Establishing the Link Between HBV Infection and Colorectal Adenoma

Patel, Brijesh; Lipka, Seth; Davis-Yadley, Ashley H.; Shen, Huafeng; Baronowsky, Alex; Silpe, Jeffrey; Pan, Qinshi; Mosdale, Josh; Viswanathan, Prakash; Abraham, Albin

doi:10.14309/00000434-201410002-00678

Cited by 10 publications

(16 citation statements)

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“…Two previous studies showed an association between HBV and colorectal adenoma. Patel et al reported that although the adenoma detection rate was higher in the hepatitis B group than in the non-hepatitis B group, the difference did not reach statistical significance (23.9%, n = 17/71 vs. 16.4%, n = 80/487; OR, 1.33; 95% CI, 0.70-2.51; p = 0.38) [13]. However, they demonstrated that there was a statistically significant association between HBV infection and the presence of distal colorectal adenomas (OR, 2.16; 95% CI, 1.06-4.43; p = 0.04) [13].…”

Section: Discussionmentioning

confidence: 97%

“…Patel et al reported that although the adenoma detection rate was higher in the hepatitis B group than in the non-hepatitis B group, the difference did not reach statistical significance (23.9%, n = 17/71 vs. 16.4%, n = 80/487; OR, 1.33; 95% CI, 0.70-2.51; p = 0.38) [13]. However, they demonstrated that there was a statistically significant association between HBV infection and the presence of distal colorectal adenomas (OR, 2.16; 95% CI, 1.06-4.43; p = 0.04) [13]. Recently, Kim et al showed that HBV infection (23.3%, n = 31/133 vs. 1.5%, n = 6/399; adjusted OR, 24.0; 95% CI, 9.40-61.1; p < 0.001) and HBV DNA in patients with HBV infection (HBV DNA (log); adjusted OR, 1.24; 95% CI, 1.03-1.49; p = 0.024) were independently associated with the risk of advanced adenoma [14].…”

Section: Discussionmentioning

confidence: 97%

“…However, studies on the association between HBV infection and colorectal adenoma, a precancerous lesion of CRC, are lacking. Thus far, two studies have investigated this topic; however, the sample size was too small to make a definitive conclusion [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Hepatitis B Virus Infection and Colorectal Neoplasia

Jung

Kim

Park

et al. 2019

JCM

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Background: Data about the association between hepatitis virus infection and colorectal neoplasia (CRN) are extremely limited. We examined the association between hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with the risk of CRN. Methods: A cross-sectional study was performed on asymptomatic examinees who underwent a colonoscopy and serologic testing for hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV Ab) between 2004 and 2015. Results: Of 155,674 participants who underwent serologic testing for HBsAg, 5476 (3.5%) were positive for HBsAg. The mean age of the study participants was 41.1 ± 9.1 years. The prevalence of CRN was higher in the HBsAg (+) than in HBsAg (-) participants (16.9% vs. 15.6%, p = 0.009). Even after adjusting for confounders, HBsAg positivity was correlated with an increased risk of CRN (odds ratio (OR), 1.10; 95% confidence interval (CI), 1.01-1.19; p = 0.025). Of 155,180 participants who underwent serologic testing for HCV Ab, only 240 (0.15%) were positive for HCV Ab. The prevalence of CRN was higher in HCV Ab (+) than in HCV Ab (-) participants (22.9% vs. 15.6%, p = 0.002). However, the association disappeared after adjusting for confounders (OR, 1.04; 95% CI, 0.72-1.50; p = 0.839). Conclusions: HBV infection was independently correlated with an increased risk of CRN.Our results indicate the possibility that HBV infection may contribute to colorectal carcinogenesis. Screening colonoscopy may have to be recommended more thoroughly for HBV-infected patients.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Correlation between Hepatitis B Virus Infection and Colorectal Neoplasia

Jung

Kim

Park

et al. 2019

JCM

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“…21 Moreover, there were some sporadic studies showing that HBV infection might be associated with gastric cancer, 12 nasopharyngeal carcinoma, 14 endometrial carcinoma 22 and distal colon adenoma. 23 Our study verified the modest but significant association with non-hepatocellular cancers, including NHL, pancreatic cancer, cholangiocarcinoma, gastric cancer and nasopharyngeal carcinoma, in a large cohort of Chinese patients. In addition, our study indicated that cervical cancer and brain cancer might be possibly HBV-related for the first time.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers

Xiao

Luo

et al. 2017

Intl Journal of Cancer

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Several non-hepatocellular cancers were linked with hepatitis B virus (HBV) infection. This study was aimed to quantify the potential associations between HBV infection and multiple non-hepatocellular cancers. Continuous cases, including 5,715 non-cancer and 40,963 cancer cases diagnosed from 2008 to 2014 in Sun Yat-sen University Cancer Center were analyzed. HBV DNA and hepatitis B core antigen (HBcAg) were examed in gastric cancer tissues by polymerase chain reaction and immunohistochemical staining. After adjusting for age, sex, year of diagnosis, smoking, drinking and family history of cancer, significant associations were found between serum HBsAg and frequently reported HBV-related non-hepatocellular cancers, including non-Hodgkin's lymphoma, cholangiocarcinoma and pancreatic cancer [adjusted odds ratio (AOR) and 95% confidence interval (CI): 1.89 (1.65-2.16)], as well as total other non-hepatocellular cancers [AOR and 95% CI: 1.12 (1.03-1.22)]. The median ages at diagnosis, all-cause death and cancer-specific death of serum HBsAg positive cancer patients were all significantly younger than those with serum HBsAg negative. HBV DNA was detected in 12.4% (34/275) gastric cancer tissues and HBcAg was most commonly detected in lymphocytes. This was the first report that HBV infection had a modest but significant nonspecific association with total non-hepatocellular cancers. Median age at diagnosis and death was significantly younger in serum HBsAg positive cancer patients. The underlying mechanism needs further investigation.

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“…In a recent retrospective chart review involving 487 patients undergoing screening or diagnostic colonoscopy, the adenoma detection rate was higher in HBV carriers than in the non-HBV population, although this observation did not reach statistical significance. However, the authors observed a positive association between HBV infection and the presence of distal colorectal adenoma [16]. In another study, Kim et al suggested that HBV infection was independently associated with the development of advanced colorectal adenoma [17].…”

Section: Introductionmentioning

confidence: 97%

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

Muo

et al. 2020

Viruses

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Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20–1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55–64, and 65–74 years were 1.63 (95% CI = 1.48–1.79), 1.24 (95% CI = 1.13–1.37), and 1.02 (95% = 0.92–1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.

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Establishing the Link Between HBV Infection and Colorectal Adenoma

Cited by 10 publications

References 0 publications

Correlation between Hepatitis B Virus Infection and Colorectal Neoplasia

Correlation between Hepatitis B Virus Infection and Colorectal Neoplasia

Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

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