Essential oil nebulization in mild COVID-19(EONCO): Early phase exploratory clinical trial

Rathod, Ramya; Mohindra, Ritin; Vijayakumar, Akshay; Soni, Roop Kishor; Kaur, Ramandeep; Kumar, Ankit; Hegde, Naveen; Anand, Aishwarya; Sharma, Swati; Suri, Vikas; Goyal, Kapil; Ghosh, Arnab; Bhalla, Ashish; Gamad, Nanda; Singh, Amritpal; Patil, Amol

doi:10.1016/j.jaim.2022.100626

Cited by 6 publications

(17 citation statements)

References 16 publications

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“…Essential oils extracted from Thymus vulgaris , Citrus sinensis , Eugenia caryophyllus , and Boswellia carterii were able to assist faster fatigue resolution post-COVID-19, evidenced by a randomized, double-blinded, and placebo-controlled clinical trial [ 46 ]. Inhalation of nebulized mixture of several essential oils was found to reduced anosmia and dysgeusia in COVID-19 patients, but no effects were observed in terms of the viral clearance [ 47 ]. In another clinical trial, gargling povidone-iodine mixed with essential oils was found efficacious to shorten the period for viral clearance [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 pandemic sheds a new research spotlight on antiviral potential of essential oils – A bibliometric study

Ginting

Chiari

Duta

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

COVID-19 pandemic sheds a new research spotlight on antiviral potential of essential oils – A bibliometric study

Ginting

Chiari

Duta

et al. 2023

Heliyon

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“…Review articles have suggested that essential oils could also be used in managing COVID-19 disease [13,14]. Several clinical studies have been performed to test the efficacy of essential oils in improving COVID-19-related symptoms [15][16][17]. Unfortunately, previously published systematic reviews only covered computational or preclinical studies [18,19].…”

Section: Short Communicationmentioning

confidence: 99%

“…A total of 344 participants were included. Except for Dutt et al [15] and Khairiah et al [20], the other 2 studies included a placebo-controlled group [16,17]. The four studies used mixtures of essential oils as an adjunct therapy for symptomatic COVID-19 [15,17] or post-COVID-19 [16].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Except for Dutt et al [15] and Khairiah et al [20], the other 2 studies included a placebo-controlled group [16,17]. The four studies used mixtures of essential oils as an adjunct therapy for symptomatic COVID-19 [15,17] or post-COVID-19 [16]. Details of the characteristics of the included studies are presented in Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Essential oils were reported to reduce both symptoms of COVID-19 disease [15,17,20] and sequelae [16]. The administration of essential oils as adjuvant could was observed to be more beneficial for mild COVID-19 as compared to moderate severity [15,17]. Improvement in anosmia and dysgeusia was particularly observed in two study [17,20].…”

Section: Efficacy Of Essential Oil In Managing Covid-19mentioning

confidence: 99%

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Essential oils for COVID-19 management: A systematic review of randomized controlled trials

Duta,

Rizki,

Purnama

et al. 2023

Narra X

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Essential oils can be a beneficial adjuvant therapy in managing coronavirus disease 2019 (COVID-19). This systematic review aims to evaluate the efficacy of essential oils in ameliorative COVID-19-related symptoms. Published studies reporting the efficacy of essential oils as adjuvant therapy for COVID-19 were screened on Scillit, Scopus, SciFinder, and PubMed (December 7th, 2022). Inclusion criteria include the randomized controlled trials (RCTs) participated by those diagnosed with COVID-19 and treated with essential oils as adjuvant therapy. Quality assessment was carried out using Cochrane ‘risk-of-bias’ 2.0 tool. A total of 2112 records were retrieved from the initial screening, which was reduced to four publications (n=344 individuals). The foregoing studies reported that essential oils could improve the recovery rate, alleviate post-COVID-19 fatigue, and prevent disease progression. Regarding their potential antiviral activity, better designed studies are needed. In conclusion, essential oils as adjuvant therapy are beneficial in ameliorating mild COVID-19 symptoms.

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Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats

Sharma,

Taneja

et al. 2023

Journal of Complementary and Integrative Medicine

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Objectives The hepatoprotective properties of scopoletin have been explored in carbon tetrachloride (CCl4) induced liver injury but not in drug-induced liver injury (DILI) scenarios. Only N-acetyl-cysteine (NAC) has proven efficacy in DILI treatment. Accordingly, we conducted a study to assess the hepatoprotective action of scopoletin in the anti-tubercular treatment (ATT)-DILI model in Wistar rats, if any. Methods A total of 36 rats were evaluated, with six in each group. A 36-day ATT at 100 mg/kg dose for isoniazid, 300 mg/kg for rifampicin and 700 mg/kg for pyrazinamide were fed to induce hepatotoxicity in rats. Group I and II–VI received normal saline and ATT, respectively. Oral scopoletin (1,5 and 10 mg/kg) and NAC 150 mg/kg were administered in groups III, IV, V and VI, respectively, once daily for the last 15 days of the experiment. LFT monitoring was performed at baseline, days 21, 28, and 36. Rats were sacrificed for the histopathology examination. Results Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin levels were significantly increased in group II (receiving ATT) compared to normal control on day 28 and day 36 (p<0.05). All three doses of scopoletin and NAC groups led to the resolution of AST, ALT, ALP, and bilirubin changes induced by ATT medications effect beginning by day 28 and persisting on day 36 (p<0.01). An insignificant effect was observed on albumin and total protein levels. The effect was confirmed with antioxidants and histopathology analysis. Conclusions The study confirms the hepatoprotective efficacy of scopoletin in a more robust commonly encountered liver injury etiology.

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Essential oil nebulization in mild COVID-19(EONCO): Early phase exploratory clinical trial

Cited by 6 publications

References 16 publications

COVID-19 pandemic sheds a new research spotlight on antiviral potential of essential oils – A bibliometric study

COVID-19 pandemic sheds a new research spotlight on antiviral potential of essential oils – A bibliometric study

Essential oils for COVID-19 management: A systematic review of randomized controlled trials

Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats

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