Esparganosis cerebral. Presentación de un caso pediátrico

Mc, Jones; Mr, Agosti; D'Agustini, Marcelo; Uriarte,; Drut, R

doi:10.5546/aap.2013.e1

Cited by 10 publications

(5 citation statements)

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“…The three cases were diagnosed in individuals from bordering countries. Two of the cases occurred in adults, one with brain localization (Boero et al, 1991) and the other with cutaneous localization (De Roodt et al, 1993), whereas the third case occurred in a child (Jones et al, 2013). In Argentina, no local cases of sparganosis have been detected yet.…”

Section: Resultsmentioning

confidence: 99%

Research Note. Cox-1 gene sequence of Spirometra in Pampas foxes from Argentina

et al. 2015

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SummaryThe parasites of the genus Spirometra belong to one of the twelve genera of the family Diphyllobothriidae, with several species of zoonotic importance whose defi nitive hosts are carnivorous mammals. In Argentina, few reports have described these parasites in wild carnivores. Morphological studies of the adult stage obtained from necropsy allow the distinction between Diphyllobothrium and Spirometra. A less invasive method of identifi cation is the analysis of the parasite eggs; however, the morphometric similarities between close genera and species and alterations in egg preservation affect the identifi cation. In Argentina, molecular tools have been used as a non-invasive and accurate method to increase the information about Spirometra and to improve its identifi cation. In the present study, DNA was extracted from Spirometra eggs from Pampas foxes and a 450-bp fragment of the mitochondrial cytochrome C oxidase subunit 1 (cox1) gene was sequenced. The sequence obtained, which is the fi rst Spirometra DNA sequence from Argentina, was deposited at GenBank. Comparison by BLASTN analysis between the sequence obtained and the sequences from GenBank showed 93 % identity with S. proliferum and 89% with S. erinaceieuropaei.

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Section: Resultsmentioning

confidence: 99%

Research Note. Cox-1 gene sequence of Spirometra in Pampas foxes from Argentina

et al. 2015

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“…Sparganosis is a rare parasitic disease caused by an infection by the second-stage larvae of Spirometra mansoni , also called “sparganum”. There is a higher prevalence of this disease in East Asian countries, such as China, Thailand, Korea and Japan, although sparganosis also occurs occasionally in Europe, North Americaand South America[1–8].…”

Section: Introductionmentioning

confidence: 99%

Follow-up study of high-dose praziquantel therapy for cerebral sparganosis

Zhang

Zou

et al. 2019

PLoS Negl Trop Dis

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BackgroundCerebral sparganosis is the most serious complication of human sparganosis. Currently, there is no standard for the treatment of inoperable patients. Conventional-dose praziquantel therapy is the most reported treatment. However, the therapeutic outcomes are not very effective. High-dose praziquantel therapy is a useful therapeutic choice for many parasitic diseases that is well tolerated by patients, but it has not been sufficiently evaluated for cerebral sparganosis. This study aims to observe the prognoses following high-dose praziquantel therapy in inoperable patients and the roles of MRI and peripheral eosinophil absolute counts during follow-up.MethodologyBaseline and follow-up epidemiological, clinical, radiological and therapeutic data related to 10 inoperable patients with cerebral sparganosis that were treated with repeated courses of high-dose praziquantel therapy, with each course consisting of 25 mg/kg thrice daily for 10 days were assessed, followed by analyses of the prognoses, MRI findings and peripheral eosinophil absolute counts.Principal findingsBaseline clinical data: the clinical symptoms recorded included seizures, hemiparesis, headache, vomiting and altered mental status. Peripheral blood eosinophilia was found in 3 patients. The baseline radiological findings were as follows. Motile lesions were observed in 10 patients, including aggregated ring-like enhancements, tunnel signs, serpiginous and irregular enhancements. Nine of the 10 patients had varying degrees of white matter degeneration, cortical atrophy and ipsilateral ventricle dilation. The follow-up clinical data were as follows. Clinical symptom relief was found in 8 patients, symptoms were eliminated in 1 patient, and symptoms showed no change from baseline in 1 patient. Peripheral blood eosinophilia was found in 2 patients. The follow-up radiological findings were as follows. Motile lesions that were transformed into stable, chronic lesions were found in 8 patients, and motile lesions that were eliminated completely were found in 2 patients.ConclusionsHigh-dose praziquantel therapy for cerebral sparganosis is effective. The radiological outcomes of motile lesions are an important indicator during the treatment process, especially during follow-ups after clinical symptoms have improved. Peripheral eosinophil absolute counts cannot be used as an effective prognostic indicator.

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“…Two cases occurred in adults; one with brain localization (Boero et al, 1991) and the other with cutaneous localization (De Roodt et al, 1993). In addition, Jones et al (2013) have reported one case of Cerebral Sparganosis in a child. But all this cases were individuals of bordering countries.…”

Section: Discussionmentioning

confidence: 99%