Esophageal Small-cell Carcinoma with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Abstract

Small-cell carcinoma (SCC) of the esophagus is rare, and its clinical characteristics remain poorly understood. A 54-year-old man was given a diagnosis of esophageal SCC and underwent esophagectomy. Four months after surgery, he was admitted to our hospital because of rapidly developing hyponatremia. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) due to extensive recurrence of SCC was diagnosed. Combined chemotherapy with irinotecan and cisplatin has dramatically reduced metastatic tumors, and it was concomitantly effective for SIADH. This case demonstrates that esophageal SCC could induce SIADH as a paraneoplastic syndrome and that the above combined chemotherapy was feasible and effective.

Progress in the treatment of esophageal neuroendocrine carcinoma

“…14 However, a small number of cases can be identified as hormone-related syndromes, such as antidiuretic hormone secretion disorder syndrome. 15 …”

Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Associated with Myeloma and Syndrome of Inappropriate Antidiuretic Hormone Secretion in an Elderly Man

“…This association is even greater with small cell lung cancer (10–45%) . Esophageal carcinoma; ear, nose, and throat cancer; and myeloma are other cancers in which SIADH has been reported …”

Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema

“…Las características que sugieren el diagnóstico de SIADH son las siguientes: sodio urinario superior a 40 mmol/L o una osmolalidad urinaria superior a 100 mOsm/kg de agua, con función tiroidea normal y cortisol sérico normal (3, 62). Este síndrome se ha vinculado más frecuentemente con cáncer de pulmón de células pequeñas, pero también se ha encontrado en tumores del tubo digestivo -los más frecuentes son los de esófago, estómago, pán-creas, duodeno, colon y recto- (62,(64)(65)(66).…”