Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea

Evangelista, Giovanni L.; Coelho‐de‐Souza, Andrelina Noronha; Santos, Cláudia Ferreira; Leal-Cardoso, José Henrique; Lopes, Érika Augusta Batista; Santos, Márcio Vasconcelos dos; Lahlou, Saad; Magalhães, Pedro J.C.

doi:10.1016/j.jep.2006.08.028

Cited by 20 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hexane CE from Pterodon emarginatus demonstrated anti-inflammatory activity, confirming the popular use of this species (Carvalho et al, 1999). Other species of the genus Pterodon were also available for different biological activities as larvicidal activity, antinociceptive, and inhibition of the contraction of smooth muscle of mice (Duarte et al, 1996;Coelho et al, 2005;Evangelista et al, 2007;Omena et al, 2007).…”

Section: Resultsmentioning

confidence: 65%

Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid

Toledo

Britta

Ceole

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 65%

Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid

Toledo

Britta

Ceole

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…The same authors elucidated the structure of taxifolin (dihydroquercetin), the most com- Table III. 4-methoxybenzoic acid (p-anisic acid) and triterpenes (lupeol and betulin) were isolated from the heartwood of P. polygalaeflorus (Marques et al, 1998). Sesquiterpenic essential oils were obtained from fruits and demonstrated to contain trans-b-caryophyllene (20.6%) followed by spathulenol (16.6%), a-capaene (10.4%), g-muurolene (8.1%), b-elemene, a-humulene, alloaromadendrene, bicyclogermacrene, d-cadinene, a-cubenene, g-cadinene, b-gurjunene, aromadendrene, germacrene D, a-calacorene, d-elemene, and a-gurjunene (Campos et al,1994;Evangelista et al, 2007).…”

Section: Chemistrymentioning

confidence: 99%

Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Hansen

Haraguchi

Alonso

2010

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.Uniterms: Sucupira. Pterodon/phytochemistry. Pterodon/pharmacognosy. Diterpenes/biological activity. Isoflavones/biological activity. Medicinal plants.As plantas do gênero Pterodon (Fabaceae/Leguminosae), conhecidas popularmente como "sucupira branca" ou "faveira", encontram-se distribuídas pela região central do Brasil e são frequentemente utilizadas na medicina popular por suas propriedades antirreumáticas, analgésicas e antiinflamatórias. Nos últimos anos, o interesse por estas plantas tem aumentado consideravelmente. Os efeitos biológicos dos diferentes fitoextratos e metabólitos puros têm sido investigados em vários modelos experimentais in vivo e in vitro. A literatura descreve flavonóides, triterpenos, esteróides e apenas um trabalho mostra estudos com proteínas isoladas do gênero. Esta revisão apresenta de maneira geral as investigações farmacológicas e fitoquímicas de Pterodon, mostrando os principais compostos já estudados, sua composição química, focando na relação entre estas moléculas e sua atividade biológica. Mais ainda, nós abrimos as portas para maior investigação, isolamento e caracterização de moléculas deste gênero de plantas.Unitermos: Sucupira. Pterodon/fitoquímica. Pterodon/farmacognosia. Diterpenos/atividade biológica. Isoflavonas/atividade biológica. Plantas medicinais.

show abstract

“…Pterodon polygalaeflorus Benth or Commilobium polygalaeflorus , popularly known as “sucupira branca” (white sucupira), is a tree common in the Brazilian Northeast region and abundant in Maranhão and Piauí states (15,16). It has great regional importance because of the widespread use of its shell and seeds in popular medicine as hydroalcoholic infusions for the treatment of chronic diarrhea (16), pharyngitis (15), and chronic pain and inflammation, such as in arthritis (17) and rheumatic diseases.…”

Section: Introductionmentioning

confidence: 99%

“…It has great regional importance because of the widespread use of its shell and seeds in popular medicine as hydroalcoholic infusions for the treatment of chronic diarrhea (16), pharyngitis (15), and chronic pain and inflammation, such as in arthritis (17) and rheumatic diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition and pharmacological effects of the essential oil of Pterodon polygalaeflorus Benth (EOPPgfl) seeds have been previously investigated (15,16). It has demonstrated antispasmodic action on tracheal smooth muscle by blockade of voltage-operated calcium channels (15) and on intestinal smooth muscle by myogenic mechanisms, mainly mediated through an intracellular mechanism (16).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice

Coelho‐de‐Souza

dos-Santos

Lopes-Filho

et al. 2018

Braz J Med Biol Res

View full text Add to dashboard Cite

Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon polygalaeflorus (EOPPgfl) and its acute toxic effects. The EEOPPgfl sample, which was extracted by steam distillation of the seeds, had a yield of 2.4% of the seeds weight and had, as major constituents, beta-elemene (48.19%), trans-caryophyllene (19.51%), and epi-bicyclosesquiphellandrene (12.24%). The EOPPgfl sample showed mild acute toxicity and its calculated median lethal dose (LD50) was 3.38 g/kg. EOPPgfl (20–60 mg/kg) showed antinociceptive activity as evidenced by several tests and inhibited writhing induced by acetic acid. The maximum effect was obtained with the 30 mg/kg dose and at 60 min after its administration. EOPPgfl also decreased formalin-induced nociception, as verified by the inhibition of the first and second phase of the formalin test. At 30 mg/kg, EOPPgfl also decreased thermally stimulated nociception. Nociception may be related to inflammatory and antiedematogenic activity and at doses ranging 10–100 mg/kg, EOPPgfl blocked dextran- and carrageenan-induced edema. The results demonstrated that EOPPgfl presented, at doses approximately 100 times smaller than LD50, an antinociceptive effect that probably was due to anti-inflammatory activities.

show abstract

Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea

Cited by 20 publications

References 28 publications

Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid

Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid

Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice

Contact Info

Product

Resources

About