Ester Derivatives from Tannase‐Treated Prunioside A and Their Antiinflammatory Activities.

Chen, Jun; Yoo, Myung-Ja; Lee, Woo-Yiel; Kwak, Kyung-Chell; Bae, Moon-Sung; Hwang, Woo-Taek; Son, Dong-Hwan; Chai, Kyu Yun

doi:10.1002/chin.200723179

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…Tannase also serves to enable the cleavage of poly phenolics, such as the dehydrodimer cross-links present in the cell wall of plants, which are necessary for plant cell wall digestibility [17], and in the determination of the structure of naturally occurring gallic acid esters [41]. A number of innovative applications of tannase have been reported, such as in the enhancement of antioxidant activity and in vitro inhibitory activity against the N-nitrosation of dimethylamine in green tea [29,30], in the production of derivatives from prunioside-A with anti-inflammatory activities [22], in the hydrolysis of epigallocatechin gallates [8], and in enzymatic treatment for the nutritive utilization of proteins and carbohydrates from peas [46]. Tannase has a potential use in the degradation of tannins present in the effluents of tanneries, the latter posing serious environmental concerns [48].…”

mentioning

confidence: 99%

Acidophilic Tannase from Marine Aspergillus awamori BTMFW032

Beena

Soorej²,

Elyas³

et al. 2010

J. Microbiol. Biotechnol.

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Aspergillus awamori BTMFW032, isolated from sea water, produced tannase as an extracellular enzyme under submerged culture conditions. Enzymes with a specific activity of 2,761.89 IU/mg protein, a final yield of 0.51%, and a purification fold of 6.32 were obtained after purification through to homogeneity, by ultrafiltration and gel filtration. SDS-PAGE analyses, under nonreducing and reducing conditions, yielded a single band of 230 kDa and 37.8 kDa, respectively, indicating the presence of six identical monomers. A pI of 4.4 and a carbohydrate content of 8.02% were observed in the enzyme. The optimal temperature was found to be 30 o C, although the enzyme was active in the range of 5-80 o C. Two pH optima, pH 2 and pH 8, were recorded, although the enzyme was instable at a pH of 8, but stable at a pH of 2.0 for 24 h. Methylgallate recorded maximal affinity, and K m and V max were recorded at 1.9× 10-3 M and 830 µmol/min, respectively. The impacts of a number of metal salts, solvents, surfactants, and other typical enzyme inhibitors on tannase activity were determined in order to establish the novel characteristics of the enzyme. The gene encoding tannase, isolated from A. awamori, was found to be 1.232 kb, and nucleic acid sequence analysis revealed an open reading frame consisting of 1,122 bp (374 amino acids) of one stretch in the-1 strand. In silico analyses of gene sequences, and a comparison with reported sequences of other species of Aspergillus, indicate that the acidophilic tannase from marine A. awamori differs from that of other reported species.

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confidence: 99%

Acidophilic Tannase from Marine Aspergillus awamori BTMFW032

Beena

Soorej²,

Elyas³

et al. 2010

J. Microbiol. Biotechnol.

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“…Although naturally occurring prunioside A from S. prunifolia var. simpliciflora roots showed no inhibitory effect, its derivatives have inhibitory effects on nitric oxide production in murine macrophagelike RAW 264.7 cells stimulated with LPS and interferon-γ and may be useful for the treatment of inflammatory diseases [ 97 , 98 , 99 , 100 ].…”

Section: Chemical Components and Biological Activity Of The Isolated Substancesmentioning

confidence: 99%

“…A new terpene glucoside—prunioside A ( 96 , Figure 2 )—has been isolated from a methanolic extract of S. prunifolia var. simpliciflora roots [ 97 , 100 ].…”

Section: Chemical Components and Biological Activity Of The Isolated Substancesmentioning

confidence: 99%

Phytoconstituents and Bioactivity of Plants of the Genus Spiraea L. (Rosaceae): A Review

Kostikova

Петрова

2021

IJMS

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The genus Spiraea L. belongs to the Rosaceae Juss. family and includes more than 100 species distributed in the temperate zone and subtropical zone of the Northern Hemisphere at the center of species diversity in East Asia. Representatives of the genus are known as ornamental plants with many forms and varieties, are widely used in conventional medicine, and have a high resource potential. This review provides information on the diversity of phenolic compounds (flavonoids, phenolcarboxylic acids, and lignans), terpenoids, alkaloids, steroids, and other classes of secondary metabolites in the species of Spiraea worldwide. The article also presents little-known and hard-to-find data published in Russian concerning Spiraea phytochemistry. The biological activities of extracts and their fractions and of individual compounds having different types of biological activity (e.g., antioxidant, antibacterial, anti-inflammatory, and antifungal) are discussed. Data about biotechnological research on representatives of the genus Spiraea are presented too. The analysis of the literature showed that further chemical and pharmacological studies on Spiraea plants are quite promising.

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“…조팝나무 뿌리에는 주로 urasolic acid, tormentic acid 등의 triterpenoid 계열, campesterol, β-sitosterol 등의 steroid계열 및 p-hydroxycinnamic acid 등 phenolic 화합물 등이 보고되어 있다 [10][11][12]. 조팝나무를 이용한 생리활성 연구는 뿌리 추출물을 이용한 항염증 활성과 조팝나 무 가지 추출물의 항암 및 신경세포 성장인자 분비촉진 활성이 보고되었으며 [13][14][15], 화합물로는 뿌리에서 분리된 prunioside A 의 항산화 및 항염증 활성이 보고되었다 [16,17] (Fig. 1).…”

Section: 서 론unclassified

Neuroprotective effects of phenolic compounds isolated from Spiraea prunifolia var. simpliciflora

Choi

Kim

et al. 2018

JABC

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The leaves of Spiraea prunifolia were extracted with 80% aqueous MeOH and the concentrates were partitioned into EtOAc, n-BuOH, and H 2 O fractions. The repeated SiO 2 or ODS column, and medium pressure liquid chromatographies for the n-BuOH fraction led to isolation of two phenolic glucosides. The chemical structures of these compounds were determined as isosalicin (1) and crenatin (2) based on spectroscopic analyses including Nuclear magnetic resonance and MS. Extracts were analyzed using UPLC-MS/MS providing a short analysis time within 5 min using MRM technique. The concentration of crenatin was higher as 9.53 mg/g and isosalicin was lower as 0.65 mg/g. Neuroprotective effects of these compounds against hydrogen peroxide (H 2 O 2)-induced neurotoxicity were evaluated. The results showed that exposure to H 2 O 2 induced morphological changes, cell death and neurotoxicity in SK-N-MC cells. However, pretreatment with crenatin resulted in inhibition of morphological change, reduction of loss of cell viability and attenuation of neuronal damage. These results suggested that neuroprotective effect of crenatin isolated from S. prunifolia can be a good candidate for the development of health beneficial foods which can ameliorate the degenerative neuronal disease caused by oxidative stress.

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Ester Derivatives from Tannase‐Treated Prunioside A and Their Antiinflammatory Activities.

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 5 publications

References 2 publications

Acidophilic Tannase from Marine Aspergillus awamori BTMFW032

Acidophilic Tannase from Marine Aspergillus awamori BTMFW032

Phytoconstituents and Bioactivity of Plants of the Genus Spiraea L. (Rosaceae): A Review

Neuroprotective effects of phenolic compounds isolated from Spiraea prunifolia var. simpliciflora

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