Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia

Ryan, Peter; Turley, Andrew P.; Wilson, Geoff; Hurst, Tim; Retzki, Kate; Brown-Kenyon, Jack; Hodgson, Lauren; Kenny, Nichola; Cook, Helen; Montgomery, Brian L.; Paton, Christopher J.; Ritchie, Scott A.; Hoffmann, Ary A.; Jewell, Nicholas P.; Tanamas, Stephanie K.; Anders, Katherine L.; Simmons, Cameron P.; O’Neill, Scott L.

doi:10.12688/gatesopenres.13061.2

Cited by 184 publications

(161 citation statements)

References 32 publications

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“…Releases of Aedes aegypti mosquitoes carrying Wolbachia to block the transmission of dengue virus (DENV) are currently being deployed as a novel dengue control strategy in a number of countries, with very encouraging results 1 , 2 . In their paper entitled “Variation in Wolbachia effects on Aedes mosquitoes as a determinant of invasiveness and vectorial capacity”, King et al 3 used DENV infection and transmission modelling to reinterpret experimental data from two previous studies 4 , 5 .…”

mentioning

confidence: 99%

Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

et al. 2020

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confidence: 99%

Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

et al. 2020

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“…Furthermore, recent field trials demonstrated that deployment of the wMel strain into local Ae. aegypti populations can result in a reduction of local dengue transmission [16,17]. Despite the effectiveness of Wolbachia's viral protection, the mechanism(s) that underlies the ability of Wolbachia to control the virus replication is not well understood.…”

Section: Discussionmentioning

confidence: 99%

The RNAi Pathway Is Important to Control Mayaro Virus Infection in Aedes aegypti but not for Wolbachia-Mediated Protection

Sucupira¹,

Ferreira²,

Leite

et al. 2020

Viruses

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Mayaro virus (MAYV), a sylvatic arbovirus belonging to the Togaviridae family and Alphavirus genus, is responsible for an increasing number of outbreaks in several countries of Central and South America. Despite Haemagogus janthinomys being identified as the main vector of MAYV, laboratory studies have already demonstrated the competence of Aedes aegypti to transmit MAYV. It has also been demonstrated that the Wolbachia wMel strain is able to impair the replication and transmission of MAYV in Ae. aegypti. In Ae. aegypti, the small interfering RNA (siRNA) pathway is an important antiviral mechanism; however, it remains unclear whether siRNA pathway acts against MAYV infection in Ae. aegypti. The main objective of this study was to determine the contribution of the siRNA pathway in the control of MAYV infection. Thus, we silenced the expression of AGO2, an essential component of the siRNA pathway, by injecting dsRNA-targeting AGO2 (dsAGO2). Our results showed that AGO2 is required to control MAYV replication upon oral infection in Wolbachia-free Ae. aegypti. On the other hand, we found that Wolbachia-induced resistance to MAYV in Ae. aegypti is independent of the siRNA pathway. Our study brought new information regarding the mechanism of viral protection, as well as on Wolbachia mediated interference.

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“…aegypti populations have been started in 2017 seem promising. [ 111 , 112 ]. According to the World Mosquito Program (WMP) studies conducted in Indonesia over a period of 3 years showed that compared to untreated areas, there is a 77% reduction in the incidence of virologically confirmed Dengue fever in Wolbachia -treated areas of Yogyakarta, Indonesia (Clinical Trial No.…”

Section: Current Strategies Against Chikvmentioning

confidence: 99%

Prophylactic strategies to control chikungunya virus infection

2021

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Chikungunya virus (CHIKV) is a (re)emerging arbovirus and the causative agent of chikungunya fever. In recent years, CHIKV was responsible for a series of outbreaks, some of which had serious economic and public health impacts in the affected regions. So far, no CHIKV-specific antiviral therapy or vaccine has been approved. This review gives a brief summary on CHIKV epidemiology, spread, infection and diagnosis. It furthermore deals with the strategies against emerging diseases, drug development and the possibilities of testing antivirals against CHIKV in vitro and in vivo. With our review, we hope to provide the latest information on CHIKV, disease manifestation, as well as on the current state of CHIKV vaccine development and post-exposure therapy.

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Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia

Abstract: The Mel strain of has been successfully

Cited by 184 publications

References 32 publications

Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

The RNAi Pathway Is Important to Control Mayaro Virus Infection in Aedes aegypti but not for Wolbachia-Mediated Protection

Prophylactic strategies to control chikungunya virus infection

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