A Cyber-Physical Model of Internet of Humans (CPMIOH) is proposed in this paper. With the great advance of semiconductor technology, many wearable sensors are available nowadays. The low cost, proper accuracy, low energy consumption, and portable features of these kind sensors make a wearable device popular in recent years. Most of the applications of wearable devices are implemented in the areas of medical evaluation, clinical diagnosis, healthcare, game and entertainment, and personal fitness. However, the application in the industry is still limited. A CPMIOH is composed of wearable devices equipping on the body of workers in the factory, wireless data collecting devices, cloud data storage servers, network communication protocols, and algorithms for human movement measurement and recognition. Under this architecture, the human motion analysis is not limited in the laboratory but realized in the practical work environment. In this CPMIOH model, workers could be evaluated through continuous analysis of movement measurement and classification. The operations of a task might be reviewed repeatedly by the representation of 3D human motion model in the computer. This model also provides a potential objective analysis to complement traditional subjective evaluation methods in the ergonomic risk evaluation on the work-related musculoskeletal disorders. The biofeedback sensors also provide long-term data while the workers are exposed to the real work environment. This data assists the analysis of objective mental load in a real time. The work stress evaluation of a job would not be limited by the post subjective methods. This application would not only do benefit to monitor the stress of workers exposed to the high tension work environment but also provide an opportunity to improve the psychological health of workers by job redesign.