Essential factors associated with hepatic angiogenesis

A glyphosate-based herbicide induces histomorphological and protein expression changes in the liver of the female guppy Poecilia reticulata

“…Concomitantly, increased expression of LReO_3, known as the LTR (long terminal repeated) retro-element of the ricefish O. latipes, which is found in the class I region of the histocompatibility complex (MHC) (Matsuo and Nonaka, 2004), was observed in GBHexposed fish, suggesting that this complex was increased in response to the development and advancement of tumours (Wang et al, 1994). Moreover, the decreased expression of brain angiogenesis inhibitor 3 (BAI3) (Duda et al, 2002) may induce the formation of new vascular structures from preexisting vessels (Das and Vasudevan, 2007). This process occurs in various organs in a range of pathological situations, promoting the development of fibrogenesis and growth and development of cancers in the liver (Fern andez et al, 2009), forming new blood vessels that are routes for the supply of nutrients and oxygen to these tumours.…”

Targeting angiogenesis in pancreatic cancer: rationale and pitfalls

“…Heparanase is another enzyme that plays a role in the proteolysis of the extracellular matrix by degrading heparan sulfate found on HSPGs, thereby releasing stored growth factors which can then stimulate angiogenesis [83,84]. In contrast, angiostatin, a cleaved product of plasminogen, and endostatin, the C-terminal fragment of collagen, both suppress angiogenesis by specifically inhibiting endothelial cell proliferation and migration [85][86][87]. Attenuated expression of angiogenesis suppressors can lead to enhanced tumor angiogenesis by allowing the actions of pro-angiogenic factors to proceed without interference by signaling pathways that attenuate angiogenesis.…”

Functional Genetic Variants of TNFSF15 and Their Association with Gastric Adenocarcinoma: A Case-Control Study

“…TNFSF15 shares 20–30% identity (or similarity) in amino acid sequence with other TNF family members and has similar functions [13]–[15]. TNFSF15 is involved in numerous cellular processes including the suppression of neovascularization which is essential for tumor progression and spread [12], [16], [17]. Over-expression of TNFSF15 gene has been shown to inhibit the development of multiple tumor types [18], [19].…”