Essentielle Hyperlipämie und verminderte Fibrinolyse-Aktivität

Enhancement of the Fibrinolytic Activity by Venous Occlusion in Patients with Primary ‘Carbohydrate-Induced’ Hypertriglyceridemia

“…This diminished activator activity has been found earlier, using another assay method, in our laboratory [28]. Similar findings were made by Sw eet et al [31] and Blatny et al [6], whereas N itzberg et al [24] found the dilute whole blood lysis time to be similar in hypertriglyceridcmic and hypercholesteremic subjects and controls.…”

“…Apart from a direct effect of the increased plasma lipids on the arterial wall an inhibition of the fibrinolytic system in these patients has also to be taken into consideration as a cause of thrombus formation and probably also as a cause of atherogenesis. [24,28,31]. In previous papers concerning the fibrinolytic system in patients with PCH we have reported on an increase of fibrinogen, proactivator-plasminogen, slow-reacting antiplasmin and in the in hibitors of plasminogen activation by urokinase, whereas PA activity was found to be decreased [28,29,30], The inhibition of PA release from the vessel wall is supposed by H ow ell [18] to be one of the points, where the plasminogen activation sequence is blocked by lipids.…”

Die Bedeutung des Proaktivators im fibrinolytischen Fermentsystem

“…Die von uns erhobenen Befunde sprechen nicht fiir die u. a. von Hamberg (1966) postulierte Existenz eines weiteren Blutaktivators neben dem durch Streptokinase aus dem PA. gebildeten Aktivator. Die bei diesen Versuchen verwendeten Streptokinasemengen sind zur vollstandigen PA.-Aktivatorumwandlung sicher nicht ausreichend (Blix 1962, De Vreker 1965, Kline 1966, Spottl 1967.…”