Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

Yadav, Dharamveer; Mishra, Sandhya; Gupta, Monika; Park, John; Sharma, Praveen

doi:10.1007/s12291-012-0281-0

Cited by 15 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies from different geographical locations of India have established reference intervals for certain biochemical parameters and also identified significant changes in liver markers and lipid levels in healthy Indian population [16][17][18][19][20][21]. Furthermore, we have documented that the renal and cell integration markers like creatinine, AST and GGT were lower in females than males as supported by previous studies done elsewhere [22,23].…”

Section: Discussionsupporting

confidence: 84%

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Sairam¹,

Domalapalli

Maruthamuthu

et al. 2013

Ind J Clin Biochem

View full text Add to dashboard Cite

Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3-17 g/dL; Females: 9.9-14.3 g/dL), platelet count (Males: 1.3-3.8; Females: 1.3-4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2-22; Females: 4-55 mm/h), serum uric acid in males: 3.5-8.2 mg/dL, gamma glutamyl transferase (Males: 13-61 U/L), fasting blood glucose (Males: 78-110 mg/dL), total cholesterol (Males: 115-254 mg/dL), low density lipoprotein (Males: 60-176 mg/dL) and triglycerides (Males: 55-267 mg/dL, Females: 52-207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies.

show abstract

Section: Discussionsupporting

confidence: 84%

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Sairam¹,

Domalapalli

Maruthamuthu

et al. 2013

Ind J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…The population-based reference interval is the most widely used tool for interpretation of individual patient laboratory test results [1]. Reference values are used in interpreting results of laboratory measurements, clinical trials screening and as the basis of safety monitoring for trial participants [2].…”

Section: Introductionmentioning

confidence: 99%

Reference Interval for Renal Profile parameters in North Indian Population from Rajasthan

Yadav¹,

Gupta²,

Mishra³

et al. 2015

Int J of Adv in Sci Res

Self Cite

View full text Add to dashboard Cite

Objective: Reference intervals are an essential part of laboratory medicine. Current study was planned to evaluate renal parameters in the healthy defined group of individuals which would serve as reference values of renal parameters for the North Indian population from Rajasthan. Design & Methods: Present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Fasting samples were analyzed for Urea, Creatinine, Uric Acid, Sodium, Potassium and Chloride. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0. Result: RI for Urea, Creatinine and uric acid were lower in female (16-42mg/dl, 0.6-1.2mg/dl, 2.4-6.8mg/dl) as compared to male (17.00-44.35mg/dl, 0.7-1.5mg/dl, 2.8-7.2mg/dl). There was a progressive increase in urea, uric acid and Creatinine with increase in age. Though no appreciable differences could be observed in respect to most of renal parameters in rural versus urban, a wider range for uric acid was observed in urban population (2.50-7.20mg/dl). Except for Na + , K + and Cl -, rest of parameters i.e. urea, creatinine, uric acid were higher range in obese as compared to non obese (17-45 Vs 17-44, 0.66-1.5 Vs 0.60-1.40, 2.5-7.4 Vs 2.5-7.0). Uric acid level was also found to be higher in non vegetarian population (2.6-7.5mg/dl). Conclusion: Findings of this study provide sex, age, BMI, habitat and diet specific renal function reference values to be used for North Indian population.

show abstract

“…Whether, the difference is attributable to the exclusion of all alcoholics irrespective of intake volume need further systematic exploration in future studies. Table 3 shows the comparison between Indian studies on upper limit of normal for ALT [8][9][10][11]. Variation in the methods (mean ± SD, median with range, median with inter-quartile range and percentiles) adopted by Indian studies to describe and analyze ALT, makes comparison of ALT in present study with other studies in the region less comprehensive.…”

Section: Discussionmentioning

confidence: 99%

Estimation of Upper Limit of Normal for Serum Alanine Transaminase in Healthy South Indian Population

Mohan

Sundar²,

Bhaskar

et al. 2016

Ind J Clin Biochem

View full text Add to dashboard Cite

Alanine aminotransferase (ALT) is the most common and cost effective screening test for asymptomatic liver disease. There is paucity of data on normal ALT among healthy individuals in India. An observational cross sectional study was conducted from January to July 2013 to estimate the upper limit of normal for ALT in healthy south Indian population. Adults undergoing voluntary or pre-employment health screening were included. Those with current and past alcoholism or smoking, acute illness or hospitalization during preceding 12 months, non-steroidal anti-inflammatory or over the counter medication use within a month, current or past intake of herbal medications, any chronic medical illness, abnormal body mass index (BMI), fatty liver in ultrasound, abnormality in haemoglobin, platelet count, blood sugar, creatinine, lipid profile and thyroid function test and positive serology (Hepatitis B, C or HIV) were excluded. A total of 2600 subjects were screened. 344 were included for analysis. Mean age was 35 years in men and 34.83 years in women, with a mean BMI of 22.2 kg/m in men and 21.8 kg/m in women. The mean ALT in men and women were 21.87 ± 2.9 (97.5th percentile 28 U/L) and 19.35 ± 3.3 (97.5th percentile 24 U/L) respectively. In conclusion, mean and upper limit of ALT (97.5th percentile) in south Indian men was 21.87 and 28 IU/L and women were 19.35 and 24 IU/L respectively. There is a need to re-consider ALT levels in our population for better detection of individuals at risk for liver disease.

show abstract

Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

Cited by 15 publications

References 9 publications

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Reference Interval for Renal Profile parameters in North Indian Population from Rajasthan

Estimation of Upper Limit of Normal for Serum Alanine Transaminase in Healthy South Indian Population

Contact Info

Product

Resources

About