Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Abstract

Purpose: To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas. Materials and Methods:This study describes a process for estimating both the gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas. The stability of the method was assessed. Estimates of CBV by this technique were compared to those of the conventional method. Results:The algorithm was found to be insensitive to noise and to generate stable voxel-by-voxel estimates of permeability and CBV. Conclusion:Using a single imaging acquisition, the three most important vascular properties, CBV, cerebral blood flow (CBF), and permeability, can be estimated. This approach may have potential in clinical evaluation of patients with brain tumor or acute ischemic stroke.

Multimodality Assessment of Brain Tumors and Tumor Recurrence

“…Cao et al proposed a special short T2*-weighted MRI sequence measuring perfusion parameters and permeability at the same time (86). Careful interpretation of data achieved by T1-or T2*-based MRI techniques is mandatory during therapy with corticosteroids or VEGF-specific antibodies (see the section on monitoring treatment effects with MRI).…”

Quantitative Estimation of Permeability Surface-Area Product in Astroglial Brain Tumors Using Perfusion CT and Correlation with Histopathologic Grade

“…9 Noninvasive measurement of vascular permeability has been done by using various MR perfusion techniques, which also have been correlated with glioma grading and treatment response. 6,7,[10][11][12][13] Perfusion CT (PCT) has been used for assessment of brain tumors [14][15][16][17] and has a number of advantages over MR imaging techniques, the most important of which may be the linearity of signal-intensity change to tissue concentration of contrast agent, which may not be the case with MR perfusion. [18][19][20][21] With PCT, multiple perfusion parameters such as permeability surface-area product (PS), cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) can be obtained with a single acquisition, which may be difficult with a single MR perfusion technique.…”

Contrast-Enhanced MR Imaging in Acute Ischemic Stroke: T2* Measures of Blood-Brain Barrier Permeability and Their Relationship to T1 Estimates and Hemorrhagic Transformation

“…This has encouraged some investigators to propose semiquantitative alternative measures that can be extracted from routine perfusion MR imaging data. [10][11][12][13][14][15][16] The strategy common to most, if not all, of the T2*-based metrics considered to date (eg, in gliomas 11,17 and, more recently, in AIS [14][15][16] ) has been to isolate the recirculation phase of the ⌬R 2 * versus time curve from the first-pass or intravascular phase. When BBB integrity becomes compromised, both the peak and recirculation phases of the associated ⌬R 2 * versus time curves are effectively blunted by contrast-agent extravasation and the attendant T1 shortening.…”