Esophageal ulceration complicating doxycycline therapy

Al-Mofarreh, Mohammad A; Mofleh, Ibrahim A Al

doi:10.3748/wjg.v9.i3.609

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…EP complicates caustic burns mostly when management is delayed. More than 100 pharmaceutical substances have been incriminated in the onset of esophageal lesions [14], and notably those induced by the encapsulated form of doxycycline [15]. EPs have been reported after difficult endotracheal intubation [16], cardiac endoscopic sonography [17], or insertion of nasogastric [18] or Blakemore tubes [19].…”

Section: Posttrauma Perforationsmentioning

confidence: 99%

Esophageal perforations

Chirica

Champault

Dray

et al. 2010

Journal of Visceral Surgery

174

166

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The incidence of esophageal perforation (EP) has risen with the increasing use of endoscopic procedures, which are currently the most frequent causes of EP. Despite decades of clinical experience, innovations in surgical technique and advances in intensive care management, EP still represents a diagnostic and therapeutic challenge. EP is a devastating event and mortality hovers close to 20%. Ambiguous presentations leading to misdiagnosis and delayed treatment and the difficulties in management are responsible for the high morbidity and mortality rates. A high variety of treatment options are available ranging from observational medical therapy to radical esophagectomy. The potential role of interventional endoscopy and the use of stents for the treatment of EP seem interesting but remain to be evaluated. Surgical primary repair, with or without reinforcement, is the preferred approach in patients with EP. Prognosis is mainly determined by the cause, the location of the injury and the delay between perforation and initiation of therapy.

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Section: Posttrauma Perforationsmentioning

confidence: 99%

Esophageal perforations

Chirica

Champault

Dray

et al. 2010

Journal of Visceral Surgery

174

166

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“…Although impressive, the numbers are considered by experts in the field to be quite small compared with the estimated case frequency [1]. Doxycycline induced oesophageal injury (DIEI) has contributed to 27% of the global burden [3]. No cases have been reported to date to the National Pharmacovigilance Unit in Sri Lanka, which limits the ability to assess the epidemiology of this iatrogenic disease as doxycycline is used commonly in our country.…”

Section: Introductionmentioning

confidence: 99%

Oesophageal injury suspected to be due to doxycycline ingestion

Fernandopulle¹,

Navarathne

2011

Ceylon Med. J.

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Doxycycline induced oesophageal injury (DIEI) has contributed to 27% of the global burden of drug induced oesophageal injury. We report 21 cases of DIEI detected over a one year period.Cases were defined as sudden onset -chest pain, dysphagia and odynophagia within a few hours to days after taking doxycycline, confirmed by UGIE, with improvement on withdrawal of doxycycline. The majority was in the 20 -30 year age group and was female. The commonest symptoms were dysphagia and odynophagia. The mean time to symptoms from ingestion of doxycycline was 2.5 days. Majority of ulcers were in the mid oesophagus. Our case series highlights a preventable adverse drug reaction, which may have been avoided by giving simple advice to the patient.

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“…Approximately 100 types of medication are reported to cause esophageal injuries . Drug‐induced esophageal injuries are classified by their etiology as follows: (i) injury resulting from acidic antibiotics, (ii) chemical esophagitis caused by bisphosphonates such as alendronate, (iii) hyperosmotic injury caused by potassium chloride or quinidine, and (iv) distal esophagitis associated with nonsteroidal anti‐inflammatory drugs in patients with gastroesophageal reflux disease .…”

mentioning

confidence: 99%