Essential Oils from &amp;lt;i&amp;gt;Mentha viridis&amp;lt;/i&amp;gt; (L). L. and &amp;lt;i&amp;gt;Mentha pulegium&amp;lt;/i&amp;gt; L.: Cytogenotoxic Effects on Human Cells

Silva, Lucilene Fernandes; Cardoso, María das Graças; Prete, Paulo Sergio Castilho; Teixeira, Maria Luisa; Nelson, David Lee; Magalhães, Maísa Lamounier; Ferreira, Vanúzia Rodrigues Fernandes; Souza, Rafaela Vieira; Soares, Luana Isac; Marcussi, Silvana

doi:10.4236/ajps.2017.86097

Cited by 7 publications

(3 citation statements)

References 22 publications

(25 reference statements)

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“…Lipophilic molecules in essential oil can interact with the erythrocyte membrane to increase its fluidity. However, this interaction destroys the cell membrane, leading to the disordered inflow of ions and water, and eventually erythrocyte lysis [ 34 ]. A hemolysis test can determine how the components of the essential oil interact with human biological entities (red blood cells) at the cellular level; therefore, it can be used as one of the indicators of cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity and Antibacterial Mechanism of Lemon Verbena Essential Oil

Gao¹,

Liu²,

Li³

et al. 2023

Molecules

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The destructive effect and mode of action of lemon verbena essential oil on cells were investigated, taking the isolated Pseudosciaena D4 as the research object. The extracellular absorbance of the Pseudosciaena D4 increased at OD260 and OD280 after being treated with lemon verbena essential oil, which destroyed the integrity of Pseudosciaena D4 cells, showing a significant effect on preventing biomembrane formation and destroying the formed biomembrane. With an increased concentration of lemon verbena essential oil, extracellular polysaccharide showed a significant decrease in content and a significant increase in inhibition rate, indicating that the secretion of extracellular polysaccharide by Pseudosciaena D4 cells could be inhibited by lemon verbena essential oil during the process of biomembrane formation. Cell introcession and shrinkage appeared after the treatment with essential oil, and a transparent cavity was formed by the out-flowed cell content. Lemon verbena essential oil destroyed the cell wall, resulting in an enhanced permeability of the cell membrane and leakage of the contents, thereby causing cell death.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity and Antibacterial Mechanism of Lemon Verbena Essential Oil

Gao¹,

Liu²,

Li³

et al. 2023

Molecules

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“…After centrifugation at 4000 rpm for 5 min, the absorption of the resulting supernatant was determined at 548 nm by photometric monitoring against a blank sample. Control samples of 0% lysis (in buffer) and 100% lysis (in double-distilled water) were employed in all experiments (Bolard, 1986;Halla et al, 2013;Silva et al, 2017).…”

Section: Hemolytic Assaymentioning

confidence: 99%

“…According to some authors, the cytotoxicity of essential oils against red blood cells is due to their hydrophobic nature which is accentuated by the synergetic effect between their compounds (Sacchetti et al, 2005). Silva et al (2017) suggest that the constituents present in oils can interact with the components of the erythrocyte membrane, leading to destabilization of its structure and to a disordered influx of ions and water which leads to rupture of the membranes.…”

Section: Hemolytic Asssaymentioning

confidence: 99%

Polyphenols Content and Antimicrobial, Antioxidant and Hemolytic Activities of Essential Oils from Four Selected Medicinal Plants Growing in Algeria

et al. 2020

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The Saharan and steppe spontaneous plants are very characteristic because of their particular adaptation to the desert and extreme environment. Some species have pharmacological properties that give them a medicinal interest. The aim of the present work was to determine the polyphenol contents of essential oils obtained from four endemic plants growing in Algeria (Pituranthos scoparius, Myrtus nivellei, Rosmarinus officinalis and Mentha piperita), and study its biological activity, including antimicrobial, antioxidant, and hemolytic. The antimicrobial activity was evaluated by the microdilution method against twelve strains. The antioxidant activity was carried out by two methods (DPPH radical scavenging and reducing power). However, the hemolytic effect has been evaluated against the red blood cells. P. scoparius and M. piperita showed yields of essential oils higher than 1%. All the strains showed sensitivity against the essential oils tested with the exception of the C. albicans treated by R. officinalis essential oils. The most sensitive strain was C. albicans treated by P. scoparius essential oils by MIC of 0.0781 mg/mL, it was the same plant that shows the highest polyphenol content (14.78 ± 0.72 g GAE/g DS). The antioxidant activity by the DPPH method was greater for all essential oils tested by IC50 ranging from 0.69 ± 0.07 (R. officinalis) to 30.67 ± 2.12 mg/mL (M. nivellei). The R. officinalis essential oils reported more antioxidant power than the positive control (ascorbic acid). In reducing iron, it was the R. officinalis essential oils which were found to be the most active with an EC50 concentration of 9.67 ± 1.36 mg/mL. After 120 min incubation, minimal haemolysis (10%) was obtained with essential oils of R. officinalis at a concentration of 0.39 mg/mL. We conclude that P. scoparius essential oils showed the high content of polyphenols and R. officinalis essential oils reported more antioxidant power than the positive control (ascorbic acid).

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Biological Properties of Mentha viridis L. Essential Oil and Its Main Monoterpene Constituents

Omari,

Chamkhi,

Bakrim

et al. 2024

Chemistry & Biodiversity

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This research aimed to evaluate the antidiabetic, dermatoprotective, and antibacterial activities of Mentha viridis L. essential oil (MVEO) collected in the province of Ouezzane (Northwest Morocco). Gas chromatography‐mass spectrometry (GC‐MS) analysis revealed that the main constituents of MVEO were carvone (37.26%), 1,8‐cineole (11.82%), limonene (5.27%), α‐terpineol (4.16%), and β‐caryophyllene (4.04%). MVEO showed strong inhibitory effects on α‐amylase and α‐glucosidase activities, exceeding those of acarbose, but weak anti‐elastase activity. The main compounds, β‐caryophyllene (IC50 = 79.91 ± 2.24 and 62.08 ± 2.78 µg/mL) and limonene (IC50 = 90.73 ± 3.47 and 68.98 ± 1, 60 µg/mL), demonstrated the strongest inhibitory effects on both digestive enzymes (α‐glucosidase and α‐amylase, respectively). In silico investigations, using molecular docking, also showed the inhibitory potential of these bioactive compounds against the enzymes tested. In conclusion, MVEO, due to its main components such as limonene, 1,8‐cineole, β‐caryophyllene, carvone, and α‐terpineol, shows promising prospects for drug discovery and natural therapeutic applications.

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Essential Oils from <i>Mentha viridis</i> (L). L. and <i>Mentha pulegium</i> L.: Cytogenotoxic Effects on Human Cells

Cited by 7 publications

References 22 publications

Antibacterial Activity and Antibacterial Mechanism of Lemon Verbena Essential Oil

Antibacterial Activity and Antibacterial Mechanism of Lemon Verbena Essential Oil

Polyphenols Content and Antimicrobial, Antioxidant and Hemolytic Activities of Essential Oils from Four Selected Medicinal Plants Growing in Algeria

Biological Properties of Mentha viridis L. Essential Oil and Its Main Monoterpene Constituents

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