Estimated human absorbed dose for 68Ga-ECC based on mice data: comparison with 67Ga-ECC

Abstract

The results showed that (68)Ga-ECC is a more appropriate agent rather than (67)Ga-ECC and generally can be a good candidate for PET renal imaging applications.

Comparison of estimated human dose of 68Ga-MAA with 99mTc-MAA based on rat data

“…68 Ga results 4 gamma rays with 511 keV, but since the higher energies have lower cross section to the neighbor organs and therefore lower dose deliveries occur [6,10]. As represented in Table 1 and Fig.…”

“…3, the 99m Tc-MAA delivers higher doses compared to the 68 Ga-MAA. The lung and total body [6,39]. One of our limitations in this study is that we compare our estimated absorbed dose from 68 Ga-MAA with the real value data derived from ICRP 80 [33].…”

“…Previous studies stated that using mass extrapolation leads to some under and over estimations in dose calculations [6,10,[14][15][16]. Therefore, this under/over estimation should take into account for further studies.…”

“…These benefits of 68 Ga make it a very strong rival for 18 F, which is the most widely used PET radionuclide. 68 Ga as an excellent PET radionuclide has stimulated researchers to investigate the potential of 68 Ga-based PET imaging agents [5,6] insofar as a rough estimation demonstrates that the number of 68 Ga-related scientific articles published during 2011-2012 stands for over 45 % of all publications since 1956 [1].…”

Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

“…Uncertainties in the determinations were minimal, because each assay collected at least 10,000 counts, which results the standard deviation (SD) of\1 %. In all the measurements, we try to keep same geometry and same volume in order to prevent overestimation and underestimation in dose measurements [35]. All samples were background subtracted and decay correction was considered for all measurements, and the similar samples were averaged together [36,37].…”