Esophageal stricture secondary to candidiasis without underlying disease

Abstract

Candidiasis of the esophagus progressing to stricture formation in a 74-year-old male is reported. Esophageal candidiasis develops in the presence of various predisposing conditions such as long-standing administration of antibiotics or corticosteroids, and malignancy. The first endoscopic examination of this patient revealed unusual multiple black plaques in the esophagus. Despite intensive exploration, no predisposing factors were found. The stricture was progressive, despite the administration of adequate antifungal therapy, and its presence necessitated several attempts at dilatation. Case reports of esophageal candidiasis without underlying disease are very rare.

Recurrent Candida-Associated Esophageal Strictures in an Immunocompetent Patient

“… 6 Clinical diagnosis is based on characteristic symptoms in at-risk patients, with endoscopic findings of white plaque-like membranes in the esophagus; definitive diagnosis is contingent on biopsy findings of Candida . 1 The acute phase of esophagitis involves mucosal erythema with white pseudomembranes consisting of necrotic debris and fungal species, which progresses to granulated friable mucosa and ulcers. 6 Stricturing may result from ongoing inflammation.…”

Esophageal Stricture Secondary to Candidiasis in a Child with Glycogen Storage Disease 1b

“…Fungal esophagitis has been shown induce sloughing of the esophageal mucosa, resulting in stricture, but this condition is very rare [ 1 2 3 4 5 6 ]. In a pediatric case, a 3-year-old leukemic patient received chemotherapy and radiotherapy.…”

“…Our patient had neutropenia for a long time and suffered from recurrent infection and complications including bronchiectasis, esophageal candidiasis and adhesive tympanic membrane, although he received the appropriate antibiotics and G-CSF. However, recurrent esophageal candidiasis induced mucosal glandular inflammation and resulted in stricture formation [ 2 ].…”

“…However, candida esophagitis induced stricture is a very rare complication [ 1 2 3 4 5 6 ]. It is well known that frequent infections can occur in glycogen storage disease (GSD) 1b patients, but thus far, candida esophagitis has not been reported in GSD 1b patients.…”

Candidiasis esofágica en pacientes inmunocompetentes: Estudio clínico e inmunológico

“…En nuestro medio, en el único estudio que aborda el tema, Maggiolo y Klinger 7 presentaron 25 casos de CE, de los que sólo 3 fueron catalogados como sanos; en los 22 restantes se encontró alguna patología predisponente, principalmente neoplásica, uso de tratamiento esteroidal o inmunosupresor. No obstante, en otras series, se describen pacientes a los que [8][9][10] . En este trabajo se consideró criterio de exclusión patologías reconocidamente inmunosupresoras y, a partir de ello, se efectuó un completo estudio inmunológico humoral y celular.…”