Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model

Yang, Fan; Yang, Yurong; Wang, L.; Huang, Xianhui; Qiao, Guilin; Zeng, Zhenling

doi:10.1111/jvp.12137.

Cited by 28 publications

(50 citation statements)

References 32 publications

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“…The withdrawal time for marbofloxacin orally administered in broiler chickens was ranged between 3 days at a dose of 2mg/kg BW for 3 days [15] and Yang et al [21] reported 4 days at a dose of 5 mg/kg BW for 3 days that supported our results. The withdrawal period in rabbits was 2 days after S/C injection of marbofloxacin at a dose of 2mg/kg BW for 5 days as reported by Ligabue et al [17].…”

Section: Discussionsupporting

confidence: 88%

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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The present study was designed to evaluate marbofloxacin residues in different rabbit tissues after multiple intramuscular administrations. For that purpose, rabbits were divided into two groups; the first group (n=21) administered 2mg/kg marbofloxacin for five successive days, while the second group (n=3) were untreated and served as controls. th and 21 st day after the last dose post administration of the drug. Liver, kidneys, pectoral muscle and thigh muscles, spleen, heart, blood and lung from each rabbit were taken, extracted and marbofloxacin residues were analyzed using high-performance liquid chromatographic method with ultraviolet detection. Results indicated a widespread distribution of marbofloxacin in the most tested tissues. It remained within detectable level till the 5 th day in liver and serum while it continues till the 7 th in kidneys day following the last dose. Therefore, muscles of rabbits treated with marbofloxacin could be consumed safely following the 1 st day post treatment, while liver and kidneys could be consumed safely in the 3 rd day after treatment without any hazards on consumers as the residual level below the recommended MRL (150µg/kg).

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Section: Discussionsupporting

confidence: 88%

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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“…The marbofloxacin concentrations in plasma and tissues were measured by using a previously described method [20]. Briefly, 6 mL of trichloromethane was used to extract the marbofloxacin from 0.6 mL of plasma.…”

Section: Methodsmentioning

confidence: 99%

Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Yang

Liu

et al. 2017

J Vet Sci

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Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t1/2λz) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to ∞ (AUC0–∞s) were calculated to be 31.17 h·µg·mL−1 for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 h·µg·g−1 for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (Cmax) of marbofloxacin was 1.62 µg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 µg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.

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“…In recent years, there has been an increase in the applications of physiologically based pharmacokinetic (PBPK) models to predict veterinary drug residues (Huang et al., ; Li, Gehring, Riviere, & Lin, ; Yang, Huang, et al., ; Yang et al., ; Yang, Sun, Liu, & Zeng, ; Yang, Sun, et al., ; Yang et al., ; Zeng et al., ). Compared with the traditional monitoring method after animal slaughter, the PBPK model is based on mass‐balance equations defined by physiological mechanisms, and it is predictive in nature and allows for the use of in vitro mechanistic data and population variability data to predict the distribution of drug in animals (Lin, Gehring, Mochel, Lave, & Riviere, ).…”

Section: Introductionmentioning

confidence: 99%

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits

Yang

Shi

et al. 2018

Vet Pharm & Therapeutics

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To predict the orbifloxacin concentrations in rabbits after multiple routes of administration, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model was developed. Three routes of administration (IV, IM, and PO) were incorporated into this model. Physiological parameters including tissue weights and blood flows through different tissues were obtained from the literature. The tissue/plasma partition coefficients (P s) for noneliminating tissues were calculated according to the area method, while the P s for kidney and the rest of the body compartment, together with other parameters for absorption and elimination, were optimized based on the published concentrations. The comparisons between predicted and observed orbifloxacin concentrations proved its validity, and the present model predicted available concentration data well, including those in liver, kidney, muscle, lung, heart, and plasma after oral, intravenous, or intramuscular administration. A local sensitivity analysis was also performed, which showed that the parameters for oral absorption were most influential on the orbifloxacin concentrations. This model was used to predict plasma and tissue concentrations after multiple oral or intramuscular administration. This study demonstrated the feasibility of predicting drug residues in minor species after multiple routes of administration in the extra-label manner using the PBPK modeling.

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Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model

Cited by 28 publications

References 32 publications

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits

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