisading, vascular hyalinization and dilatation[ 8 ]. On immunohistochemistry, OSs are positive for S100 and SOX10 but negative for CD34, SMA, desmin and CD117[ 21 ].…”

Section: Rare Primary Oesophageal Benign Tumours and Tumours Of Uncermentioning

confidence: 99%

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Histopathological landscape of rare oesophageal neoplasms

Businello

Pozzo

Sbaraglia

et al. 2020

WJG

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The landscape of neoplastic pathology of the oesophagus is dominated by malignancies of epithelial origin, in particular by oesophageal adenocarcinoma and oesophageal squamous cell carcinoma. However, several other histopathological variants can be distinguished, some associated with peculiar histopathological profiles and prognostic behaviours and frequently underrecognized in clinical practice. The aim of this review is to provide a comprehensive characterization of the main morphological and clinical features of these rare variants of oesophageal neoplastic lesions.

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Esophageal schwannoma: Case report and epidemiological, clinical, surgical and immunopathological analysis

Abstract: HighlightsThe schwannoma of the esophagus is a rare case report.We present a review of the main characteristics of this disease.Aspects covered epidemiological, clinical, surgical, histopathological and immunohistochemical.

Cited by 25 publications

References 59 publications

Benign esophageal schwannoma

Benign esophageal schwannoma

An unusual cause of dysphagia with paroxysmal cough

Histopathological landscape of rare oesophageal neoplasms

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