HighlightsThe schwannoma of the esophagus is a rare case report.We present a review of the main characteristics of this disease.Aspects covered epidemiological, clinical, surgical, histopathological and immunohistochemical.

We report a case of ultrasound-guided ex vivo oocyte retrieval for fertility preservation in a woman with bilateral borderline ovarian tumor, for whom conventional transvaginal oocyte retrieval was deemed unsafe because of the increased risk of malignant cell spillage. Ovarian stimulation with gonadotropins was performed. Surgery was scheduled according to the ovarian response to exogenous gonadotropic stimulation; oophorectomized specimens were obtained by laparoscopy, and oocyte retrieval was performed ∼ 37 hours after the ovulatory trigger. The sum of 20 ovarian follicles were aspirated, and 16 oocytes were obtained. We performed vitrification of 12 metaphase II oocytes and 3 oocytes matured in vitro. Our result emphasizes the viability of ex vivo mature oocyte retrieval after controlled ovarian stimulation for those with high risk of malignant dissemination by conventional approach.

Background: Inhibitors of the epidermal growth factor (EGFR) represent an effective therapeutic option for patients with metastatic colorectal carcinoma, free of activating mutations in KRAS and NRAS. However, the research of mutations is of high cost and scarcely accessible. The expression of the EGFR by immunohistochemistry predicting the mutation status of the expanded RAS (KRAS and NRAS), may allow treatment by a diagnostic method less costly and more accessible. Aim: Investigate the correlation between the clinical-pathological data, the cytoplasmic-membrane expression of the EGFR and the mutational status of the expanded RAS. Method: A total of 139 patients with colorectal carcinoma from the archives of Instituto Goiano de Oncologia e Hematologia were evaluated. Results: Mutation of the expanded RAS was detected in 78 (56.1%) cases. The EGFR expression was stratified in 23 (16.5%) “positive”, 49 (35.2%) "negative" and 67 (48.2%) "uncertain". No significant correlation was found between the mutational status of the RAS and the EGFR expression in comparison to age, gender, location, histological type, histological grade and stage. From 23 "positive” cases, 21 (91.3%) showed wild-type RAS gene, and 49 "negative”, 41 (83.7%) presented mutation, resulting in a strong association between EGFR "positive", "negative” groups and the mutational status of the RAS (p<0.001), with 86.1% of accuracy. Conclusions: The cytoplasmic-membrane analysis of the EGFR expression stratified into "positive", "negative" and "uncertain" predicts mutational status of the RAS in 51.7% of the cases (p<0.001), with 86.1% of accuracy.

Introduction and objectives:We report a rare case of localized primary bladder amyloidosis, and we conducted a literature review. Materials and methods:A 70-year-old man with gross haematuria and storage bladder symptoms was diagnosed with primary bladder amyloidosis with clinical and radiological features of bladder tumor. A comprehensive review of English literature was done. PubMed, NCBI and Science Direct were searched using the following search terms: "primary"; "Bladder"; "Amyloidosis".Results: Primary localized bladder amyloidosis is a rare and benign urological disease with approximately 210 reported cases in the English literature. It is usually of the AL type and commonly presents with gross painless haematuria and storage bladder symptoms, mimicking bladder malignancy. Imaging investigations such as ultrasound scan, CT scan and MRI are not diagnostic, whereas histopathological examination confirms the diagnosis. Transurethral resection of the bladder lesion is the treatment of choice; however local recurrence is common (50% of cases). Conclusion:Localised bladder amyloidosis is almost always of AL type and does not progress to systemic amyloidosis. Treatment is not curative and recurrence is common, hence surveillance cystoscopy is required.