Essential Oil and Antifungal Therapy

Moghaddam, Mohammad; Mehdizadeh, Leila

doi:10.1007/978-81-322-2782-3_2

Cited by 14 publications

(7 citation statements)

References 148 publications

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“…Among the volatile constituents, the phenols are considered to be the most potent antifungal agents. These compounds alter the microbial cell membrane integrity causing the loss of essential cytoplasmic constituents, impair the fungal enzyme systems and interfere with the cell wall synthesis …”

Section: Resultsmentioning

confidence: 99%

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Aprotosoaie

Ciocârlan

Brebu³

et al. 2019

Flavour & Fragrance J

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Thymus species are important aromatic, medicinal and culinary plants with a significant economic value. This study evaluated for the first time the chemical composition and in vitro bioactivities of the essential oils (EOs) from five Moldavian Thymus species (T. vulgaris, T. × citriodorus, T. calcareus) and cultivars (T. vulgaris ‘Faustini’, T. citriodorus ‘Aureus’). The main compounds in Thymus EOs were: thymol in T. vulgaris and T. calcareus EOs (55.44% and 55.45%, respectively), lavandulol in T. × citriodorus EO (54.27%), and geraniol in T. citriodorus ‘Aureus’ and T. vulgaris ‘Faustini’ EOs (60.31% and 31.45%, respectively). T. vulgaris and T. calcareus EOs showed the most potent antioxidant activities (EC50=0.003 mg/mL in ABTS radical cation scavenging assay) and exhibited significant inhibitory effects against aflatoxin‐producing Aspergillus flavus fungus (MIC=0.25 μL/mL). At doses that provided micromolar concentrations of thymol, T. vulgaris and T. calcareus EOs acted genoprotective at preventive and interventional levels against H2O2‐induced genomic damage in V79 cells, the former being more active (6.21% and 5.52% vs. 25.13% and 7.26% tail DNA in pre‐ and post‐treatment protocols, respectively). The genoprotective effects may be ascribed to antioxidant potential and, possibly, to stimulation of DNA repair processes. The Moldavian Thymus species are valuable resources of bioactive EOs for pharmaceutical and food industries (T. vulgaris, T.calcareus) but also for flavor industry and perfumery (T. × citriodorus, T. citriodorus ‘Aureus’, T. vulgaris ‘Faustini’).

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Section: Resultsmentioning

confidence: 99%

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Aprotosoaie

Ciocârlan

Brebu³

et al. 2019

Flavour & Fragrance J

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“…In the swine industry, compound feed is stored for up to 3 mo before it is used. The free form of EO is vulnerable to oxidation by air and light ( Moghaddam and Mehdizadeh, 2016 ). Furthermore, a study from Luo et al (2005) showed that there are some mineral sources, including copper in the animal feed, which can accelerate the oxidation of bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of lipid matrix microencapsulation for intestinal delivery of thymol in weaned pigs

Choi

Wang

Ammeter

et al. 2019

Translational Animal Science

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Essential oils (EO) are defined as plant-derived natural bioactive compounds, which can have positive effects on animal growth and health due to their antimicrobial and antioxidative properties. However, EO are volatile, can evaporate quickly, and be rapidly absorbed in the upper gastrointestinal tract. Also, due to their labile nature, the stability of EO during feed processing is often questionable, leading to variations in the final concentration in feed. Encapsulation has become one of the most popular methods of stabilizing EO during feed processing, storage, and delivery into the lower gut. The objectives of the present study were to 1) evaluate the stability of thymol microencapsulated in combination with organic acids in commercially available lipid matrix microparticles during the feed pelleting process and storage; 2) validate and demonstrate the slow release of thymol from the lipid matrix microparticles in a simulated pig gastric fluid (SGF) and a simulated pig intestinal fluid (SIF); and 3) evaluate in vivo release of thymol from the lipid matrix microparticles along the pig gut. The results showed that thymol concentration was not significantly different in the mash and pelleted feeds (P > 0.05). In the in vitro study, 26.04% thymol was released in SGF, and the rest of the thymol was progressively released in SIF until completion, which was achieved by 24 h. The in vivo study showed that 15.5% of thymol was released in the stomach, and 41.85% of thymol was delivered in the mid-jejunum section. Only 2.21% of thymol was recovered in feces. In conclusion, the lipid matrix microparticles were able to maintain the stability of thymol during a feed pelleting process and storage and allow a slow and progressive intestinal release of thymol in weaned pigs.

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“…Aunque poseen dos o tres componentes principales, los cuales están en una concentración más alta en comparación con los demás (entre un 20-70%). Entre sus principales compuestos se encuentran: compuestos alifáticos de bajo peso molecular (alcanos, alcoholes, aldehídos, cetonas, ésteres y ácidos), terpenos (monoterpenos, sesquiterpenos) y fenilpropanos (Acero-Godoy et al, 2019;Aguilar-Veloz et al, 2020;Allenspach et al, 2020;Aziz et al, 2018;Chouhan et al, 2017;Moghaddam & Mehdizadeh, 2016;Nazzaro et al, 2017; No obstante, expone al AE a mayor cantidad de modificaciones químicas debido a la exposición prolongada de los compuestos a altas temperaturas por largos periodos de tiempo (1-10 horas), por lo que en algunos casos es necesaria una re-destilación, es por esto, que se han realizado al igual que con la hidrodestilación modificaciones para mejorar esta metodología, como son tratamientos previos con enzimas degradadoras de la pared celular y calentamiento asistido por microondas; los cuales mejoran la calidad de los AE y evitan las modificaciones químicas (Oktavianawati, 2020;Roohinejad et al, 2017;Stratakos & Koidis, 2016).…”

Section: Aceites Esencialesunclassified

Control alternativo de Fusarium oxysporum Schltdl y Pectobacterium carotovorum (Jones) Waldee et al., mediante el uso de aceites esenciales como una alternativa biológica

Monroy¹,

Godoy²

2021

Rev E&T

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Los marchitamientos vasculares producidos por Fusarium oxysporum Schltdl y la podredumbre blanda bacteriana por Pectobacterium carotovorum (Jones) Waldee et al., son enfermedades de importancia para diferentes tipos de cultivos como hortalizas, frutas y cereales; ocasionando pérdidas económicas y por sobrevivir en el suelo por largos periodos de tiempo, por lo que su control es difícil. El uso de plaguicidas sintéticos ha sido la tradicional para combatirlos, las consecuencias a largo plazo por su acumulación en el medio han tomado relevancia. El uso de alternativas biológicas extraídas de plantas empieza a destacarse como un método alternativo de control. En esta revisión, se busca hacer una recopilación bibliográfica de la capacidad de los aceites esenciales extraídos de las plantas aromáticas, como tomillo, menta, clavo, entre otros, y sus efectos como posibles agentes de control de estos patógenos, sus capacidades antimicrobianas y antifúngicas, destacando a su vez su forma de acción, los métodos, y las concentraciones que han demostrado efecto sobre los patógenos descritos.

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Essential Oil and Antifungal Therapy

Cited by 14 publications

References 148 publications

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Evaluation of lipid matrix microencapsulation for intestinal delivery of thymol in weaned pigs

Control alternativo de Fusarium oxysporum Schltdl y Pectobacterium carotovorum (Jones) Waldee et al., mediante el uso de aceites esenciales como una alternativa biológica

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