Establishment of hematological reference intervals for healthy adults in Asmara

Siraj, Nejat; Issac, John; Anwar, Mohammed; Mehari, Yohannes; Russom, Shushan; Kahsay, Semere; Frezghi, Haben

doi:10.1186/s13104-018-3142-y

Cited by 17 publications

(20 citation statements)

References 13 publications

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“…In addition to that, menstrual period may lead down women RBC count. Our findings comply with several studies [10,12,[20][21][22][23][24]. Conversely, females had higher levels of MCV and MCH and involved those of 6-15 years of age.…”

Section: Discussionsupporting

confidence: 93%

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Béavogui

Touré

Camara

et al. 2020

BioMed Research International

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Guinea’s reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5th and 97.5th percentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHC p≤0.001, Platelets p≤0.001, monocytes p=0.0305, eosinophils p=0.0225; for biochemical parameters: Aspartate aminotransferase AST p≤0.001, Alanine Aminotransferase ALT p≤0.001, creatinine p≤0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable.

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Section: Discussionsupporting

confidence: 93%

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Béavogui

Touré

Camara

et al. 2020

BioMed Research International

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“…whereas the females scored a mean of 32.4g/dL RBCs [9]. One can notice that apart from the MCHC, all the current results are lower than the population-based study.…”

Section: Discussioncontrasting

confidence: 82%

Hematological parameters in apparently Healthy Eritrean blood donors at the National Blood Transfusion Center, Asmara, Eritrea.

Abdon

Adgoy

Berhane

et al. 2020

SJMS

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Introduction: This study was done to measure the Hemoglobin levels, Red Blood Cells count, and Red Blood cell parameters: MCV, MCH, MCHC, RDW, and Hematocrit of the apparently healthy blood donors attending the National Blood Bank of Eritrea. Methods: Blood samples were collected from the peripheral veins into the (EDTA)-tube and examined for Red Blood Cell count (RBC), hemoglobin (Hb), Hematocrit (%), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), and red cell distribution width (RDW), analyzed and measured by automated blood analyzer. Results: The mean Hemoglobin level was 14.428±1.485 g/dl, RBCs count was 4.744±0.482×1012/L, HCT was 41.929 ±3.75%, Red cell distribution width (RDW) mean was 13.571±0.744%, MCV was 88.582± 4.0558 Fimtoliter, MCH was 30.470±2.188 picogram, and MCHC was a mean of 34.393±1.347g/dl. The difference between males and females in MCV and MCHC was significant in favor of female donors. And a weak positive correlation had been found between the weight and age of donors and the Hemoglobin level. All the measured values were found to be within the global referenced ranges. Conclusion: Hemoglobin, RBCs count and RBCs indices of apparently healthy Eritrean blood donors were measured for reference, and all values were found within normal reference ranges.

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“…This study found the RIs for RBC, Hb, HCT, MCV and MCH to be higher in males compared to females whereas WBC and platelet counts were higher in females compared to males as consistent with previous reports in other African countries [ 8 , 18 – 22 ]. The differences in RIs based on sex may be linked to the effect of menstruation and its associated increased demand for iron, differences in androgen hormones (testosterone and oestrogen) and the extent to which erythropoiesis and megakaryopoiesis are regulated in males and females [ 21 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Reference intervals for selected haematological and biochemical parameters among apparently healthy adults in different eco-geographical zones in Ghana

et al. 2021

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Background Due to the influence of gender, race/genetics, age, lifestyle habits and geography on the references intervals (RIs), the Clinical and Laboratory Standards Institute (CLSI) recommends the determination of population-specific RIs. Ghana continues to depend on pre-established RIs from other countries which poses the risk of misdiagnoses and wrong treatment. This study presents the haemato-biochemical RIs from four eco-geographical zones in Ghana. Methods In this population-based cross-sectional study, a total of 1227 randomly selected healthy voluntary blood donors from the four eco-geographic zones (Coastal Savannah, Rain Forest, Savannah and Transitional) were enrolled and screened. Based on the CLSI Guidance Document C28A2992, the data of eligible participants were used to non-parametrically determine the RIs for the haemato-biochemical parameters at the 2.5th and 97.5th percentiles. Comparison of analytes by gender was done by Wilcoxon rank sum test and eco-geographic differences were assessed using the Kruskal-Wallis with the Dunn post hoc multiple comparison tests. Results There were statistically significant differences in most of the haematological parameters (RBC, Hb, HCT, MCV, PLT, WBC; p-values <0.0001 and MCH; p-value = 0.007), and biochemical analytes (Urea, Cr, Trig, HDL-C, AST, ALT, ALP, GGT, BID, BIT, Prot-T and Albumin; p-values <0.0001) based on gender. Significant inter eco-geographic (intra-population) variations and substantial differences between the established RI and the RIs accompanying the analyzers used were also observed. Conclusion This study reports significant inter-sex and inter-geographical differences in haemato-biochemical RIs in Ghana as well as differences in RIs with both the RIs accompanying the analyzers and those of other countries. Determining RIs representative of populations and including them in the report systems of laboratories to ensure effective and efficient healthcare service delivery is thus recommended.

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Establishment of hematological reference intervals for healthy adults in Asmara

Cited by 17 publications

References 13 publications

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Hematological parameters in apparently Healthy Eritrean blood donors at the National Blood Transfusion Center, Asmara, Eritrea.

Reference intervals for selected haematological and biochemical parameters among apparently healthy adults in different eco-geographical zones in Ghana

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