Establishment of T-helper Type 2 Clone-induced Eosinophilia in Mouse Conjunctiva

Hamada, Muneo; Sawa, Kenjiro; Nakata, Katsuhiko

doi:10.1006/exer.1999.0677

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…As we previously reported in this model, there was a strong infiltration of inflammatory cells into the conjunctiva by the movement of activated Th2 cells, and most of the inflammatory cells were eosinophils. 18 Therefore, FIGURE 2. Changes in the corneal fluorescein staining score after D10 injection in mice.…”

Section: Discussionmentioning

confidence: 93%

“…18 In this model, coinjection of the Th2 clone and conalbumin, its specific antigen, into the conjunctiva increased the number of eosinophils infiltrating the conjunctiva after 24 hours, which was inhibited by anti-IL-5 monoclonal antibody treatment. In the present study, we used this model to examine the influence of activated Th2 cells and infiltrated eosinophils on the corneal epithelium.…”

Section: Introductionmentioning

confidence: 98%

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Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Shii

Oda

Nakamura

2010

Cornea

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Shii

Oda

Nakamura

2010

Cornea

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“…Cyclosporine A eye drops may therefore inhibit eosinophil migration via the suppression of T-cells in type I allergic conjunctiva. Hamada et al reported that the injection of D10 cells, a Th2 clone activated by the specific antigen conalbumin, into AKR/J mice conjunctiva induced eosinophil migration [20]. This system was used to evaluate the effects of cyclosporine A eye drops on Th2 cells.…”

Section: Involvement Of Inflammatory Cells In Vkc and The Therapeuticmentioning

confidence: 99%

Therapeutic Effects and Mechanisms of Action of Cyclosporine A Ophthalmic Solution in the Treatment of Vernal Keratoconjunctivitis

Shii¹,

Fukushima

2007

CPA

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Cyclosporine A ophthalmic solutions have recently emerged as an effective treatment for vernal keratoconjunctivitis (VKC). Cyclosporine A is known to have multiple inhibitory effects on T-cells, and allergic conjunctivitis models have shown that cyclosporine A eye drops can effectively inhibit T-cell-mediated eosinophil and neutrophil migration. Inhibitory effects of cyclosporine A on other inflammatory cells have also been documented. Release of histamine and cytokines from mast cells was shown to be inhibited by cyclosporine A and cyclosporine A eye drops were able to inhibit histamine release and migration of inflammatory cells in allergic conjunctivitis models mediated by mast cells. Cyclosporine A has also been reported to induce eosinophil apoptosis and block the ability of these cells to release eosinophil cationic protein (ECP). In neutrophils, cyclosporine A can inhibit the release of myeloperoxidase (MPO) and reactive oxygen species. In fibroblasts, cyclosporine A has been demonstrated to inhibit proliferation and pro-collagen production. In vitro, cyclosporine A has variable effects on inflammatory cells, underscoring the need for further experimentation to elucidate the full range of its cytologic effects and their relation to therapeutic outcome. The diverse inhibitory effects of cyclosporine A on inflammatory cells clearly underlie the ability of this drug to alleviate the symptoms of VKC.

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Cyclosporin-A-2%-Augentropfen in der Therapie der Keratoconjunctivitis atopica und vernalis

Tomida

Schlote²,

Bräuning³

et al. 2002

Der Ophthalmologe

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Establishment of T-helper Type 2 Clone-induced Eosinophilia in Mouse Conjunctiva

Cited by 4 publications

References 25 publications

Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Therapeutic Effects and Mechanisms of Action of Cyclosporine A Ophthalmic Solution in the Treatment of Vernal Keratoconjunctivitis

Cyclosporin-A-2%-Augentropfen in der Therapie der Keratoconjunctivitis atopica und vernalis

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