Purpose: Quality of life (QOL) has been studied in various contexts and it presents complex components that compose a particular perception of the context where people live. This study evaluated the perception of QOL in Brazil and Portugal who participated in an online survey in both countries. Methodology: An online platform was built for data collection with socio-demographic information on physical activity. WHOQOL-bref from the World Health Organization (WHO) was the instrument used was to assess the perception of QOL. Results: The results show that the Portuguese have a higher QOL perception than the Brazilians do, especially in terms of physical and environment aspects, reflecting, in part, the socio-economic characteristics of these countries. Conclusions: This study emphasizes the importance of discussions on quality of life to consider models of a healthy life, quality of sleep and leisure.