Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel

Lee, DaeYong; Choe, Ki Baek; Jeong, YongJun; Yoo, Jisang; Lee, Sungmun; Park, Ji-Ho; Kim, Pilhan; Kim, Yeu Chun

doi:10.1039/c4ra16656f

Cited by 39 publications

(42 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All of the other chemicals and reagents were of analytical grade. Lys(Z) (5.00 g, 17.85 mmol) was reacted with triphosgen (2.12 g, 7.15 mmol) suspended in THF (65 mL) at 50 C for 3 h under nitrogen purging [33]. Lys(Z)-NCA was precipitated with the excess cold n-hexane and the product was purified by repeated filtration.…”

Section: Methodsmentioning

confidence: 99%

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

et al. 2015

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

et al. 2015

View full text Add to dashboard Cite

“…On the other hand, studies performed in diabetic animal models have demonstrated that NGs based on polymers functionalized with PBA derivatives can release insulin in a controlled fashion according to glucose blood levels. Actually, after administration, NGs can maintain low glucose levels for longer compared with free insulin [152,153] (Figure 9).…”

Section: Biotechnological Uses Of Nanogelsmentioning

confidence: 99%

“…Schematic picture of glucose sensitivity of a double-layered nanogel composed by glycol chitosan/sodium alginate(SA)-poly( l -glutmate- co - N -3- l -glutamylphenylboronic acid) (PGGA) encapsulating insulin and releasing it in the presence of glucose by complexation between PBA derivative and glucose. (Reprinted with permission from reference [152]. Copyright 2015 RSC).…”

Section: Figurementioning

confidence: 99%

The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy

Vicario‐de‐la‐Torre¹,

Forcada

2017

Gels

View full text Add to dashboard Cite

Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs are cross-linked nanoparticles (NPs), composed of polymers, natural, synthetic, or a combination thereof that can swell by absorption (uptake) of large amounts of solvent, but not dissolve due to the constituent structure of the polymeric network. NGs can undergo change from a polymeric solution (swell form) to a hard particle (collapsed form) in response to (i) physical stimuli such as temperature, ionic strength, magnetic or electric fields; (ii) chemical stimuli such as pH, ions, specific molecules or (iii) biochemical stimuli such as enzymatic substrates or affinity ligands. The interest in NGs comes from their multi-stimuli nature involving reversible phase transitions in response to changes in the external media in a faster way than macroscopic gels or hydrogels due to their nanometric size. NGs have a porous structure able to encapsulate small molecules such as drugs and genes, then releasing them by changing their volume when external stimuli are applied.

show abstract

“…The double-layered nanogel of GC/SA-PGGA was prepared by an isotropic gelation method and electrostatic interaction between GC and SA-PGGA [68]. The glucose-induced insulin release profiles at diabetic glucose levels in vitro were demonstrated.…”

Section: Glucose-triggered Drug Deliverymentioning

confidence: 99%

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Huang

Liu

et al. 2017

Materials

View full text Add to dashboard Cite

In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.

show abstract

Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel

Abstract: Glucose-responsive glycol chitosan/sodium alginate-poly(l-glutmate-co-N-3-l-glutamylphenylboronic acid) double-layered nanogel is a promising platform for controlled insulin release systems, achieving glucose-triggered insulin release at diabetic glucose levels in vivo.

Cited by 39 publications

References 29 publications

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Contact Info

Product

Resources

About