Esthesioneuroblastoma: The Northwestern University Experience

Argiris, Athanassios; Dutra, José; Tseke, Paraskevi; Haines, Kenneth

doi:10.1097/00005537-200301000-00029

Cited by 72 publications

(54 citation statements)

References 29 publications

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“…The main reported symptoms in our series were nasal block and headache; contrary to other papers, [11][12][13] epistaxis was infrequent. The differential diagnosis is made with other nasosinusal tumors, such as the inverted papilloma and squamous cell carcinomas.…”

Section: Discussioncontrasting

confidence: 97%

“…7,18 Preoperative CT and MRI are essential for surgical planning. [11][12] Minor complications such as cerebrospinal fluid leaks and intraorbitary hemorrhage have been described in this technique; the risk is similar to that of endoscopy in chronic sinusitis. 7 Several authors still defend en bloc craniofacial resection as the treatment of choice for tumors in general.…”

Section: Discussionmentioning

confidence: 97%

“…29 Neck metastases may be found in up to 5% of patients at the diagnosis. 12 These patients require neck dissection and/or radiotherapy. A review of the literature revealed that up to 23% of patients may have neck lesions as the disease progresses.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic treatment of esthesioneuroblastoma

Monteiro

Lopes

Santos

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Esthesioneuroblastoma is an uncommon malignant tumor of the nasal vault. Treatment consists of craniofacial resection. As endoscopic techniques have advanced, this approach has been recommended to avoid morbidity and to reduce costs. Aim To evaluate outcomes in patients with esthesioneuroblastoma treated by an endoscopic technique. Methods A prospective study of patients diagnosed with esthesioneuroblatoma and treated by an endoscopic technique. The literature over the past 20 years was reviewed for an update on the pathology. Results We present 4 patients, 3 males and 1 female, staged according to Kadish and Dulguerov. All were treated surgically with endoscopic techniques, followed by radiotherapy. One patient was also submitted to neck dissection and chemotherapy because of regional metastasis. There were no significant postoperative complications. The mean hospital stay was 3 days; one patient stayed in the ICU for 24 hours after surgery. Follow-up is recent; so far there are no recurrences. Conclusion Esthesioneuroblastoma is a potentially curable malignancy. Endoscopic techniques help reduce hospital costs and decrease the morbidity. Adequate margins of healthy tissue are obtained with endoscopic resection, as with craniofacial resection. The literature suggests that outcomes after endoscopic resection are similar to those of the conventional external approach.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Endoscopic treatment of esthesioneuroblastoma

Monteiro

Lopes

Santos

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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“…They occur at various ages, but have bimodal peaks in the second/third and sixth/seventh decades of life [5], and their rarity and highly heterogeneous nature have led to divergent opinions concerning their origin, growth, diagnosis, and management [1,2,6].…”

Section: Introductionmentioning

confidence: 99%

Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma

et al. 2005

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“…To improve the outcome, chemotherapy has been used in neoadjuvant and adjuvant treatments of locally advanced tumors; however, the survival data reflecting the outcome of chemotherapy are variable and chemotherapy's additional benefit, compared to just undergoing surgery or radiotherapy alone, remains uncertain [12,[33][34][35] . In a study reported by a group from the University of Virginia, patients with Kadish stage C received preoperative sequential chemotherapy (two cycles of vincristine + cyclophosphamide ± doxorubicin) and radiation therapy, followed by craniofacial resection.…”

Section: Discussionmentioning

confidence: 99%

Esthesioneuroblastoma: A case with prolonged disease control

et al. 2016

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Esthesioneuroblastoma, a rare tumor arising from the olfactory vault, varies from being indolent to extremely aggressive. Owing to its rarity, the diagnosis, staging, and treatment of the disease are not well defined. According to a number of small observational retrospective studies and case reports, the disease's actual treatment involves surgery, radiotherapy, and/or chemotherapy (either as a single treatment or used in combination), depending on the disease's staging. Optimal treatment has not been standardized, particularly regarding the role of chemotherapy. We describe a case of advanced esthesioneuroblastoma with prolonged disease control, subjected to a multimodal therapy with surgery, radiotherapy, and chemotherapy, illustrating the benefits of this approach in managing a patient with esthesioneuroblastoma. Herein, we analyze the most important and controversial issues of this type of neoplasia.Keywords: esthesioneuroblastoma; nasal cavity; surgery; radiotherapy; chemotherapy

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Esthesioneuroblastoma: The Northwestern University Experience

Abstract: Esthesioneuroblastoma is a rare tumor that is potentially curable by surgical resection and radiation therapy. However, the rate of local failure is high, and late recurrences are not uncommon. The role of chemotherapy warrants further investigation.

Cited by 72 publications

References 29 publications

Endoscopic treatment of esthesioneuroblastoma

Endoscopic treatment of esthesioneuroblastoma

Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma

Esthesioneuroblastoma: A case with prolonged disease control

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