Esporotricose urbana: epidemia negligenciada no Rio de Janeiro, Brasil

Silva, Margarete Bernardo Tavares da; Costa, Mônica Motta de Mattos; Torres, Carla Carrilho da Silva; Galhardo, Maria Clara Gutierrez; Valle, Antônio Carlos Francesconi do; Magalhães, Mônica de Avelar Figueirêdo Mafra; Sabroza, Paulo Chagastelles; Oliveira, Rosely Magalhães de

doi:10.1590/s0102-311x2012001000006

Cited by 126 publications

(102 citation statements)

References 22 publications

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“…The difficulties regarding the treatment of feline sporotrichosis, such as prolonged treatment time, high cost, drug dosage forms and isolation of affected animals, often contribute to their abandonment, which eventually die [7–12]. Currently, soil contamination by infected carcasses represents a major environmental concern because it can greatly increase the spread of fungi and hold back the control of this mycosis, closing the cat-environment-man cycle [10, 13]. …”

Section: Introductionmentioning

confidence: 99%

“…Sporotrichosis has been described in the last decades as one of the most important zoonosis and also as a neglected disease, having reached an epidemic status in the state of Rio de Janeiro [7, 9, 13] with over 4700 domestic felines [14] and around 4000 humans [13] affected since the mid-90s. Until 2009, approximately 3244 cats, 2200 humans and 120 dogs presenting this subcutaneous mycosis were reported by the most important sporotrichosis reference center in Rio de Janeiro, the National Institute of Infectious Diseases of the Oswaldo Cruz Foundation (IPEC-FIOCRUZ) [10].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is a pressing need for larger investigations in order to provide a broader view of sporotrichosis in its different aspects such as epidemiology, fungal biology and environmental particularities of transmission within this state. Thus, it is clear that sporotrichosis has reached an epidemic magnitude in the only Brazilian state wherein notification is compulsory and the disease is considered an important zoonosis [8, 13, 15]. Additionally, although in reduced numbers compared to Rio de Janeiro, sporotrichosis zoonotic transmission by domestic felines have been reported in other Brazilian states [16].…”

Section: Introductionmentioning

confidence: 99%

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Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations

et al. 2018

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BackgroundSporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas.ResultsThree hundred and seventy-one cats were included in two groups: 175 healthy cats [CRG] and 196 cats showing lesions suggesting sporotrichosis [SSG]. Mycological diagnosis allowed SSG animals to be divided in positive [104 cats; +SG] and negative [92 cats; -SG] groups. Nails, oral mucosa and lesions swabs were submitted to culture and potential colonies were subculture for micromorphologycal analysis, dimorphism and molecular tests. In the CRG, only one cat was colonized in the oral cavity [0.57%]; in the -SG group, four animals showed colonization of the nail and/or oral cavity [4.3%]; while the highest frequency of colonization [39.4%] was observed in the +SG. All molecularly typed isolates were identified as S. brasiliensis.ConclusionThe results obtained here indicate that healthy cats have a minor role in sporotrichosis transmission within the state of Rio de Janeiro. Conversely, a higher participation of diseased feline in sporotrichosis transmission was evidenced, especially by the colonization of their oral cavity. Sporothrix brasiliensis equally affects and colonizes animals from distinct Rio de Janeiro state areas. Thus, we hypothesize that sporotrichosis is a uniform endemic throughout the state, whose transmission depends mainly on the contact with cats with sporotrichosis. Since Rio de Janeiro displays a world unique epidemic model of the disease, not fully understood, data on the infected and non-infected animals can be of major importance for future strategies of sporotrichosis prevention and control. Finally, considering the importance of the current concept of “one health”, the experience here observed can be helpful for distinct epizootias and/or zoonosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations

et al. 2018

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“…Classicamente, a doença possuía maior casuística nos indivíduos do sexo masculino, sendo esse fato relacionado diretamente às atividades ocupacionais, em consequência do maior contato com o solo em trabalhos como jardinagem, agricultura e mineração (LACERDA FILHO et al, 1999). Entretanto, estudos no estado do Rio de Janeiro, demonstraram a predominância da afecção em mulheres (BARROS et al, 2004;SILVA et al, 2012). Barros et al (2004) citam que em relação as atividades ocupacionais houve mais relatos de enfermidade em domésticas (30%), estudantes (18%), médicos veterinários (5%), trabalhadores rurais (2%), e 7% em outras profissões como, por exemplo, vendedores, costureiras e advogados.…”

Section: Introductionunclassified

“…A esporotricose é considerada uma importante enfermidade emergente, com isso é necessário realizar ações de saúde pública de forma urgente, visando o controle da doença, especialmente em áreas endêmicas (SILVA et al, 2012). Na medicina humana são crescentes os casos de pacientes com moléstias imunossupressoras associadas à micose.…”

Section: Introductionunclassified

Terapêutica Da Esporotricose: Revisão

Rosa

Meinerz²,

Osório³

et al. 2018

SCI. ANIM. HEALTH

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RESUMOesporotricose é considerada uma micose emergente de importância para a saúde pública, especialmente devido aos frequentes relatos zoonóticos envolvendo o felino doméstico. São crescentes as casuísticas animal e humana da micose, assim como os relatos de casos refratários à terapia convencional, principalmente nos casos de esporotricose felina. Nesse sentido, o trabalho descreve e discute as opções terapêuticas mais utilizadas, além de citar alternativas disponíveis para o tratamento da micose. Os resultados indicam ser o itraconazol o fármaco de primeira escolha, especialmente nos felinos domésticos, tendo o iodeto de potássio, terbinafina e cetoconazol como alternativas de tratamento. O estudo ressalta o uso da anfotericina B nos casos resistentes, assim como descreve as intervenções cirúrgicas e a termoterapia nos casos de falha terapêutica e quando as lesões eram localizadas. Com esses resultados o estudo conclui que dentre as terapias utilizadas para a esporotricose nos animais, o itraconazol mesmo com os crescentes relatos de falhas terapêuticas, permanece sendo o fármaco de primeira escolha, especialmente nos casos da micose em felinos. As demais opções são utilizadas nos casos mais graves da micose ou em situações em que o itraconazol não se mostra efetivo frente ao agente. Palavras

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Deep Fungal Infections

García‐Romero¹

2019

Harper's Textbook of Pediatric Dermatology

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Esporotricose urbana: epidemia negligenciada no Rio de Janeiro, Brasil

Cited by 126 publications

References 22 publications

Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations

Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations

Terapêutica Da Esporotricose: Revisão

Deep Fungal Infections

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