2013
DOI: 10.1007/s10059-013-0117-7
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Establishment of a Bone-Specific col10a1:GFP Transgenic Zebrafish

Abstract: During skeletal development, both osteogenic and chondrogenic programs are initiated from multipotent mesenchymal cells, requiring a number of signaling molecules, transcription factors, and downstream effectors to orchestrate the sophisticated process. Col10a1, an important downstream effector gene, has been identified as a marker for maturing chondrocytes in higher vertebrates, such as mammals and birds. In zebrafish, this gene has been shown to be expressed in both osteoblasts and chondrocytes, but no study… Show more

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Cited by 35 publications
(20 citation statements)
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“…Subsequently, LHY was likely added during green plant evolution as complications from multi-cellularity arose. Indeed insights into early and diverse plant circadian systems already suggests wide conservation and evidence for expansion of clock gene families resulting from genome duplication events throughout evolution [30][31][32][33][34]. Therefore contributions from comprehensive lineage specific circadian systems will be valuable to understanding how the clock model has evolved into a complex network in plants.…”
Section: Interconnected Transcriptional Circuits In the Clock Networkmentioning
confidence: 99%
“…Subsequently, LHY was likely added during green plant evolution as complications from multi-cellularity arose. Indeed insights into early and diverse plant circadian systems already suggests wide conservation and evidence for expansion of clock gene families resulting from genome duplication events throughout evolution [30][31][32][33][34]. Therefore contributions from comprehensive lineage specific circadian systems will be valuable to understanding how the clock model has evolved into a complex network in plants.…”
Section: Interconnected Transcriptional Circuits In the Clock Networkmentioning
confidence: 99%
“…Mouse Col10a1 encodes the alpha chain of type X collagen that belongs to a short chain collagen, and functions only in hypertrophic chondrocytes during endochondral ossification [51]. col10a1a was shown to be expressed in both chondrocytes and osteoblasts in zebrafish and other fish such as medaka [26,52]. In this study, we provided evidence that Sp7 is able to bind to the Sp1 sites of the zebrafish col10a1a promoter to activate col10a1a expression in a way similar to how Sp7 to regulate col1a1 and col1a2 [17,53].…”
Section: Discussionmentioning
confidence: 99%
“…S3). Runx2 as a transcription factor also can bind to RBS (Runx2-binding site) to regulate expression of col1a1, col1a2 and col10a1, and be a critical transcription factor for early chondrogenesis and osteoblast differentiation [52,[54][55][56][57][58]. Because of no altered expression of runx2a and runx2b in the sp7À/À (Fig.…”
Section: Discussionmentioning
confidence: 99%
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“…In zebrafish, panx3 expression was first detected in the cl, which is formed via intramembranous ossification at 48 hpf and maintained until 72 hpf, but this expression disappeared when the cl was mineralized, as assessed via alizarin red staining at 96 hpf (Fig. 2) (33). Similarly, panx3 expression in the intramembranous op was shown to be restricted to the nonmineralized region (Fig.…”
Section: Discussionmentioning
confidence: 99%