Essential oil from fruit of <i>Xylopia langsdorffiana</i>: antitumour activity and toxicity

Moura, Ana Paula Gomes e; Beltrão, Daiene Martins; Pita, João Carlos Lima Rodrigues; Xavier, Aline Lira; Brito, Monalisa Taveira; Sousa, Tatyanna Kélvia Gomes de; Batista, Leônia Maria; Carvalho, João Ernesto de; Ruiz, Ana Lúcia Tasca Góis; Torre, Adriana Della; Duarte, Marcelo Cavalcante; Tavares, Josean Fechine; Silva, Marcelo Sobral da; Sobral, Marianna Vieira

doi:10.1080/13880209.2016.1211154

Cited by 15 publications

(11 citation statements)

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“…In addition, essential oils and their components, especially monoterpenes and phenylpropanoids, have shown antitumor activity [5–7, 39, 40]. Some of the constituents present in EOM are described in the literature as having significant antitumor activity, specifically limonene [41], β-caryophyllene [42].…”

Section: Discussionmentioning

confidence: 99%

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Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Rolim

Meireles

Batista

et al. 2017

BMC Complement Altern Med

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BackgroundThe essential oil from Mesosphaerum sidifolium (L’Hérit.) Harley & J.F.B.Pastore (syn. Hyptis umbrosa), Lamiaceae (EOM), and its major component, have been tested for toxicity and antitumor activity.MethodsEOM was obtained from aerial parts of M. sidifolium subjected to hydro distillation, and gas chromatography-mass spectrometry was used to characterize the EOM chemical composition. The toxicity was evaluated using haemolysis assay, and acute toxicity and micronucleus tests. Ehrlich ascites carcinoma model was used to evaluate the in vivo antitumor activity and toxicity of EOM (50, 100 and 150 mg/kg), and fenchone (30 and 60 mg/kg) after 9 d of treatment.ResultsThe EOM major components were fenchone (24.8%), cubebol (6.9%), limonene (5.4%), spathulenol (4.5%), β-caryophyllene (4.6%) and α-cadinol (4.7%). The HC50 (concentration producing 50% haemolysis) was 494.9 μg/mL for EOM and higher than 3000 μg/mL for fenchone. The LD50 for EOM was approximately 500 mg/kg in mice. The essential oil induced increase of micronucleated erythrocytes only at 300 mg/kg, suggesting moderate genotoxicity. EOM (100 or 150 mg/kg) and fenchone (60 mg/kg) reduced all analyzed parameters (tumor volume and mass, and total viable cancer cells). Survival also increased for the treated animals with EOM and fenchone. For EOM 150 mg/kg and 5-FU treatment, most cells were arrested in the G0/G1 phase, whereas for fenchone, cells arrested in the S phase, which represents a blockage in cell cycle progression. Regarding the toxicological evaluation, EOM induced weight loss, but did not induce hematological, biochemical or histological (liver and kidneys) toxicity. Fenchone induced decrease of AST and ALT, suggesting liver damage.ConclusionsThe data showed EOM caused in vivo cell growth inhibition on Ehrlich ascites carcinoma model by inducing cell cycle arrest, without major changes in the toxicity parameters evaluated. In addition, this activity was associated with the presence of fenchone, its major component.

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Section: Discussionmentioning

confidence: 99%

“…Among them, essential oils from plants have been useful in cancer prevention and treatment [5–7]. Its effects are associated with antioxidant, antimutagenic, antiproliferative, and immunostimulatory properties, besides modulating multidrug resistance [8].…”

Section: Introductionmentioning

confidence: 99%

Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Rolim

Meireles

Batista

et al. 2017

BMC Complement Altern Med

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“…A variety of interesting pharmacological properties have been attributed to αpinene, including anti-inflammatory, bronchodilator, hypoglycemic, sedative, antioxidant, and broadspectrum antibiotic activities (Mercier et al, 2009;Violante et al, 2012;Da Silva et al, 2012). Previous studies have reported the presence of α-pinene in the essential oils obtained from Annonaceae family, such as Polyalthia korintii (leaf oil: 43.2%) (Sherin et al, 2018), Guatteria costaricensis (leaf oil: 36.3%) (Palazzo et al, 2009), and Xylopia langsdorffiana (fruit oil: 34.6%) (Moura et al, 2016). Meanwhile, germacrene D was also present as the predominant component in the oil.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and acetylcholinesterase inhibition of the essential oil of Cyathocalyx pruniferus (Maingay ex Hook.f. & Thomson) J.Sinclair

Salleh

Khamis

Nadri

et al. 2020

Natural Volatiles and Essential Oils

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The chemical composition and acetylcholinesterase inhibitory activity of the essential oil from the leaf of Cyathocalyx pruniferus growing in Pahang, Malaysia was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of thirty chemical components (95.5%) were successfully identified in the essential oil which was characterized by high proportions of α-pinene (25.4%), germacrene D (20.2%), β-caryophyllene (10.8%), and δ-cadinene (6.4%). Acetylcholinesterase inhibitory activity was evaluated against the Ellman method, and the essential oil showed good inhibition against acetylcholinesterase (Percentage inhibition: 75.5%) assay.

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“…In view of the numerous studies that confirm the biological properties of essential oils and propose different applications for them, research into their toxicological and pharmacological characterization is necessary, in order to protect population health, in addition to the scientific proof of the therapeutic efficiency of these products …”

Section: Introductionmentioning

confidence: 99%

Toxicological Aspects of the Essential Oil from Cinnamodendron dinisii

Andrade

Cardoso

Prete

et al. 2018

Chemistry & Biodiversity

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The objective of this study was to determine cytotoxic activity, hemolytic activity, and to evaluate the ability of the essential oil from Cinnamodendron dinisii to induce DNA fragmentation of human lymphocytes. The essential oil was obtained by hydrodistillation. Cytotoxic activity was determined by the MTT method. Hemolytic activity was evaluated by spectrophotometric quantification of hemoglobin released by erythrocytes. Damage to lymphocyte DNA molecules was assessed by the Comet assay. The essential oil under study showed high cytotoxic activity on Vero cells (CC = 35.72 μg/mL) and induced hemolysis in both hematocrits, besides leading to the oxidation of hemoglobin released. The genotoxic activity of C. dinisii essential oil was also observed, which induced concentration-dependent DNA fragmentation of human lymphocytes and, at 50 μL/mL, it was more active than the positive control. The essential oil from C. dinisii has a toxic action, suggesting a special attention in the application of this oil to health-promoting activities; however, among its components, there are molecules with potential for future application in anticancer therapies.

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Essential oil from fruit of Xylopia langsdorffiana: antitumour activity and toxicity

Abstract: EOX showed in vitro and in vivo antitumour activity and low toxicity, which warrants further pharmacological studies.

Cited by 15 publications

References 35 publications

Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Chemical composition and acetylcholinesterase inhibition of the essential oil of Cyathocalyx pruniferus (Maingay ex Hook.f. & Thomson) J.Sinclair

Toxicological Aspects of the Essential Oil from Cinnamodendron dinisii

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