The paper presents data on studying biocompatibility and tissue response in the implantation zone of collagenstimulating coated hernio implants. Endoprosthesis of the anterior abdominal wall was carried out in a supraponeurotic manner on rats of the Vistar breed. When using ascorbic acid coated hernioimplant, less pronounced reactive changes were observed in the surrounding tissues, manifested by the absence of a significant number of inflammatory cells, the predominance of fibroblastic elements in the field of view, the activation of which contributed to the early engraftment of the hernioimplant as a result of stimulation of collagenesis. Therefore, it was concluded that the most optimal is hernioimplant coated with ascorbic acid.